Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00811018
Details
2012-04-24
Interventional
31192 
Sitaxsentan
Familial Primar… Hypertension Pulmonary Arter…
This trial was prematurely terminated on Dec 9 2010 due to safety concerns, specifically emerging evidence of hepatic injury.
Mean and dispersion for clinical abnormalities were intended to be reported but due to early termination of study (09-Dec-2010) only number and percent of participants are available.
NCT01296698
Details
2012-04-23
Interventional
3257 
Nicotine
Tobacco Use Dis… Tobacco Depende…
Study terminated due to a technical issue (randomization error).
Summary tabulations are not available for the primary and some secondary outcome measures because the study was terminated early due to a technical issue (randomization error).
NCT00499889
Details
2012-04-23
Interventional
242 
Antilymphocyte … Busulfan Fludarabine Fludarabine pho… Imatinib Mesyla… Methotrexate Tacrolimus Thymoglobulin Vidarabine
Leukemia
Support issue.
Study completed early due to support issues.
NCT00337740
Details
2012-04-23
Interventional
3-
Propranolol
Esophageal and … Liver Cirrhosis Esophageal Vari…
From the interim analysis resulted that more than 1000 patients were required to demonstrate a significant difference between the 2 treatments.
-
NCT00771706
Details
2012-04-20
Interventional
30 
Proton Pump Inh…
Chronic Cough Cough Esophagitis, Pe… Gastroesophagea…
This study was not activated, no data was collected.
-
NCT00414024
Details
2012-04-20
Interventional
311 
Tegaserod
Constipation Opioid-Induced … Opioid-induced …
This study was terminated early as a result of regulatory action suspending tegaserod use in 2007
-
NCT00365820
Details
2012-04-20
Interventional
2/3-
Tegaserod
Constipation Opioid-Induced …
This study was terminated early as a result of regulatory action suspending tegaserod use in 2007
-
NCT00241046
Details
2012-04-19
Interventional
413 
Letrozole
Breast Neoplasm… Metastatic Brea…
-
-
NCT01082718
Details
2012-04-13
Interventional
2/30 
Artesunate Mefloquine
Malaria Pregnancy
Logistical difficulties
-
NCT00248131
Details
2012-04-10
Interventional
3-
Octreotide
Diabetic Retino… Retinal Disease…
-
-
NCT00113971
Details
2012-04-03
Interventional
2-
Epratuzumab
Lupus Erythemat…
-
-
NCT00437359
Details
2012-03-30
Interventional
2-
Anastrozole Toremifene
Breast Neoplasm…
-
-
NCT00138229
NCT00118599
Details
2012-03-29
Interventional
26 
Aldesleukin Cyclophosphamid… Fludarabine Fludarabine pho…
Melanoma Melanoma (Skin)
-
-
NCT01102218
Details
2012-03-28
Interventional
248 
Epoetin Alfa Pentoxifylline
Anemia Kidney Diseases Kidney Failure,… End Stage Renal…
Lack of statistical difference between both arms of the trial.
Release of new FDA guidelines re target Hgb values impacted EPO dosing.
NCT00854230
Details
2012-03-28
Interventional
40 
Naltrexone
Acquired Immuno… Alcohol-Related… Communicable Di… HIV Infections Infections HIV Infection Heavy Alcoholic…
We expanded to a bigger, multi-site study & decided to close this study.
-
NCT00820924
Details
2012-03-28
Interventional
223 
Lapatinib
Breast Neoplasm… Neoplastic Cell… Neoplasms, Brea…
-
-
NCT00495625
Details
2012-03-27
Interventional
233 
Sunitinib
Carcinoma, Hepa… Liver Neoplasms Liver Cancer
-
The Principal Investigator who initiated the study left Moffitt before reaching the target enrollment required to perform the planned analysis.
NCT01445587
Details
2012-03-26
Interventional
20 
Bortezomib
Multiple Myelom… Neoplasms, Plas… Cancer
Based on the clinical activity, not safety data, of the AKT inhibitor, GSK has decided at this time to suspend further development of GSK2110183 as monotherapy.
-
NCT01367990
Details
2012-03-23
Interventional
13 
Norepinephrine
Alopecia Alopecia Areata Head and Neck N… Radiodermatitis
Study site has terminated the study due to the complexity of the study
-
NCT00827099
Details
2012-03-23
Interventional
25 
Antilymphocyte … Fludarabine Fludarabine pho… Melphalan Mycophenolic Ac… Tacrolimus
Leukemia Lymphoma Multiple Myelom… Myelodysplastic… Myeloproliferat… Neoplasms, Plas… Plasmacytoma Preleukemia Syndrome Multiple Myelom…
Unacceptable morbidity & mortality
This study was terminated early, therefore no additional data measures or outcomes are available.