Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01005095
Details
2012-09-05
Interventional
445 
Cholecalciferol Ergocalciferols Vitamin D Vitamins
Multiple Sclero… Multiple Sclero… Sclerosis MULTIPLE SCLERO…
Interim analysis showed that the odds for proving primary hypothesis are low.
-
NCT01125917
Details
2012-09-03
Interventional
3354 
Buprenorphine
Back Pain Low Back Pain Back Pain Lower…
Terminated early due to administrative reasons.
BUP3015S was terminated early due to administrative reasons unrelated to efficacy or safety. There was full evaluation of safety but no evaluation of efficacy.
NCT00452361
Details
2012-09-03
Interventional
431 
Calcineurin Inh… Cyclosporine Cyclosporins Sirolimus Tacrolimus
Kidney Transpla…
-
Study terminated early due to difficulties in enrolling qualified patients. No patients completed 104 weeks (primary outcome); a few completed 60 weeks. Insufficient data were available for efficacy analyses.
NCT00320801
NCT01137422
Details
2012-09-03
Interventional
3188 
Buprenorphine
Osteoarthritis
This study was terminated early due to administrative reasons.
Study terminated due to administrative reasons. The primary objective was changed to a safety study prior to unblinding.
NCT00315458
NCT01137279
Details
2012-09-03
Interventional
3107 
Buprenorphine
Osteoarthritis
Administrative reasons.
This study was terminated early for administrative reasons. The efficacy data are not presented since the primary objective of this study was changed identifying it as a safety study.
NCT00313014
Details
2012-09-03
Interventional
3
[1 Refs]
660 
Buprenorphine Oxycodone
Back Pain Low Back Pain Back Pain Lower…
Terminated early due to administrative reasons unrelated to efficacy or safety.
BUP3015 was terminated early due to administrative reasons unrelated to efficacy or safety.
NCT01575899
Details
2012-08-31
Interventional
4208 
Amoxicillin Amoxicillin-Pot… Clarithromycin Clavulanic Acid Levofloxacin Ofloxacin Rabeprazole
Helicobacter Py…
Early termination due to efficacy
The limitation of this study is the local primary resistance of Hp to levofloxacin and to amoxicillin/clavulanate is unknown. We are currently engaged in an on-going investigation of the influence of CYP2C19 genotypes on this new regimen.
NCT01044394
Details
2012-08-31
Interventional
20 
Bisacodyl
Bowel Preparati…
A phase III RCT was published showing this approach is effective
-
NCT01004705
Details
2012-08-31
Interventional
236 
Aspirin Ramipril Simvastatin
Elevated LDL Ch…
-
Early termination leading to small numbers of subjects analyzed.
NCT00948389
2009-010576-21
Details
2012-08-31
Interventional
1/228 
Dasatinib Lomustine
Glioblastoma
Inability to meet protocol objectives
-
NCT01131585
2010-018852-29
Details
2012-08-30
Interventional
3128 
Ranibizumab
Edema Macular Edema Vision Disorder… Vision, Low Visual Impairme…
European drug approval.
Early study termination due to European drug approval.
NCT00793650
Details
2012-08-30
Interventional
1/239 
Bortezomib Melphalan
Multiple Myelom… Neoplasms, Plas… Cancer
-
-
NCT00612521
Details
2012-08-29
Interventional
3200 
Adenosine
Coronary Artery… Coronary Diseas… Coronary Stenos… Myocardial Isch… Coronary Artery…
At half the sample size, the results were negative with no benefit demonstrated with adenosine.
-
NCT01125449
Details
2012-08-28
Interventional
2-
Ascorbic Acid
Desmoplastic Sm… Multiple Myelom… Adenocarcinoma Carcinoma Sarcoma
Awaiting response from FDA as to status of parenteral ascorbic acid manufactured by Bioniche (Ireland).
-
NCT01036399
2007-003911-29
Details
2012-08-27
Interventional
29 
Lenalidomide
Lymphoma Lymphoma, T-Cel… Lymphoma, T-Cel… Peripheral T-ce…
The EC withdrawn the approval becuase of possible conflicts of interests between our Institute and Supporter (Celgene)
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NCT00983151
Details
2012-08-27
Interventional
3-
Tramadol
Premature Birth Premature Ejacu…
-
-
NCT00968331
Details
2012-08-27
Interventional
225 
Lenalidomide Rituximab
Lymphoma Lymphoma, B-Cel… Lymphoma, Large… Diffuse Large B…
The EC withdrawn the approval becuase of possible conflicts of interests between our Institute and Supporter (Celgene)
-
NCT01088256
2009-015496-27
Details
2012-08-24
Interventional
29 
Etoricoxib
Causalgia Hyperalgesia Neuralgia Neuralgia, Post… Peripheral Nerv… Polyneuropathie… Radiculopathy Peripheral Nerv… Polyneuropathy Postherpetic Ne…
-
-
NCT00936780
Details
2012-08-23
Interventional
467 
Paclitaxel
Coronary Artery… Coronary Diseas… Myocardial Isch…
market demand from paclitaxel to sirolimus drug-eluting stent
-
NCT00917163
Details
2012-08-23
Interventional
413 
Everolimus Sirolimus
Coronary Artery… Coronary Diseas… Myocardial Isch…
due to unavoidable circumstances relating to logistic issues and regulatory processes in various countries causing unacceptable delays.
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