Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00780325
Details
2014-02-06
Interventional
1
[2 Refs]
26 
Acetazolamide Celecoxib Naproxen
Healthy Volunte…
A total of three parts were planned for this study. The sponsor funded only Part 1, so that neither Part 2 nor Part 3 of this study has been conducted.
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NCT00004227
Details
2014-02-06
Interventional
3
[4 Refs]
32 
Cetuximab
Head and Neck N… Head and Neck C…
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NCT00113048
Details
2014-02-05
Interventional
1-
Alemtuzumab
Hematologic Neo… Neoplasms Hematologic Mal…
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NCT01933061
Details
2014-02-04
Interventional
20 
Albumin-Bound P… Paclitaxel
Melanoma Metastatic Mela…
Strategic decision not to proceed with the opening of this study. There are no concerns over the safety or quality of the investigational products involved.
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NCT00832507
Details
2014-02-04
Interventional
2162 
Cicletanine
Familial Primar… Hypertension Pulmonary Arter…
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NCT00394992
Details
2014-02-04
Interventional
379 
Bevacizumab Capecitabine Oxaliplatin
Colorectal Neop… Liver Neoplasms Neoplasm Metast… Colorectal Canc… Liver Metastase…
Data from the C08 study and Avant study
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NCT01384383
Details
2014-02-03
Interventional
2248 
Ledipasvir
Hepatitis Hepatitis A Hepatitis C Hepatitis C, Ch… Hepatitis, Chro… Virus Diseases Chronic Hepatit…
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NCT00997672
2009-016377-15
Details
2014-02-03
Interventional
210 
Lithium Carbona…
Atrophy Multiple System… Shy-Drager Synd…
Data Monitoring Committee decision on 22nd August 2011 for safety issues
Limitation of the study is small sample size of nine randomized patients. This may have determined uneven distribution of AEs due to random variation. Taking into account these limitations, we do not encourage future studies with lithium in MSA.
NCT00511901
Details
2014-01-31
Interventional
422 
Epoetin Alfa
Anemia
Study enrollment was suspended in response to an FDA alert regarding the study drug. The study was subsequently terminated
Limited number of eligible subjects, burdensome protocol requirements impeded recruitment, controversy concerning safety of epoetin alpha which led to early termination of study
NCT00686478
Details
2014-01-30
Interventional
30 
Interferon alph… Interferon-alph… Interferons
Cicatrix, Hyper… Hypertrophy Burn Hypertrophic Sc…
The trial is not being done at this time
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NCT01288131
Details
2014-01-29
Interventional
38 
Cyclophosphamid… Cyclosporine Cyclosporins Mycophenolic Ac…
Anti-r-HuEpo As…
We observed >90 % efficacy in cyclophosphamide and Prednisolone group for treatment of anti-i-HuEpo associated PRCA
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NCT00989092
Details
2014-01-29
Interventional
2
[1 Refs]
287 
Darbepoetin alf…
Anemia Neoplasms Anemia of Cance… Cancer Carcinoma Non-Myeloid Mal…
slow enrollment and change in product development strategy
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NCT00494533
Details
2014-01-29
Interventional
445 
Treprostinil
Familial Primar… Hypertension Pulmonary Arter…
Safety issues related to outpatient intravenous infusion in India
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NCT01677390
Details
2014-01-28
Interventional
14 
Everolimus
Carcinoma Carcinoma, Rena… Renal Cell Carc…
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NCT00961753
Details
2014-01-28
Interventional
410 
Ibuprofen
Ductus Arterios… Patent Ductus A…
FDA drug recall on July 30, 2010
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NCT02015780
2013-003414-40
Details
2014-01-27
Interventional
30 
Hypoglycemic Ag…
Diabetes Mellit… Kidney Diseases Renal Insuffici… Chronic Kidney … Type 2 Diabetes…
Due to potential concerns about liver safety (See Detailed Description)
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NCT00439140
Details
2014-01-24
Interventional
341 
Botulinum Toxin… Botulinum Toxin… abobotulinumtox…
Urinary Bladder… Overactive Blad…
In agreement with FDA the study was terminated based on data available.
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NCT00165594
Details
2014-01-23
Interventional
1/2-
N-(3-chloro-7-i…
Stomach Neoplas… Gastric Cancer
Study was completed.
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NCT01096199
Details
2014-01-22
Interventional
1-
Cisplatin Everolimus
Cancer
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NCT02040311
Details
2014-01-20
Interventional
4701 
Topiramate
Weight Loss Obesity
Study was terminated early as sponsor wanted to develop an improved formulation.
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