Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

Filter:

Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
Free Text
Annotations

7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00513305
Details
2012-08-01
Interventional
367 
Arsenic Trioxid… Cytarabine
Leukemia Leukemia, Myelo… Leukemia, Myelo… Acute Myeloid L…
Study has been stopped by sponsor decision
In September 2009, the sponsor decided to stop the study due to difficulty in enrollment. The study was stopped prior to the first planned interim analysis. Most of the analysis planned in the protocol was not performed.
NCT00426829
Details
2012-08-01
Interventional
13 
Bevacizumab
Carcinoma, Hepa… Cholangiocarcin… Liver Neoplasms Hepatocellular … Liver Cancer
Low Accural
-
NCT00062023
Details
2012-07-30
Interventional
212 
Aspirin Sulindac Ursodeoxycholic…
Colorectal Neop… Colorectal Canc…
Study closed by the NCI.
-
NCT00733967
Details
2012-07-27
Interventional
10 
Varenicline
Substance-Relat… Methamphetamine… Methamphetamine… Substance Abuse
No longer active
-
NCT01005290
Details
2012-07-26
Interventional
238 
Ramipril
Hypertension
-
Early termination leading to small numbers of subjects analyzed
NCT00127881
Details
2012-07-26
Interventional
376 
Zanolimumab
Mycoses Mycosis Fungoid… Sezary Syndrome Syndrome
New sponsor, other treatments available
-
NCT01648595
Details
2012-07-24
Interventional
2/3-
Fentanyl
Labor Pain Decrease Labor …
-
-
NCT00803868
Details
2012-07-24
Interventional
2/328 
Varenicline
Ataxia Cerebellar Atax… Friedreich Atax… Friedreich's At…
The DSMB recommended that the study be stopped as a result of concerns regarding safety and intolerability and insufficient evidence of efficacy.
-
NCT00682500
Details
2012-07-24
Interventional
3332 
Calfactant
Acute Lung Inju… Respiratory Dis… Respiratory Dis… Syndrome Respiratory Dis…
Expected mortality rates in placebo and treatment groups lower than predicted
-
NCT01646580
2008-003560-19
Details
2012-07-20
Interventional
421 
Ciclopirox
Dermatomycoses
Low recruitment rate. with the final sample primary endpoint could be assessed.
-
NCT01645774
Details
2012-07-20
Interventional
2/390 
Oxymetazoline
Contusions Bruising Pain
-
-
NCT00767481
2008-002781-66
Details
2012-07-19
Interventional
36 
Brinzolamide Travoprost
Glaucoma Hypertension Ocular Hyperten…
Project Cancelled
-
NCT00783250
Details
2012-07-17
Interventional
420 
Albuterol Tiotropium Brom…
Lung Diseases Lung Diseases, … Pulmonary Disea… Chronic Obstruc…
Problems with data collection
-
NCT00600639
Details
2012-07-17
Interventional
482 
Albuterol Anti-Bacterial … Antibiotics, An… Methylprednisol… Methylprednisol… Methylprednisol… Prednisolone Prednisolone ac… Prednisolone he… Prednisolone ph…
Respiratory Ins… Acute Respirato…
-
-
NCT01248234
Details
2012-07-16
Interventional
30 
Etomidate Propofol
Hypertension
Did not begin
-
NCT00430937
Details
2012-07-16
Interventional
3194 
Daptomycin Teicoplanin Vancomycin
Communicable Di… Infections Skin Diseases Skin Diseases, … Soft Tissue Inf…
-
-
NCT01005641
2008-007946-67
Details
2012-07-13
Interventional
20 
Exemestane Lapatinib
Breast Neoplasm… Breast Cancer
Study not started for administrative reasons
-
NCT01637571
Details
2012-07-11
Interventional
40 
Dexlansoprazole Lansoprazole
Chest Pain Esophagitis, Pe… Gastroesophagea… Gastrointestina…
Sponsor could not fund
-
NCT00665678
Details
2012-07-11
Interventional
4-
Paroxetine
Stress Disorder… Stress Disorder… Posttraumatic S…
-
-
NCT00343096
Details
2012-07-10
Interventional
3800 
Lorazepam
Seizures Status Epilepti… Convulsions
The buccal arm of the study was 30% less effective in stopping seizures within 10 minutes compared with the IV dose. This met a stopping rule for the study
-