Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00060996
Details
2013-03-07
Interventional
3-
Treprostinil
Chronic Limb-Th… Foot Ulcer Ischemia Peripheral Arte… Peripheral Vasc… Vascular Diseas… Critical Limb I… Foot Ulcers Peripheral Vasc… Rest Leg Pain
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NCT01279291
Details
2013-03-06
Interventional
122 
Carboplatin Doxorubicin Gemcitabine Liposomal doxor… Paclitaxel
Carcinoma, Ovar… Fallopian Tube … Neoplasms Ovarian Neoplas… Peritoneal Neop… Primary Periton…
The study was stopped due to the inability to determine an acceptable dose with the potential for further study
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NCT01111682
Details
2013-03-05
Interventional
35 
Mannitol
Brain Injuries Brain Injuries,… Intracranial Hy… Elevated Intrac… Traumatic Brain…
A significant reduction in head injuries coupled with more frequent use of crainectomy reduced the number of potential subjects.
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NCT00950820
Details
2013-03-04
Interventional
29 
Capecitabine Oxaliplatin Panitumumab
Colorectal Neop…
Recruitment rate to low; changed environment made protocol in its current state obsolete
-
NCT00889343
Details
2013-03-04
Interventional
2101 
Fluorouracil Irinotecan Leucovorin Oxaliplatin Sorafenib
Colorectal Neop…
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NCT00870441
Details
2013-02-28
Interventional
1442 
Valacyclovir
Safety of ASP21…
Study terminated due to treatment-emergent serious adverse events
-
NCT00820612
Details
2013-02-28
Interventional
4602 
Indomethacin
Pancreatitis Post-ERCP Pancr…
Stopped by DSMB for overwhelming benefit of indomethacin (unethical to withhold indomethacin from patients)
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NCT01658358
Details
2013-02-27
Interventional
1/2-
Doxorubicin Lapatinib Liposomal doxor…
Breast Neoplasm… Metastatic Brea…
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-
NCT01016054
Details
2013-02-27
Interventional
14 
Carboplatin Doxorubicin Gemcitabine Liposomal doxor…
Carcinoma, Ovar… Ovarian Disease… Ovarian Neoplas… Carcinoma Ovarian Cancer
Trial was terminated to allow sponsors to evaluate the future development of the drug program
-
NCT01798602
Details
2013-02-26
Interventional
28 
Rosuvastatin Ca…
H1N1 Influenza
H1N1 pandemic concluded
-
NCT01223755
2007-005047-21
Details
2013-02-25
Interventional
2/341 
Sirolimus
Arthrogryposis Kidney Diseases Polycystic Kidn… Polycystic Kidn… Renal Insuffici… Autosomal Domin…
safety and efficacy reason
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NCT00696787
Details
2013-02-25
Interventional
2125 
Desvenlafaxine … Pregabalin
Fibromyalgia Myofascial Pain…
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-
NCT01058408
Details
2013-02-22
Interventional
13 
Cisplatin Everolimus
Head and Neck N… Head and Neck C…
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NCT00959946
Details
2013-02-22
Interventional
1/232 
Bosutinib Capecitabine
Breast Neoplasm… Cholangiocarcin… Glioblastoma Advanced Breast… Advanced Cholan… Advanced Colore… Advanced Gliobl… Advanced Pancre…
-
Results are not provided because the study was terminated prior to part 2 due to unfavorable risk benefit ratio of the study treatment.
NCT00744250
Details
2013-02-22
Interventional
43 
Pancreatin Pancrelipase
Cystic Fibrosis Exocrine Pancre… Fibrosis Pancreatitis Pancreatitis, C… Chronic Pancrea…
No longer required study by FDA for NDA approval.
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NCT01142128
Details
2013-02-21
Interventional
112 
Esomeprazole Pancreatin Pancrelipase
Pancreatitis Pancreatitis, C… Chronic Pancrea…
Viokase was taken off market during study and remained off over a year.
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NCT01033955
Details
2013-02-21
Interventional
28 
Rosuvastatin Ca…
Critical Illnes… Infections Influenza, Huma… Critically Ill H1N1/Influenza …
H1N1 pandemic concluded in early 2010
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NCT01680796
Details
2013-02-20
Interventional
10 
Bortezomib Dexamethasone
Multiple Myelom… Neoplasms, Plas…
The target drug, dovitinib, failed as a single agent in prior studies in patients with heavily treated multiple myeloma.
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NCT00531115
2006-007062-11
Details
2013-02-20
Interventional
228 
Cetuximab
Colorectal Neop… Metastatic Colo…
According to the study design, in the first step the number of responses was lower than the number required (< 7).
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NCT00433953
Details
2013-02-20
Interventional
144 
Mycophenolic Ac…
Kidney Transpla…
No longer following patient and no plans to publish.
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