Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01353482
2009-013638-26
Details
2012-03-22
Interventional
1/20 
Pemetrexed Vorinostat
Mesothelioma Mesothelioma, M… Malignant Pleur…
UCL CTC were informed by Merck Sharp & Dohme on 22.08.11 that support for the trial had been withdrawn in light of results from another trial with trial drug.
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NCT01044225
2009-012324-83
Details
2012-03-22
Interventional
212 
Cetuximab
Glioblastoma
Results of the phase III RTOG0525 trial made the manufacturer of cilengitide decide to end their support to the trial
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NCT00586365
Details
2012-03-21
Interventional
40 
Naproxen
Ossification, H… Heterotopic Oss…
Too difficult to satisfy all the inclusion criteria.
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NCT01517308
Details
2012-03-19
Interventional
30 
Interferon alph… Interferon-alph… Interferons Peginterferon a… Ribavirin
Hepatitis Hepatitis A Hepatitis C Hepatitis C, Ch… Hepatitis, Chro… Chronic Hepatit…
Time elapsed to require permissions and a recent paper showed a high efficacy of a 48-week regimen in this setting. It seems non-ethical to start this trial
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NCT00799760
2008-004026-16
Details
2012-03-19
Interventional
3
[1 Refs]
541 
Oseltamivir Zanamivir
Influenza, Huma… Gastric Influen…
Just Terminated for the end of the pandemia
-
NCT00281125
Details
2012-03-19
Interventional
1/2-
Pemetrexed Vatalanib
Carcinoma, Non-… Lung Neoplasms Mesothelioma Mesothelioma, M… Non-Small Cell …
Suspended due to data issues revealed at DSMB meeting. Planned amendment but was never submitted. Study was then closed.
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NCT00532038
Details
2012-03-16
Interventional
3179 
Ketoprofen
Osteoarthritis Osteoarthritis,…
Corporate decision
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NCT00528827
Details
2012-03-16
Interventional
20 
Nicardipine
Hypertension
Due to the sale of Cardene IV, the sponsor has stopped enrollment and withdrawn the study. No safety issues were identified.
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NCT01162889
Details
2012-03-15
Interventional
170 
Antibodies, Mon…
Healthy
See termination reason in detailed description.
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NCT01436032
Details
2012-03-14
Interventional
350 
Ketorolac Ketorolac Trome…
Laparoscopic Su…
-
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NCT01066468
2010-018418-53
Details
2012-03-13
Interventional
13 
Imatinib Mesyla…
Hematologic Dis… Leukemia Leukemia, Lymph… Leukemia, Myelo… Leukemia, Myelo… Philadelphia Ch… Precursor Cell … Chronic Myeloid… Other Glivec/Gl… Philadelphia Ch…
-
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NCT00518284
Details
2012-03-13
Interventional
26 
Albumin-Bound P… Paclitaxel
Peripheral Arte… Peripheral Vasc… Vascular Diseas… Vascular Diseas…
Study was terminated due to changing sponsor priorities, and was not based on safety or outcomes data.
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NCT00279435
Details
2012-03-12
Interventional
2/325 
Visilizumab
Colitis Colitis, Ulcera… Ulcer Ulcerative Coli…
company decision based on other studies
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NCT00279422
Details
2012-03-12
Interventional
2/3127 
Visilizumab
Colitis Colitis, Ulcera… Ulcer Ulcerative Coli…
DMC recommendation, no efficacy
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NCT01545427
Details
2012-03-07
Interventional
210 
Imatinib Mesyla…
Scleroderma, Di… Scleroderma, Lo… Scleroderma, Sy… Scleroderma
Frequent adverse events occurred early in treatment with poor tolerability.
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NCT01409408
Details
2012-03-06
Interventional
40 
Aliskiren Amlodipine
Diabetes Mellit… Hypertension
Due to preliminary results of Altitude Trial.
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NCT00998101
Details
2012-03-06
Interventional
20 
Carboplatin Cetuximab
Carcinoma, Non-… Lung Neoplasms Lung Cancer
Study was withdrawn due issuses related to the science
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NCT00881673
Details
2012-03-06
Interventional
20 
Dexamethasone Ophthalmic Solu…
Conjunctivitis Conjunctivitis,… Allergic Conjun…
Management decision
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NCT00741845
Details
2012-03-06
Interventional
3117 
Metronidazole
Vaginal Disease… Vaginosis, Bact… Bacterial Vagin…
Terminated for site documentation and monitoring issues - not safety, study drug, or adverse event issues.
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NCT00572182
NCT00923208
Details
2012-03-06
Interventional
133 
3-(4-((4-chloro…
Central Nervous… Nervous System … Brain and Centr…
This Phase I study was permanently closed to patient accrual on February 23, 2011, due to the discontinuation of support from MERCK.
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