Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT04056741
Details
2023-11-01
Interventional
2-
Pulmonary Surfa…
Lung Diseases Chronic Lung Di… RDS of Prematur… Surfactant Prot…
alteration of study required
-
NCT02403323
2014-003855-76
Details
2023-11-01
Interventional
3-
Etrolizumab
Crohn Disease
The study was terminated due to program discontinuation, based on mixed efficacy results in the parent studies. There were no safety concerns.
-
NCT02118584
2013-004435-72
Details
2023-11-01
Interventional
31822 
Etrolizumab
Colitis Colitis, Ulcera… Ulcer Ulcerative Coli…
The study was terminated due to program discontinuation, based on mixed efficacy results in the parent studies. There were no safety concerns.
-
NCT04770155
Details
2023-10-31
Interventional
18 
Bosentan Sildenafil Citr…
Racial Disparit… Vascular Functi…
Despite significant effort, we were unable to obtain the supply of drugs and supplements needed for the various arms of this Clinical Trial.
The only data collected were baseline measurements and no participants were ever given either intervention; the investigator was never able to obtain the treatments to use for the planned intervention arm of the study, resulting in its termination.
NCT04751955
Details
2023-10-31
Interventional
1/20 
Capecitabine
Colorectal Neop… Colorectal Canc…
This clinical trial was not finally approved by the Korea FDA.
-
NCT04601324
Details
2023-10-31
Interventional
40 
Azelastine Fluticasone Xhance
Rhinitis Rhinitis, Aller… Allergic Rhinit…
PI did not pursue this study
-
NCT05525455
Details
2023-10-30
Interventional
1/29 
Immune Checkpoi…
Neoplasms Advanced Cancer Advanced Solid … Cancer Oncology
Company operational decision. Decision to stop study is not due to safety or efficacy concerns.
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NCT05151471
Details
2023-10-30
Interventional
3202 
Edaravone
ALS
Futility Analysis of parent study MT-1186-A02 was met.
-
NCT04983407
Details
2023-10-30
Interventional
1/234 
Gemcitabine Paclitaxel
Adenocarcinoma Pancreatic Aden…
Due to business reasons
-
NCT04300140
Details
2023-10-30
Interventional
1/272 
Nivolumab
Carcinoma Carcinoma, Rena… Clear Cell Rena…
Due to business reasons
-
NCT04212650
Details
2023-10-30
Interventional
1/21 
Losartan
Fibrosis Osteoarthritis,… Cartilage Damag… Hip Impingement… Hip Osteoarthri…
redesigned trial using another placebo controlled drug
Per opinion of the Principal Investigator, Losartan is now clinically indicated as a standard of care post-operative therapy for patients undergoing hip microfracture surgeries. The study was terminated early, resulting in a singular subject enrolled for data analysis. The subject elected to withdraw from the study prior to the first follow-up data collection timepoint.
NCT03992196
Details
2023-10-30
Interventional
310 
Rotigotine
Psychomotor Agi… Restless Legs S… Syndrome
Sponsor decision; Not a safety decision
-
NCT03970200
Details
2023-10-30
Interventional
215 
Anti-Bacterial …
Clostridium Inf… Communicable Di… Infections Severe Clostrid… Severe-Complica…
Administrative reasons.
-
NCT02470585
2014-005070-11
Details
2023-10-30
Interventional
31140 
Carboplatin Paclitaxel Veliparib
Ovarian Neoplas… Ovarian Cancer Ovarian Neoplas…
Business decision not related to patient safety
-
NCT01545141
Details
2023-10-27
Interventional
1/215 
Celecoxib Interferon alph… Interferon-alfa… Interferon-alph… Interferons Poly I-C poly(I).poly(c1…
Colorectal Neop… Colorectal Canc… Colorectal Carc… Colorectal Tumo… Neoplasms, Colo…
-
-
NCT05329545
Details
2023-10-26
Interventional
320 
Immunoconjugate…
Carcinoma, Ovar… Fallopian Tube … Hypersensitivit… Ovarian Neoplas… Fallopian Tube … High Grade Sero… Primary Periton…
Study Terminated by Sponsor
-
NCT04320940
Details
2023-10-26
Interventional
34 
Phenobarbital
Epilepsy, Benig… Seizures
Insufficient participant recruitment hindered the study's progress, preventing robust data collection and compromising statistical power
-
NCT04245722
Details
2023-10-26
Interventional
198 
Bendamustine Hy… Cyclophosphamid… Fludarabine Obinutuzumab Rituximab
Leukemia Leukemia, Lymph… Leukemia, Lymph… Lymphoma Lymphoma, B-Cel… Chronic Lymphoc…
The study was terminated by the Sponsor.
-
NCT04023071
Details
2023-10-26
Interventional
172 
Bendamustine Hy… Cyclophosphamid… Fludarabine Obinutuzumab Rituximab
Leukemia Leukemia, Myelo… Leukemia, Myelo… Lymphoma Lymphoma, B-Cel… Acute Myelogeno… B-cell Lymphoma
The study was terminated by the Sponsor.
-
NCT03728933
Details
2023-10-26
Interventional
323 
Rotigotine
Psychomotor Agi… Restless Legs S… Syndrome
Sponsor decision; Not a safety decision
-