Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00334763
Details
2012-07-10
Interventional
2-
Bevacizumab Carboplatin Paclitaxel
Carcinoma, Non-… Lung Neoplasms Lung Cancer
Principal Investigator felt risk to patients was too high.
-
NCT00950027
2006-006353-27
Details
2012-07-06
Interventional
3179 
Povidone Povidone-Iodine
Cerebral Hemorr… Craniocerebral … Hemorrhage Pneumonia Pneumonia, Vent… Ventilator Asso…
-
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NCT00876317
Details
2012-07-03
Interventional
345 
Etoricoxib
Bursitis Rheumatic Disea… Soft Tissue Inj… Tenosynovitis Soft Tissue Inj… Tenosynovitis a…
Change in current areas of research interest of the collaborator
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NCT01015495
Details
2012-07-02
Interventional
1/20 
Ranibizumab
Angioid Streaks Choroidal Neova… Neovascularizat…
Not enough patients within the time frame to allow for a meaningful study.
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NCT01226901
Details
2012-06-28
Interventional
13 
Niraparib
Neoplasms Solid Tumors
-
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NCT00477230
Details
2012-06-27
Interventional
364 
Anti-Arrhythmia…
Atrial Fibrilla…
Study terminated based on decision of Sponsor.
This study was terminated early due to Sponsor decision. Therefore, full patient assignement to treatments post-randomziation did not occur. Results and other measures cannot be determined because most patients exited the study before completion.
NCT00971191
Details
2012-06-22
Interventional
122 
Dacomitinib
Carcinoma, Non-… Lung Neoplasms Non-Small Cell …
See termination reason in detailed description.
-
NCT00305383
Details
2012-06-22
Interventional
2-
Peginterferon a… Taribavirin
Hepatitis Hepatitis A Hepatitis C Hepatitis C, Ch…
Dose levels were determined to be subtherapeutic
-
NCT00798525
2006-003122-28
Details
2012-06-21
Interventional
470 
Argatroban Lepirudin
Critical Illnes… Thrombocytopeni… Heparin Induced…
Supply of Lepirudin ended on 01. April 2012, thus trial terminated on 31. March 2012
-
NCT01373593
Details
2012-06-20
Interventional
412 
Lidocaine
Pain
-
-
NCT00886496
Details
2012-06-20
Interventional
10 
Lectins
Fever Hot Flashes Leukemia Lymphoma Myelodysplastic… Neutropenia Preleukemia Syndrome Fever, Sweats, … Infection Unspecified Chi…
No participants enrolled. IND withdrawn.
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NCT00331890
Details
2012-06-20
Interventional
3
[1 Refs]
2298 
Choline Cytidine Diphos…
Cerebral Infarc… Infarction Stroke Acute Stroke
With 2078 patients, a statistical stopping boundary has now been crossed
-
NCT00528255
Details
2012-06-18
Interventional
20 
Misoprostol
Cervical Ripeni… Induction of La…
PK portion will be included in a future protocol
-
NCT00630383
Details
2012-06-14
Interventional
20 
Histamine
Multiple Sclero… Sclerosis
superceded by another similar study
-
NCT00333424
NCT00476749
NCT00859248
NCT00859820
Details
2012-06-13
Interventional
1/2
[1 Refs]
8 
Vaccines
HIV
Vaccines safe but not immunogenic in 8 participants; trial closed to further recruitment by the protocol steering committee & DSMB.
-
NCT00845598
Details
2012-06-12
Interventional
40 
Azelastine Fluticasone Xhance
Rhinitis Rhinitis, Aller… Allergic Rhinit…
Could not get IMP
-
NCT00447226
Details
2012-06-12
Interventional
232 
Lapatinib
Cancer
The study had failed to meet the primary objective of tumor response rate at 12 weeks from first dose.
Study terminated prematurely: preliminary assessment (prompted by low screening/enrollment rates) showed primary objective of tumor response rate not met. Also unable to test primary treatment comparison after randomization following SD at 12 wks.
NCT00004897
Details
2012-06-12
Interventional
2-
Calcium Fluorouracil Hydroxyurea Interferon-alph… Interferons Leucovorin Levoleucovorin
Esophageal Neop… Esophageal Canc…
Institutional Review Board requested termination - all patients deceased and no new accrual.
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NCT01273064
Details
2012-06-11
Interventional
2114 
Interferons Ribavirin
Hepatitis Hepatitis A Hepatitis C
Risk-benefit ratio
This study was terminated early after 3 reports of hyperbilirubinemia occurred(2 on 60mg bid and 1 on 30mg bid of CTS 1027). Two incidents were reported as part of an SAE. The risk/benefit ratio did not warrant further continuation of the study.
NCT00389519
Details
2012-06-11
Interventional
3422 
Ramipril
Hypertension
A planned interim analysis was performed after approx. 240 subjects completed the trial. The study was stopped, as permitted by protocol, after the analysis.
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