Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00818961
Details
2013-12-18
Interventional
236 
Alemtuzumab Busulfan Cyclophosphamid… Fludarabine Fludarabine pho… Methotrexate Rituximab Tacrolimus
Leukemia Lymphoma Myelodysplastic… Myelodysplastic… Myeloproliferat… Preleukemia Myelodysplastic…
terminated early due to meeting end point with fewer patients than anticipated
-
NCT00402415
Details
2013-12-18
Interventional
118 
Sirolimus Sunitinib
Neoplasms Tumors
-
-
NCT00324831
Details
2013-12-18
Interventional
3-
Antibodies Antibodies, Mon… Cyclophosphamid… Doxorubicin Immunoglobulin … Immunoglobulins Immunomodulatin… Liposomal doxor… Prednisone Rituximab Sargramostim Vaccines Vincristine
Lymphoma Lymphoma, Large…
-
-
NCT01220258
Details
2013-12-16
Interventional
229 
Azithromycin Ophthalmic Solu…
Conjunctivitis Posterior Bleph…
-
-
NCT01090973
Details
2013-12-16
Interventional
21 
Histone Deacety… Panobinostat
Leukemia Leukemia, Lymph… Leukemia, Lymph… Lymphoma Lymphoma, Mantl… Non-Hodgkin's L…
Pharmaceutical company request.
The study was abandoned after only one patient due to low accrual and the sponsor losing interest in the single-agent. The one patient had disease progression requiring more aggressive treatment and did not complete the study.
NCT00070239
Details
2013-12-16
Interventional
1100 
Alvocidib Fluorodeoxygluc…
Hematologic Neo… Hematopoietic/L… Unspecified Adu…
-
-
NCT01092546
Details
2013-12-13
Interventional
312 
Flutemetamol
Hydrocephalus Hydrocephalus, … Normal Pressure…
Changed focus of the program
-
NCT00033423
Details
2013-12-13
Interventional
1
[1 Refs]
18 
Rituximab
Lymphoma Lymphoma, Non-H…
-
-
NCT00000600
Details
2013-12-13
Interventional
2-
Vitamin E Vitamins
Arteriosclerosi… Atherosclerosis Cardiovascular … Carotid Artery … Cerebrovascular… Heart Diseases Intracranial Ar… Vascular Diseas…
-
-
NCT02010411
Details
2013-12-12
Interventional
217 
Alpha 1-Antitry…
Cystic Fibrosis Fibrosis
Technical problems with measure of CFU's. Outcomes published: PMID:16986483
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NCT01728480
Details
2013-12-11
Interventional
10 
Cisplatin
Carcinoma Carcinoma, Squa… Carcinoma, Verr… Laryngeal Disea… Laryngeal Neopl… Mucositis Nasopharyngeal … Oropharyngeal N… Paranasal Sinus… Recurrence Squamous Cell C… Tongue Neoplasm… Recurrent Squam… Recurrent Squam… Recurrent Squam… Recurrent Squam… Recurrent Squam… Recurrent Squam… Recurrent Verru… Recurrent Verru… Stage III Squam… Stage III Squam… Stage III Squam… Stage III Squam… Stage III Squam… Stage III Squam… Stage III Verru… Stage III Verru… Stage IV Squamo… Stage IV Squamo… Stage IVA Squam… Stage IVA Squam… Stage IVA Squam… Stage IVA Squam… Stage IVA Verru… Stage IVA Verru… Stage IVB Squam… Stage IVB Squam… Stage IVB Squam… Stage IVB Squam… Stage IVB Verru… Stage IVB Verru… Stage IVC Squam… Stage IVC Squam… Stage IVC Squam… Stage IVC Squam… Stage IVC Verru… Stage IVC Verru… Tongue Cancer
Financial Sponsor requested termination
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NCT00528671
Details
2013-12-11
Interventional
41571 
Phenprocoumon
Hemorrhage Mechanical Hear…
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-
NCT00071942
NCT00077571
Details
2013-12-11
Interventional
1-
Metronidazole Vaccines
Breast Neoplasm… Breast Neoplasm… Male Breast Can… Recurrent Breas… Stage IV Breast…
-
-
NCT01370876
Details
2013-12-10
Interventional
2-
Oxaliplatin
Head and Neck N… Cancer of the H… Neoplasms, Head…
company policy
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NCT00801736
2007-007639-17
Details
2013-12-10
Interventional
3648 
Cisplatin Paclitaxel
Lung Neoplasms Lung Cancer
The antibody used did not appear prognostic/predictive based on interim results.
-
NCT00278122
Details
2013-12-10
Interventional
2-
Paclitaxel Sargramostim
Melanoma Melanoma (Skin)
-
-
NCT00107471
Details
2013-12-10
Interventional
1/27 
Lenograstim Topotecan
Central Nervous… Glioma Nervous System … Brain Tumors Central Nervous…
The unpromising experience of the French group with topotecan given at a dosage of 0.4 mg/m2/day over 30 mins w/in 1 hr of radiation (Cancer 2005; 104: 2792).
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NCT01373970
Details
2013-12-06
Interventional
4184 
Pantoprazole
Dyspepsia Functional Dysp…
-
-
NCT01900795
Details
2013-12-05
Interventional
2114 
Ibuprofen
Pain, Postopera… Postsurgical Pa…
Terminated early due to administrative reasons not related to safety.
-
NCT00857649
Details
2013-12-05
Interventional
3
[1 Refs]
369 
Memantine
Alzheimer Disea… Alzheimer's Dis…
-
Long recruitment, premature termination, substantial protocol changes; baseline imbalances (concomitant medication and severity of agitation). Variability across sites in reported events frequency (50% of agitation reports from a single site)