Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00005067
Details
2013-01-16
Interventional
124 
Motexafin lutet…
Prostatic Neopl… Recurrence Adenocarcinoma … Recurrent Prost… Stage I Prostat… Stage IIA Prost… Stage IIB Prost…
Administratively complete.
-
NCT00101088
Details
2013-01-14
Interventional
121 
Imatinib Mesyla… MTOR Inhibitors Sirolimus Temsirolimus
Blast Crisis Leukemia Leukemia, Myelo… Leukemia, Myelo… Leukemia, Myelo… Leukemia, Myelo… Accelerated Pha… Blastic Phase C… Chronic Myeloge… Chronic Phase C… Relapsing Chron…
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NCT00003613
Details
2013-01-11
Interventional
1-
Carmustine O(6)-benzylguan…
Lymphoma Lymphoma, Non-H… Lymphoma, T-Cel… Lymphoma, T-Cel… Recurrent Cutan… Stage I Cutaneo… Stage II Cutane…
-
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NCT00862134
NCT00840021
Details
2013-01-10
Interventional
242 
Docetaxel Lenograstim
Carcinoma, Non-… Lung Neoplasms Non-Small Cell …
Interim analysis indicated low probability of clinically significant result
-
NCT00766337
Details
2013-01-10
Interventional
262 
MTOR Inhibitors Ranibizumab Sirolimus Temsirolimus
Choroidal Neova… Macular Degener… Neovascularizat… Age-Related Mac…
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NCT00712491
Details
2013-01-10
Interventional
1/220 
MTOR Inhibitors Sirolimus Temsirolimus
Choroidal Neova… Macular Degener… Neovascularizat… Age-related Mac…
-
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NCT00086983
Details
2013-01-10
Interventional
1-
Oxaliplatin
Neoplasms Unspecified Adu…
-
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NCT01611506
Details
2013-01-09
Interventional
1/21 
Capecitabine Cetuximab
Stomach Neoplas… Gastric Cancer
Outcome of EXPAND study (no benefit from adding cetuximab to the first-line chemotherapy in advanced gastric cancer in the overall patient population)
-
NCT00512668
Details
2013-01-07
Interventional
124 
Bicalutamide Flutamide Goserelin Leuprolide MTOR Inhibitors Nilutamide Sirolimus Temsirolimus
Prostatic Neopl… Adenocarcinoma … Recurrent Prost…
-
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NCT00301795
Details
2013-01-07
Interventional
2-
Oblimersen Rituximab
Lymphoma Lymphoma, Folli… Lymphoma, Non-H… Stage III Grade… Stage III Grade… Stage III Grade… Stage IV Grade … Stage IV Grade … Stage IV Grade …
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NCT00089089
Details
2013-01-07
Interventional
142 
Azacitidine Decitabine
Hematopoietic/L… Unspecified Adu…
-
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NCT00087256
Details
2013-01-07
Interventional
318 
Celecoxib
Colonic Neoplas… Colorectal Canc…
For scientific, logistic, and administrative reasons.
-
NCT00080847
Details
2013-01-07
Interventional
2160 
Cyclophosphamid… Doxorubicin Liposomal doxor… Oblimersen Prednisone Rituximab Vincristine
Lymphoma Lymphoma, Large… Lymphoma, Non-H… Contiguous Stag… Noncontiguous S… Stage III Adult… Stage IV Adult …
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NCT00894023
Details
2013-01-04
Interventional
3150 
Abciximab
Infarction Myocardial Infa… Acute Myocardia…
the study was stopped because the sample size was very difficult to achieve.
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NCT00561197
Details
2013-01-04
Interventional
1/213 
Gossypol acetic…
Locally Advance…
Drug not being developed for this indication
-
NCT00837759
Details
2013-01-03
Interventional
27 
Dexlansoprazole Lansoprazole Sitagliptin Pho…
Diabetes Mellit… Diabetes Mellit… Autoimmune Diab… Diabetes Mellit…
Changes to study personnel.
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NCT00902525
Details
2012-12-31
Interventional
225 
Antibodies, Mon…
Lymphoma Lymphoma, B-Cel… Lymphoma, Large… Diffuse Large B…
After enrolling 25 patients an interim analysis was done.The study was discontinued in the absence of the minimum number of 6 patients free of events
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NCT00617058
Details
2012-12-31
Interventional
21 
Metformin
Weight Gain
Terminated in lieu of similar,competing large, multi-site study.
In terms of study limitations, this research study was only able to enroll a single study participant before the trial was terminated prematurely due to study start-up for a larger, multisite effort examining similar outcome measures.
NCT00589693
2007-004646-33
Details
2012-12-28
Interventional
3274 
Cilastatin Cilastatin, Imi… Doripenem Imipenem
Pneumonia Pneumonia, Vent… Ventilator-Asso…
Observed lower cure rates and higher mortality rates in one of the treatment groups.
41 patients (21 doripenem, 20 imipenem-cilastatin) were enrolled at 5 sites that were found to be Good Clinical Practice non-compliant and were excluded from the primary efficacy and safety analyses.
NCT01312064
Details
2012-12-27
Interventional
42 
Everolimus Rituximab Tacrolimus Thymoglobulin
Renal Insuffici…
Difficulty collecting
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