Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01426334
NCT01456988
Details
2014-04-02
Interventional
14 
Cyclosporine Cyclosporins Dasatinib
Leukemia Leukemia, Myelo… Leukemia, Myelo… Leukemia, Myelo… Leukemia, Myelo… Accelerated Pha… Chronic Myeloge… Chronic Phase C… Relapsing Chron…
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NCT01233505
Details
2014-04-02
Interventional
116 
Capecitabine Oxaliplatin Veliparib
Adenocarcinoma Breast Neoplasm… Carcinoma, Ovar… Colonic Neoplas… Cystadenocarcin… Cystadenocarcin… Germinoma Neoplasms Neoplasms, Germ… Ovarian Neoplas… Pancreatic Neop… Rectal Neoplasm… Recurrence Stomach Neoplas… Adenocarcinoma … Adenocarcinoma … BRCA1 Mutation … BRCA2 Mutation … Ovarian Mucinou… Recurrent Breas… Recurrent Colon… Recurrent Gastr… Recurrent Ovari… Recurrent Ovari… Recurrent Pancr… Recurrent Recta… Stage IA Breast… Stage IB Breast… Stage II Breast… Stage IIIA Brea… Stage IIIB Brea… Stage IIIC Brea… Stage IV Breast… Stage IV Colon … Stage IV Gastri… Stage IV Ovaria… Stage IV Ovaria… Stage IV Pancre… Stage IV Rectal… Unspecified Adu…
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NCT00684255
Details
2014-04-01
Interventional
11 
Alemtuzumab Busulfan Fludarabine
Lupus Erythemat… Scleroderma, Di… Scleroderma, Sy… Sclerosis Systemic Lupus … Systemic Sclero…
inactive
Study closed due to low accrual. Did not meet enrollment goals.
NCT00863395
Details
2014-03-31
Interventional
1/26 
Lidocaine
Lymphoma Lymphoma, T-Cel… Lymphoma, T-Cel… Lymphoma, T-Cel… Pruritus Cutaneous T-Cel…
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NCT00203931
Details
2014-03-31
Interventional
255 
Cetuximab Pemetrexed
Carcinoma, Non-… Lung Neoplasms Non-small Cell …
Slow accrual and evidence from other studies showing benefit of early initiation of pemetrexed after first-line therapy
-
NCT00088933
Details
2014-03-31
Interventional
160 
Docetaxel Metronidazole Sargramostim Vaccines
Carcinoma, Non-… Colonic Neoplas… Lung Neoplasms Rectal Neoplasm… Recurrence Small Cell Lung… Extensive Stage… Recurrent Colon… Recurrent Non-s… Recurrent Recta… Recurrent Small… Stage IV Colon … Stage IV Non-sm… Stage IV Rectal…
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NCT01287221
Details
2014-03-28
Interventional
3
[1 Refs]
100 
Riboflavin Rifampin
Atrophy Multiple System… Shy-Drager Synd…
DSMB recommended stopping the study after an interim analysis of the primary endpoint revealed that futility criteria were met.
The study was terminated early; the Data Safety and Monitoring Board recommended stopping the study after an interim analysis of the primary endpoint revealed that futility criteria were met.
NCT01117129
2008-002381-55
Details
2014-03-28
Interventional
42 
Methotrexate Rituximab
Arthritis Arthritis, Rheu… Rheumatoid Arth…
This study was prematurely terminated as 2 patients were recruited and both of them withdrawn from the study before reaching the primary end point.
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NCT02098148
Details
2014-03-27
Interventional
20 
Xenon
Compulsive Pers… Obsessive-Compu…
Withdrawn. Unable to set up appropriate infrastructure to support study.
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NCT00372762
Details
2014-03-27
Interventional
30 
Bumetanide Furosemide
Heart Failure
Due to changes within the research program this study is not feasible at this time
-
NCT01515826
Details
2014-03-26
Interventional
30 
BB 1101 Dexamethasone Dexamethasone 2… Dexamethasone a… Moxifloxacin Norgestimate, e… Ophthalmic Solu… Pharmaceutical …
Cataract Cataracts
Management decision
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NCT01458015
Details
2014-03-26
Interventional
45 
Oxycodone Tapentadol
Neuralgia Peripheral Nerv… Peripheral Neur…
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NCT01326078
Details
2014-03-26
Interventional
2/30 
Propofol
Leukemia
The Sponsor has no interest in continuing the study.
-
NCT01308047
Details
2014-03-26
Interventional
30 
Bupivacaine
Fracture of Low…
The Sponsor has no interest in continuing the study.
-
NCT01303107
Details
2014-03-26
Interventional
30 
Bupivacaine
Cesarean Delive…
The Sponsor has no interest in continuing the study.
-
NCT00751036
2010-019806-18
Details
2014-03-26
Interventional
394 
Imatinib Mesyla… Nilotinib
Gastrointestina…
-
Patients were limited (planned 300, Actual 94). Early termination of study; not sufficient power to test the original primary hypothesis with respect to PFS. Only descriptive analyses were carried out for this study.
NCT00239681
Details
2014-03-24
Interventional
317802 
Rosuvastatin Ca…
Hypersensitivit… Elevated High-s…
See detailed description for reason.
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NCT01244880
Details
2014-03-21
Interventional
14 
Ketamine
Healthy
See termination reason in detailed description.
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NCT00441168
2006-001709-27
Details
2014-03-21
Interventional
230 
Bortezomib Dexamethasone Doxorubicin Liposomal doxor… Vincristine
Multiple Myelom… Neoplasms, Plas…
TRIAL STOPPED due to a change in standard of care and the required patient numbers could no longer be achieved
Due to a substantial decline in the use of the VAD regimen as standard of care, recruitment of the study was halted at 30 subjects. It was not possible to statistically evaluate any long term efficacy parameter.
NCT00355251
2005-005356-41
Details
2014-03-20
Interventional
45 
Atorvastatin
Infections HIV Infections
On the basis of published results of SMART study, it has been observed that the results are worse in patients who have interrupted their treatments.
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