Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03115151
Details
2023-10-26
Interventional
446 
Bupivacaine Fentanyl Hydromorphone
Pain
The surgical team has difficulty to find level 1 and 2 fusions for the study.
-
NCT01307956
Details
2023-10-26
Interventional
211 
Antibodies Antibodies, Mon… Antineoplastic … Calcium Calcium, Dietar… Fluorouracil Folic Acid Immunoglobulins Leucovorin Levoleucovorin Oxaliplatin Panitumumab
Adenocarcinoma Esophageal Neop… Adenocarcinoma … Esophageal Aden… Stage IIA Esoph… Stage IIB Esoph…
Drug manufacturer - Amgen requested study stop, per DSMB observation in POWER trial
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NCT01280669
Details
2023-10-26
Interventional
20 
Sirolimus
Panuveitis Pars Planitis Uveitis Uveitis, Interm… Uveitis, Poster… Intermediate Uv… Posterior Uveit…
Never started due to sponsor decision
-
NCT06017323
Details
2023-10-25
Interventional
10 
Gemcitabine Paclitaxel Proglumide
Pancreatic Neop… Metastatic Panc…
STUDY00006987
-
NCT05255484
Details
2023-10-25
Interventional
1/224 
Antibodies
Neoplasms Advanced Solid …
Completed primary objective.
-
NCT04890353
Details
2023-10-25
Interventional
1/22 
Dimethyl Fumara…
Cerebral Infarc… Ischemia Ischemic Stroke Stroke Acute Ischemic …
The interim analysis of another associated study is not very effective
-
NCT02833701
Details
2023-10-24
Interventional
19 
Antibodies Antibodies, Mon… Antineoplastic … Ascorbic Acid Bevacizumab Endothelial Gro… Immunoglobulin … Immunoglobulins Vitamins
Glioblastoma Glioma
-
-
NCT02254031
Details
2023-10-24
Interventional
18 
Bivatuzumab mer… Maytansine
Breast Neoplasm…
-
-
NCT00170950
NCT00097864
Details
2023-10-24
Interventional
3
[1 Refs]
11506 
Amlodipine Benazepril Hydrochlorothia…
Hypertension
The study was terminated early because of significant efficacy results for the primary endpoint in favor of benazepril/amlodipine treatment.
Study was stopped early, as recommended by the Data Monitoring Committee, due to positive efficacy results.
NCT05138822
Details
2023-10-23
Interventional
1-
Nitrofurantoin
Communicable Di… Infections Urinary Tract I… Uncomplicated U…
To allow analysis of data from supplementary non-clinical study.
-
NCT04699461
2020-003695-40
Details
2023-10-23
Interventional
26 
Idelalisib Loncastuximab t…
Lymphoma Lymphoma, Folli… Refractory Foll… Relapsed Follic…
Administrative decision (not due to safety reason)
The study was terminated (administrative decision) by the sponsor following the withdrawal of idelalisib from the US market for the relapsed FL indication (i.e., not due to any safety reasons emerging from this study).
NCT04485052
Details
2023-10-23
Interventional
1/2-
Azacitidine Decitabine
Leukemia Leukemia, Myelo… Leukemia, Myelo… Acute Myeloid L…
Pause for changes in development strategies
-
NCT04343235
Details
2023-10-23
Interventional
413 
Furosemide Labetalol
Hypertension Hypertension, P…
Challenges with enrollment; primary investigator left the institution
-
NCT04308785
Details
2023-10-23
Interventional
224 
Atezolizumab
Carcinoma, Smal… Small Cell Lung… Carcinoma, Smal…
The sponsor's decision was based on the negative results of SKYSCRAPER-02.
-
NCT03292731
Details
2023-10-23
Interventional
1/2159 
11-hydroxyproge… 17 alpha-Hydrox…
Premature Birth Preterm Birth
grant funding cycle ended
Statistical analysis limited due to inadequate enrollment and subsequent small sample size and few cases of sPTB.
NCT00476515
Details
2023-10-23
Interventional
10 
Rituximab
Renal Insuffici… Kidney Insuffic…
Protocol to be revised
-
NCT06090318
Details
2023-10-19
Interventional
1/20 
Atezolizumab
Carcinoma Carcinoma, Rena… Mesothelioma Urinary Bladder… Advanced Solid … CDKN2A Gastric Cancer HNSCC Melanoma NSCLC Pancreas Adenoc… Renal Cell Carc… Urothelial Carc…
Sponsor Decision
-
NCT04666623
Details
2023-10-19
Interventional
20 
Esketamine
Cancer Pain Pain, Intractab…
investigator decision
-
NCT04648189
Details
2023-10-19
Interventional
20 
Cetuximab
Lung Neoplasms Neoplastic Cell… Circulating Tum… Lung Cancer Surgery
One of the participating specialties has decided to no longer cooperate in this research
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NCT03672643
Details
2023-10-19
Interventional
441 
Crizotinib
Carcinoma, Non-… ALK or ROS1-pos…
The trial is terminated based on business decision, not due to safety concerns or regulatory requirements.
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