Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT05263505
Details
2023-11-07
Interventional
22 
Azathioprine Methotrexate
Conjunctivitis Pemphigoid, Ben… Pemphigoid, Bul… Cicatrizing Con… Mucous Membrane…
Sponsor
-
NCT05111314
Details
2023-11-07
Interventional
10 
Edetic Acid Gallium 68 PSMA…
Carcinoma Carcinoma, Hepa… Hepatocellular …
PI requested
-
NCT04917055
Details
2023-11-07
Interventional
414 
Dexamethasone Epinephrine Ropivacaine
Acute Pain Anesthesia, Loc… Knee Osteoarthr… Regional Anesth…
staffing
-
NCT04631601
2020-001305-23
Details
2023-11-07
Interventional
1/265 
Androgen Recept… Androgens Immune Checkpoi…
Prostatic Neopl… Metastatic Cast…
Amgen made a business decision to discontinue all AMG 160 clinical trials. This decision is not related to safety.
-
NCT03555149
2017-004566-99
Details
2023-11-07
Interventional
1/296 
Atezolizumab Bevacizumab
Colorectal Neop… Colorectal Canc…
The Sponsor made the decision to terminate the study due to start up and recruitment issues caused by limited resource availability at the treating centers.
This study is not designed to make explicit power and Type I error considerations for a hypothesis test. Instead, this study is designed to obtain preliminary efficacy, safety, and PK data. No formal statistical hypothesis testing was performed in this study. Due to the limited sample size, the results need to be interpreted with caution. For the Atezo+Idasa and Atezo+LOAd703 groups, no meaningful conclusion could be drawn because these experimental arms have been terminated prematurely.
NCT02170025
2013-004595-35
Details
2023-11-07
Interventional
2
[1 Refs]
21 
Riociguat
Cystic Fibrosis Fibrosis
Study was terminated after completion of Part 1, because Part 2 was no longer appropriate.
Based on multiple factors, the design of part 2 is no longer appropriate. Study was terminated at the end of part 1. No safety concerns were identified.
NCT01133990
2009-016015-37
Details
2023-11-07
Interventional
1/25 
Bevacizumab Calcium Fluorouracil Irinotecan Leucovorin Levoleucovorin
Colorectal Neop… Colorectal Canc…
The study was terminated early as the combination of E7820 and FOLFIRI was deemed to be not tolerable, hence no efficacy analysis was conducted.
The study was terminated early as the combination of E7820 and FOLFIRI was deemed to be not tolerable, hence no efficacy analysis was conducted.
NCT00668772
2007-005107-17
Details
2023-11-07
Interventional
3207 
Salmeterol Xina… Tiotropium Brom…
Pulmonary Disea…
-
-
NCT05712941
Details
2023-11-03
Interventional
30 
Letrozole
Carcinoma Endometrial Neo… Endometrial Car…
The study is being closed based on corporate changes at EQRx and is not related to any efficacy or safety issues with lerociclib.
-
NCT05405439
Details
2023-11-03
Interventional
1/239 
Abiraterone Ace… Prednisone
Prostatic Neopl… Metastatic Cast…
The sponsor voluntarily terminated the study
-
NCT04885634
2021-002017-34
Details
2023-11-03
Interventional
30 
Semaglutide
Atrial Fibrilla… Overweight Overweight and …
Not received funding.
-
NCT04397458
Details
2023-11-03
Interventional
40 
Bupivacaine Dexamethasone
Analgesics Analgesics, Opi… Morphine Peripheral Nerv…
COVID-19 pandemic and competing study that took precedence
-
NCT03605342
Details
2023-11-03
Interventional
237 
Buprenorphine
Stress Disorder… Stress Disorder… Opiate Use Diso… Post-Traumatic …
Early termination
-
NCT00625586
Details
2023-11-03
Interventional
22 
Gemcitabine
Pancreatic Neop… Pancreatic Canc…
Corporate decision
-
NCT05705492
Details
2023-11-02
Interventional
2-
Olanzapine
Advanced Malign…
Pending protocol revisions
-
NCT05288283
Details
2023-11-02
Interventional
33 
Cannabidiol
Epilepsy Seizures Seizures Associ…
The study was terminated due to a business decision.
-
NCT02616185
Details
2023-11-02
Interventional
191 
Tremelimumab
Prostatic Neopl…
Due to strategic evaluation of PF-06753512 (VBIR-1) within context of Pfizer's oncology portfolio, decision not based on any safety or regulatory concerns.
The study was terminated on 20 August 2020 by the sponsor. The decision to terminate this study was based on the results of a strategic evaluation of VBIR-1 within the current Pfizer oncology portfolio. This decision was not based on any safety or regulatory concerns with the treatment of participants with VBIR-1.
NCT00687453
Details
2023-11-02
Interventional
427 
Insulin Glargin…
Diabetes Mellit… Type 2 Diabetes…
-
Early termination leading to smaller than anticipated enrollment.
NCT05546411
Details
2023-11-01
Interventional
28 
Camptothecin Fluorouracil Irinotecan Leucovorin Levoleucovorin Oxaliplatin
Adenocarcinoma Pancreatic Neop… Borderline Rese… Pancreatic Aden… Pancreatic Canc… Resectable Panc…
Novartis, the drug manufacturer of NIS793, notified Dana Farber Cancer Institute that they are stopping all clinical development of NIS793 in pancreatic cancer, effective immediately.
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NCT05170828
NCT05068401
Details
2023-11-01
Interventional
10 
Busulfan Cyclophosphamid… Fludarabine Mycophenolic Ac… Sirolimus
Hematologic Neo… Leukemia Leukemia, Biphe… Myelodysplastic… Precursor Cell … Acute Biphenoty… Acute Leukemia Acute Lymphocyt… Acute Myeloid L… Acute Undiffere… T-lymphoblastic…
Change in Study Design
-