Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00445055
Details
2011-12-13
Interventional
471 
Droperidol
Nausea Postoperative N… Vomiting
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NCT00554775
2006-000113-38
Details
2011-12-12
Interventional
280 
Erlotinib Hydro…
Brain Neoplasms Lung Neoplasms Lung Cancer Metastatic Canc…
IDMC made a recommendation to stop the trial as the target for continuing to the 2nd phase was not met.
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NCT00565656
Details
2011-12-08
Interventional
2-
Bevacizumab
Myelodysplastic… Preleukemia Syndrome
-
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NCT00456482
Details
2011-12-08
Interventional
2/3239 
Fluocinolone Ac…
Uveitis Non-infectious …
SARS epidemic in Asia and Canada
-
NCT00460551
Details
2011-12-06
Interventional
213 
Zalutumumab
Carcinoma, Non-… Lung Neoplasms Non Small Cell …
Due to considerations regarding the appropriate therapeutic regimen for these patients.
The trial was prematurely closed. The original protocol contained Part 1A, followed by Part 1B and Part 2. The trial was terminated when 13 patients were enrolled in Part 1A. Scans for efficacy were planned for Part 1B and Part 2.
NCT01029795
Details
2011-12-02
Interventional
238 
Glyburide
Diabetes Mellit… Diabetes Mellit…
Terminated due to nonclinical safety findings
Since Study GMAJ was terminated after enrolling only 38 participants with just 1 participant completing 12 weeks of treatment, only disposition, demographics, and safety data are reported.
NCT00593008
Details
2011-12-02
Interventional
15 
Gemcitabine MTOR Inhibitors Sirolimus Temsirolimus
Pancreatic Neop… Pancreatic Aden…
-
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NCT01204853
Details
2011-12-01
Interventional
32 
Sitaxsentan
Hypertension Hypertension, P… Pulmonary Arter…
Safety Issue: The trial was prematurely terminated on Dec 9, 2010, due to safety concerns, specifically new emerging evidence of hepatic injury.
-
NCT00418574
2006-002801-30
Details
2011-11-24
Interventional
2/3888 
Abagovomab
Carcinoma, Ovar… Ovarian Neoplas… Ovarian Cancer
No benefit on primary end point (RFS); no rationale to collect survival data
-
NCT00400764
Details
2011-11-23
Interventional
1/272 
Rituximab
Lymphoma Lymphoma, Non-H… Non-Hodgkin's L…
-
The Sponsor terminated the study on 5 May 2010, prior to the completion of the 36-month follow-up (FU) period, based on the primary analysis results. All patients were off-study or in survival FU (the treatment period was completed).
NCT01473069
Details
2011-11-21
Interventional
141 
Ketoconazole
Healthy
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-
NCT01014481
Details
2011-11-17
Interventional
4156 
Efavirenz Lamivudine Tenofovir
Tuberculosis HIV Infections
this study was ended prematurely by ethical committees with a reason of the final outcome was achieved with no longer recruitment was needed.
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NCT01165970
2008-005451-23
2008-005451-23
Details
2011-11-15
Interventional
2/319 
Carboxymethylce…
Xerostomia Hyposalivation
-
-
NCT00169221
Details
2011-11-15
Interventional
254 
Gefitinib
Head and Neck N… Head and Neck C…
Toxicity in an independent study IMEX. The trial was subsequently terminated (54 pts instead of 140) despite safety analyses showing no excess of toxicity
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NCT01029223
Details
2011-11-09
Interventional
4-
Metoprolol
Blood Pressure
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NCT00957346
Details
2011-11-08
Interventional
3-
Mifepristone Misoprostol
Abortion, Induc…
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NCT00171600
Details
2011-11-08
Interventional
454 
Lisinopril Valsartan
Diabetic Nephro… Kidney Diseases Early Diabetic … Hypertension
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NCT00111306
2005-000705-59
Details
2011-11-08
Interventional
3-
Epratuzumab
Lupus Erythemat… Systemic Lupus …
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NCT00083993
Details
2011-11-08
Interventional
3-
Letrozole MTOR Inhibitors Sirolimus Temsirolimus
Breast Neoplasm… Neoplasm Metast… Neoplasms
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NCT00918931
Details
2011-11-04
Interventional
23 
Obatoclax
Mastocytosis Mastocytosis, S… Leukemia Systemic Mastoc…
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