Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00151736
Details
2012-06-11
Interventional
288 
Chlorambucil Etodolac
Leukemia Leukemia, Lymph… Leukemia, Lymph… Chronic Lymphoc…
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NCT00910299
Details
2012-06-08
Interventional
2423 
Clopidogrel Prasugrel Hydro…
Coronary Artery… Coronary Artery…
Due to the low rate of primary endpoint events experienced in the study to date
The study was terminated early, and no formal statistical time-to-event analysis was performed.
NCT00638833
Details
2012-06-08
Interventional
220 
Memantine
Multiple Sclero… Sclerosis
Unexpected side-effects: reversible and mild to moderate neurological impairment
-
NCT01070745
Details
2012-06-07
Interventional
20 
Ibuprofen Indomethacin
Ductus Arterios… Patent Ductus A…
Changes in approach to PDA therapy
-
NCT00618384
Details
2012-06-07
Interventional
243 
Sorafenib
Carcinoma Carcinoma, Hepa… Hepatocellular …
-
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NCT00383214
2005-000706-31
Details
2012-06-07
Interventional
354 
Epratuzumab
Lupus Erythemat… Systemic Lupus …
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NCT00148252
Details
2012-06-07
Interventional
4-
Mycophenolic Ac…
Renal Transplan…
To high rejection rate in CsA withdrawal arm
-
NCT00050297
Details
2012-06-07
Interventional
2-
N-(6-methoxy-5-…
Prostatic Neopl… Prostate Cancer
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-
NCT00048659
Details
2012-06-07
Interventional
2-
N-(6-methoxy-5-…
Prostatic Neopl… Hormone-Refract…
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-
NCT00586794
Details
2012-06-06
Interventional
324 
Sildenafil Citr…
Eisenmenger Com… Familial Primar… Hypertension Pulmonary Arter… Pulmonary Arter…
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-
NCT00564993
2007-003461-41
Details
2012-06-06
Interventional
353 
Dobutamine
Tetralogy of Fa…
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-
NCT00536003
Details
2012-06-06
Interventional
3384 
Progesterone
Obstetric Labor… Perinatal Death Premature Birth Morbidity Perinatal Morta… Preterm Deliver…
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NCT00005608
Details
2012-06-06
Interventional
2-
Calcium Leucovorin Levoleucovorin Tegafur
Breast Neoplasm… Breast Cancer
Drug was pulled from the market.
-
NCT00224679
Details
2012-06-05
Interventional
3-
Aspirin
Adenoma Recurrence Colon Adenomas
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-
NCT00126789
Details
2012-06-05
Interventional
324 
Fentanyl
Cancer Pain Cancer Pain
Based on PK data, product did not meet requirement for further development.
-
NCT00126763
Details
2012-06-05
Interventional
3105 
Fentanyl
Chronic Pain Pain
PK results suggested product did not meet requirement for further development.
-
NCT00437164
Details
2012-06-04
Interventional
21 
Insulin Insulin, Globin…
Diabetes Mellit… Diabetes Mellit… Type 2 Diabetes…
Company decision not related to safety.
-
NCT00403182
2005-000986-20
Details
2012-06-01
Interventional
30 
Letrozole
Breast Neoplasm… Breast Cancer
study halted prematurely, prior to enrollment of first participant
-
NCT01491139
2010-023599-24
Details
2012-05-30
Interventional
10 
Olaparib
Carcinoma Carcinoma, Squa… Squamous Cell C…
Study stopped due to issues surrounding development and formulation of olaparib
-
NCT00705770
Details
2012-05-30
Interventional
2/30 
Anecortave Hydrocortisone
Glaucoma Glaucoma, Open-… Open-Angle Glau…
Change in study design
-