Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00296062
Details
2012-01-16
Interventional
112 
Bevacizumab Capecitabine Irinotecan Oxaliplatin
Colorectal Neop… Colorectal Canc… Unspecified Adu…
Trial did not move to Phase II portion due to poor tolerance of treatment
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NCT00245128
Details
2012-01-13
Interventional
210 
Imatinib Mesyla…
Myeloproliferat… Primary Myelofi… Chronic Myelopr…
Per PI, results from another similar study were published prior to study analysis. Negative study results were published therefore analysis was not completed
Early termination/results were never analyzed due to negative study results from other similar studies.
NCT01416870
Details
2012-01-11
Interventional
1102 
Bicalutamide
Healthy
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NCT01252342
Details
2012-01-11
Interventional
40 
Oxytocin
Hemorrhage Postpartum Hemo… Uterine Inertia Uterine Atony
Proposed doses were too large, bolus oxytocin may cause cases of arrythmias, and some even advocate slowing down the infusion rates that are currently used.
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NCT00492388
Details
2012-01-11
Interventional
32 
Ketamine
Breakthrough Pa… Cancer Pain
Business decision not to continue development
-
NCT00969293
Details
2012-01-10
Interventional
111 
Ecallantide
Edema Macular Edema Retinal Vein Oc… Central Retinal…
-
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NCT01233947
Details
2012-01-09
Interventional
27 
Fulvestrant
Breast Neoplasm… Breast Neoplasm
-
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NCT00159575
2004-001124-20
Details
2012-01-05
Interventional
4
[1 Refs]
150 
Metformin
Polycystic Ovar… Syndrome
Slow patient recruitment and expiry of study medication(aug2009)
-
NCT01169870
Details
2012-01-04
Interventional
20 
Paclitaxel genexol-PM
Breast Neoplasm… Breast Cancer
withdrawn studies
-
NCT01412515
Details
2012-01-02
Interventional
211 
Everolimus
Sarcoma Sarcoma, Kaposi Kaposi Sarcoma
results from interim analysis conducted to study interruption
-
NCT00504491
2007-003097-26
Details
2011-12-30
Interventional
20 
Alemtuzumab Rituximab
Leukemia Leukemia, Lymph… Leukemia, Lymph… Chronic Lymphoc… Patients Relaps… Patients Resist…
IMP new owner decision
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NCT01080768
2009-014359-63
Details
2011-12-26
Interventional
231 
Aliskiren Amlodipine
Hypertension Ankle Edema
Publication of data from a similar study made the current study redundant.
-
NCT00401401
Details
2011-12-23
Interventional
1/230 
Zalutumumab
Carcinoma, Squa… Head and Neck N… Neoplasms, Squa… Head and Neck C… Squamous Cell C…
MTD was established and patients completed 16 months safety f-up and response assessments. It is considered of limited value to follow patients for 3 years.
All adverse events were collected during the 8 week treatment period and for additional 4 weeks. Serious adverse events were collected for the extended follow-up period of up to 3 years. The planned parallell group of the study was cancelled.
NCT01106235
Details
2011-12-21
Interventional
1-
Aldesleukin Cyclophosphamid… Interleukin-2
Melanoma Stage IV Melano…
-
-
NCT00946907
Details
2011-12-21
Interventional
434 
Aspirin
Pericarditis
This study was suspended by principal investigator's decision. All the sites were not opened, and the recruitment was so slow.
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NCT01441388
Details
2011-12-20
Interventional
10 
Axitinib Bevacizumab Crizotinib Sorafenib Sunitinib
Carcinoma Carcinoma, Hepa… Carcinoma, Rena… Glioblastoma
Business/Operational issues
-
NCT00238355
Details
2011-12-19
Interventional
213 
Caspofungin Voriconazole
Communicable Di… Infections Invasive Fungal… Mycoses Infection Unspecified Adu…
competing study at site
-
NCT00217152
Details
2011-12-19
Interventional
412 
Mycophenolic Ac…
Delayed Graft F… Kidney Transpla…
Roche decided to prematurely terminate study.
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NCT01210443
Details
2011-12-14
Interventional
32 
Sitaxsentan
Hypertension Hypertension, P… Pulmonary Arter…
Safety Issue: The trial was prematurely terminated on Dec 9, 2010, due to safety concerns, specifically new emerging evidence of hepatic injury.
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NCT00802048
Details
2011-12-13
Interventional
321 
Anesthetics Anesthetics, Lo… Ropivacaine
Hyperalgesia Pain
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