Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00101907
Details
2014-03-20
Interventional
141 
Gemcitabine Motesanib dipho… Panitumumab
Esophageal Canc… Lung Cancer Pancreatic Canc…
Study terminated per recommendation of Data Review Team
-
NCT00866034
Details
2014-03-19
Interventional
4617 
Cetrorelix
In Vitro Fertil… Intracytoplasmi…
Due to limited rate of patient inclusion
The study was terminated prematurely because no significant difference was observed in clinical outcome after 617 inclusions. A much larger population would be needed to detect a small significant difference in favour of either study arm.
NCT00353574
Details
2014-03-18
Interventional
3282 
Darusentan
Hypertension
Study DAR-312 did not meet primary co-endpoints
-
NCT01451723
Details
2014-03-14
Interventional
211 
Epigallocatechi…
Multiple Sclero… Sclerosis
Unusual high frequency of elevated liver function tests.
The study was halted prematurely because of the high incidence of liver function abnormalities
NCT00396383
Details
2014-03-13
Interventional
2
[2 Refs]
9 
Plerixafor
Multiple Myelom… Neoplasms, Plas…
Insufficient cell mobilization for tandem transplants
Study had limited enrollment prior to termination.
NCT00285493
Details
2014-03-13
Interventional
10 
Anti-Bacterial …
Back Pain Low Back Pain
Withdrawn: study halted prematurely, prior to enrollment of first participant
-
NCT00112164
Details
2014-03-13
Interventional
2-
Drotrecogin alf…
Acute Lung Inju… Lung Injury Respiratory Dis… Respiratory Dis… Respiratory Dis…
Per recommendation of the NHLBI DSMB
-
NCT01641575
Details
2014-03-11
Interventional
18 
Gemcitabine
Carcinoma, Non-… Lung Neoplasms Lung Cancer Non-small-cell … Solid Tumor
Registrational study did not meet endpoint so entire program (including CO-101-011) was terminated.
-
NCT00369551
Details
2014-03-06
Interventional
136 
Antibodies Antibodies, Mon… Antineoplastic … Bevacizumab Carboplatin Immunoglobulins Paclitaxel
Adenocarcinoma … Adenocarcinoma,… Carcinoma, Non-… Lung Neoplasms Adenocarcinoma … Bronchoalveolar… Large Cell Lung… Stage II Non-sm… Stage IIIA Non-… Stage IIIB Non-…
-
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NCT01556334
Details
2014-03-05
Interventional
30 
Azithromycin Erythromycin Erythromycin Es… Erythromycin Et… Erythromycin st…
Fetal Membranes… Premature Birth Rupture Preterm Prematu…
Terminated before starting due to need for IND determined by FDA.
-
NCT01131559
Details
2014-03-05
Interventional
3-
Lisdexamfetamin…
Bipolar Disorde… Depression Depressive Diso… Bipolar
Sponsor halted study.
-
NCT01033149
Details
2014-03-05
Interventional
3
[1 Refs]
11 
Acetylcysteine N-monoacetylcys…
Bulimia Bulimia Nervosa
-
-
NCT00742313
Details
2014-03-05
Interventional
450 
Hemostatics
Hemorrhage Bleeding
No statistical differences on study endpoints between groups.
This study was terminated early
NCT01776320
Details
2014-03-04
Interventional
40 
Alprostadil
Erectile Dysfun…
No medication
-
NCT01522196
Details
2014-03-04
Interventional
22 
Varespladib met…
Anemia, Sickle … Sickle Cell Dis… Vaso-occlusive …
change in company plans
-
NCT01079767
2009-014443-36
Details
2014-03-04
Interventional
26 
MTOR Inhibitors Sirolimus Temsirolimus
Liver Neoplasms Liver Cancer
The study treminated early according to DSMB recommendantions
-
NCT00522834
Details
2014-03-04
Interventional
3630 
Paclitaxel
Melanoma
-
-
NCT00666393
Details
2014-03-03
Interventional
30 
Fentanyl
Pain, Postopera… Pediatrics
Program Cancelled.
-
NCT01699854
2012-001540-22
Details
2014-02-26
Interventional
3-
Capsaicin
Persistent Pain…
Expiration of the placebo patch
-
NCT00887640
Details
2014-02-26
Interventional
211 
Diphenhydramine MTOR Inhibitors Promethazine Sirolimus Temsirolimus
Neoplastic Cell… Prostatic Neopl… Prostate Cancer
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