Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01400308
Details
2013-08-02
Interventional
499 
Mupirocin
Staphylococcal … MRSA - Methicil… MRSA Colonizati…
The differences seen between treatments led to recalculation of the sample, unattainable in a reasonable time
-
NCT01105390
Details
2013-08-02
Interventional
20 
Antibodies, Mon… Pemetrexed Rilotumumab
Lung Neoplasms Mesothelioma Mesothelioma, M… Advanced Malign… Epithelial Meso… Recurrent Malig… Sarcomatous Mes…
withdrawn
-
NCT00089115
Details
2013-08-02
Interventional
3
[1 Refs]
-
Antibodies Immunoglobulin … Immunoglobulins Immunoglobulins… Rituximab Sargramostim
Lymphoma Lymphoma, Non-H…
Withdrawn as company has shut down and filed for bankruptcy
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NCT00002696
Details
2013-08-02
Interventional
3-
Cyclophosphamid… Doxorubicin Fluorouracil Liposomal doxor… Methotrexate
Breast Neoplasm… Breast Cancer
-
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NCT00805740
Details
2013-08-01
Interventional
341 
Anidulafungin Caspofungin
Candidiasis Fungemia Infections
The study was terminated prematurely on May 18, 2012 due to slow enrollment. The study was not terminated due to any safety issues or concerns.
The study was prematurely terminated due to slow enrollment. The study was not terminated due to any safety issues or concerns.
NCT01369121
Details
2013-07-30
Interventional
1/215 
Corticotropin-R…
Brain Edema Brain Neoplasms Brain Tumor
Single subject remained on study - transferred to compassionate use
-
NCT00589953
Details
2013-07-30
Interventional
222 
Epoetin Alfa
Brain Injuries Hemorrhage Leukomalacia, P… Premature Birth Wounds and Inju… Brain Injury Erythropoietin Infant, Prematu… Intraventricula… Neurodevelopmen… Periventricular… Randomized Clin…
-
-
NCT01910532
Details
2013-07-29
Interventional
40 
Clevidipine
Hypertension
Sponsor discontinued the research
-
NCT01728181
Details
2013-07-25
Interventional
1/20 
Erlotinib Hydro… Tivozanib
Carcinoma, Non-… Lung Neoplasms EGFR Unknown or… Non-small Cell … Stage IV Diseas…
Stopped before approval due to ineffective drug
-
NCT00564655
Details
2013-07-24
Interventional
33 
Bupivacaine Epinephrine Epinephryl bora… Racepinephrine
Anesthesia Enteral Nutriti…
-
-
NCT00872976
Details
2013-07-22
Interventional
10 
Bendamustine Hy… Dasatinib
Leukemia Leukemia, Lymph… Leukemia, Lymph… Chronic Lymphoc…
Business Objectives Changed
-
NCT00866008
Details
2013-07-22
Interventional
434 
Ganirelix Triptorelin Pam…
Aneuploidy In Vitro Fertil…
Due to a very slow inclusion rate.
-
NCT00386152
Details
2013-07-19
Interventional
2235 
Darbepoetin alf… Epoetin Alfa
Anemia Cancer Neoplasms
No safety signals were noted. The study was stopped because it was no longer consistent with the company's scientific and strategic focus.
Due to the significantly reduced power (stopped prematurely when 235 patients enrolled), all protocol-specified hypothesis tests were not performed. Instead, desriptive statistics were presented for each of the endpoints by treatment group.
NCT01284166
Details
2013-07-18
Interventional
30 
Brimonidine Tar… Dorzolamide Ophthalmic Solu… Timolol
Glaucoma Hypertension Ocular Hyperten…
Study was never initiated due to company decision. No study subjects were ever enrolled or treated.
-
NCT00557830
Details
2013-07-18
Interventional
212 
Sorafenib
Carcinoma Carcinoma, Rena… Renal Cell Carc…
The study was closed to enrollment when it became clear that enrollment was too slow to complete the full enrollment target within the time frame allowed.
The decision to close the study was made by the funder , Bayer HealthCare Pharmaceuticals, in collaboration with ACORN due to the low rate of accrual in light of study timelines and the lack of funds beyond the current level of support from Bayer.
NCT01583062
Details
2013-07-15
Interventional
4217 
Amoxicillin Clavulanic Acid Clavulanic Acid…
Fractures, Bone Mandibular Frac… Surgical Wound Surgical Wound … Wound Infection
Limited number of patients
-
NCT01262612
Details
2013-07-15
Interventional
212 
Cediranib
Ascites Pleural Effusio… Pleural Effusio… Malignant Ascit… Malignant Pleur…
-
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NCT00931021
Details
2013-07-15
Interventional
17 
Nicotine Varenicline
Head and Neck N… Smoking Cessati…
-
-
NCT00635505
Details
2013-07-15
Interventional
3300 
Albuterol
Asthma
IND voluntarily withdrawn, without prejudice
-
NCT00634829
Details
2013-07-15
Interventional
324 
Albuterol
Bronchial Spasm Asthma Bronchospasm
IND voluntarily withdrawn, without prejudice
-