Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01261702
Details
2013-02-18
Interventional
432 
Magnesium Sulfa…
Magnesium Sulph… Pain Post Pulmonary …
not include patient anymore
-
NCT01463215
Details
2013-02-15
Interventional
1/2-
Ambroxol
Gaucher Disease Type I Gaucher …
-
-
NCT01510977
Details
2013-02-13
Interventional
4150 
Bisacodyl
Colonoscopy Fai… Poor Bowel Prep…
-
-
NCT01481610
Details
2013-02-13
Interventional
228 
Diclofenac Lumiracoxib
Arthralgia Kidney Failure,… Renal Insuffici…
Interim analysis shows harma to one of the study arms.
-
NCT01067326
Details
2013-02-13
Interventional
322 
Aliskiren
Atherosclerosis Endothelial Dys…
Novartis ended all studies regarding Aliskiren.
The study was terminated early due to safety concerns from the ALTITUDE trial; there was an unexpected increase in adverse events (non-fatal stroke, renal complications, hyperkalemia and hypotension). Novartis ended all studies regarding Aliskiren.
NCT01198873
Details
2013-02-12
Interventional
476 
Dronedarone
Atrial Fibrilla…
-
Due to the early termination of the study, results should be cautiously interpreted. Indeed the number of participants was lower than planned (76 instead of 334) and the treatment period was shorter than planned (6 months instead of 12 months).
NCT00447265
Details
2013-02-12
Interventional
21 
Etanercept
Lupus Nephritis Nephritis
The perceived risk-benefit ratio for individuals with early active RA
The study terminated early with 1 subject enrolled. Based on safety info from other trials, the protocol chairs decided possible risks to patients outweighed the potential benefits. Analysis of groups is not possible. Study objectives cannot be met.
NCT00396812
Details
2013-02-12
Interventional
1/24 
Rituximab
Arthritis Arthritis, Rheu… Rheumatoid Arth…
The perceived risk-benefit ratio for individuals with early active RA
The trial terminated early due to rituximab's risk-benefit ratio for individuals with early active Rheumatoid Arthritis. Mechanistic samples were not processed and corresponding endpoints were not assessed. Only descriptive statistics are presented.
NCT00366704
Details
2013-02-11
Interventional
3-
Risperidone
Schizophrenia
-
-
NCT00724685
2007-002983-89
Details
2013-02-08
Interventional
434 
Ropivacaine
Post Operative …
-
-
NCT00137345
Details
2013-02-08
Interventional
3-
Sirolimus
Kidney Transpla…
-
-
NCT01269411
Details
2013-02-07
Interventional
122 
2,2-dimethyl-N-…
Brain Neoplasms Glioblastoma Glioma Gliosarcoma Oligodendroglio… Recurrence Adult Anaplasti… Adult Brain Ste… Adult Giant Cel… Adult Glioblast… Adult Gliosarco… Adult Mixed Gli… Recurrent Adult…
Administratively complete.
-
NCT00177138
Details
2013-02-07
Interventional
49 
Alemtuzumab Tacrolimus
Diabetes Mellit…
The clinical use of Campath for transplant patients was temporarily suspended.
-
NCT00005808
Details
2013-02-07
Interventional
154 
Motexafin lutet…
Carcinoma in Si… Neoplasms Uterine Cervica… Cervical Cancer Cervical Intrae… Cervical Intrae…
Administratively complete.
-
NCT00066625
Details
2013-02-01
Interventional
130 
Bortezomib Oxaliplatin
Unspecified Adu…
Administratively complete.
-
NCT00042835
Details
2013-02-01
Interventional
148 
Carboplatin Docetaxel Erlotinib Hydro… Etoposide Etoposide phosp… Paclitaxel
Adenocarcinoma … Adenocarcinoma,… Carcinoma, Non-… Lung Neoplasms Adenocarcinoma … Bronchoalveolar… Large Cell Lung… Squamous Cell L… Stage IIIA Non-… Stage IIIB Non-…
Administratively complete.
-
NCT00039455
Details
2013-02-01
Interventional
150 
Alvocidib Trastuzumab
Breast Neoplasm… Breast Neoplasm… HER2-positive B… Male Breast Can… Recurrent Breas… Stage IV Breast…
Administratively complete.
-
NCT00002796
NCT01925326
Details
2013-02-01
Interventional
1/246 
4-phenylbutyric… Fluorouracil Indomethacin Interferon-gamm… Interferons
Adenocarcinoma Adenocarcinoma,… Colonic Neoplas… Cystadenocarcin… Rectal Neoplasm… Recurrence Mucinous Adenoc… Mucinous Adenoc… Recurrent Colon… Recurrent Recta… Signet Ring Ade… Signet Ring Ade… Stage IVA Colon… Stage IVA Recta… Stage IVB Colon… Stage IVB Recta…
Administratively complete.
-
NCT01301313
2009-017827-24
Details
2013-01-31
Interventional
2116 
Simendan
Heart Failure Acute Heart Fai…
-
-
NCT00840489
Details
2013-01-31
Interventional
250 
Colchicine Ribavirin
Hepatitis Hepatitis A Hepatitis C Hepatitis C, Ch… Hepatitis, Chro… Chronic Hepatit…
Preliminary analysis
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