Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00305162
Details
2014-05-08
Interventional
3
[1 Refs]
8882 
Cangrelor Clopidogrel
Acute Coronary … Infarction Myocardial Infa… Acute Coronary … Myocardial Infa…
Insufficient evidence of the clinical effectiveness of cangrelor
Discontinued per prespecified stopping rules after the 70% interim analyses was conducted indicating the trial was not likely to meet the goal of demonstrating superiority to clopidogrel administered as usual care. No safety issues were identified.
NCT00852059
Details
2014-05-07
Interventional
432 
Methylphenidate
Attention Defic… ADHD
Diffculties to recruit anticipated study size, now analysis
-
NCT00784836
Details
2014-05-07
Interventional
33 
Interferon beta… Interferon-beta Interferons
Multiple Sclero… Sclerosis
Terminated early by Sponsor for business reasons unrelated to safety.
Early termination with partial data from 3 subjects, therefore, no statistical analysis performed.
NCT00406575
Details
2014-05-07
Interventional
211 
Methocarbamol
Heart Failure Congestive Hear…
-
-
NCT01264770
2010-023692-26
Details
2014-05-06
Interventional
2644 
Adalimumab
Arthritis Arthritis, Rheu… Rheumatoid Arth…
AZ decision to discontinue fostamatinib development in RA; rights to fostamatinib returned to Rigel Pharmaceuticals.
-
NCT00942539
Details
2014-05-06
Interventional
212 
Midazolam
Anxiety Pain
-
-
NCT00588822
Details
2014-05-06
Interventional
221 
Rituximab
Monoclonal Gamm… Paraproteinemia… Peripheral Nerv… Precancerous Co… Precancerous Co…
Discontinuation due to the high response rate at the 1st stage and slow accrual.
The study was discontinued at the first stage to the high response rate and slow accrual.
NCT00907829
Details
2014-05-05
Interventional
20 
Lidocaine
Stroke Cerebrovascular…
Methods unexpectedly required additional refinement that precluded subject enrollment.
-
NCT00385138
Details
2014-05-05
Interventional
3
[1 Refs]
5364 
Cangrelor Clopidogrel
Acute Coronary … Atherosclerosis Acute Coronary …
Insufficient evidence of the clinical effectiveness of cangrelor
Discontinued per prespecified stopping rules after the 70% interim analyses was conducted indicating the trial was not likely not meet the goal of demonstrating superiority to clopidogrel administered as usual care. No safety issues were identified.
NCT01179737
NCT01531270
2010-019883-36
Details
2014-05-01
Interventional
223 
Nilotinib
Familial Primar… Hypertension Pulmonary Arter…
Study was terminated due to serious adverse event (SAE)
-
NCT00933985
Details
2014-05-01
Interventional
122 
Dexrazoxane Doxorubicin Liposomal doxor… Obatoclax Razoxane Vincristine
Blast Crisis Burkitt Lymphom… Immunoblastic L… Intraocular Lym… Leukemia Leukemia, Hairy… Leukemia, Lymph… Leukemia, Myelo… Leukemia, Myelo… Lymphoma Lymphoma, B-Cel… Lymphoma, Extra… Lymphoma, Large… Lymphoma, Large… Lymphoma, Large… Lymphoma, Non-H… Lymphoma, T-Cel… Lymphoma, T-Cel… Lymphoma, T-Cel… Lymphomatoid Gr… Mycoses Mycosis Fungoid… Plasmablastic L… Precursor Cell … Recurrence Sezary Syndrome Acute Leukemias… Acute Undiffere… Angioimmunoblas… Blastic Phase C… Childhood Burki… Childhood Chron… Childhood Diffu… Childhood Immun… Childhood Nasal… Cutaneous B-cel… Hepatosplenic T… Noncutaneous Ex… Peripheral T-ce… Recurrent Child… Recurrent Child… Recurrent Child… Recurrent Child… Recurrent Child… Recurrent Child… Recurrent Child… Recurrent Cutan… Recurrent Mycos… Recurrent/Refra… Refractory Chro… Refractory Hair… Relapsing Chron… Small Intestine… Unspecified Chi…
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NCT01110330
Details
2014-04-29
Interventional
3583 
Ketoconazole
Tinea Tinea Pedis
Unexpected discordant results between the KOH microscopy and mycological culture tests at three study sites in the UK.
The study was terminated prematurely by the sponsor due to significant discrepancies between potassium hydroxide and mycological culture results.
NCT00521989
Details
2014-04-29
Interventional
2279 
Dipyridamole Methylprednisol… Methylprednisol… Methylprednisol… Prednisolone Prednisolone ac… Prednisolone he… Prednisolone ph…
Osteoarthritis Osteoarthritis,… Knee Osteoarthr…
CRx-102-006 study results, negative
-
NCT02016547
2012-005493-66
Details
2014-04-25
Interventional
4-
Abciximab Tissue Plasmino…
Infarction Infarction, Mid…
-
-
NCT01646515
Details
2014-04-24
Interventional
341 
Udenafil
Heart Failure Heart Failure, … Systolic Murmur… Systolic Heart …
Substantial benefit was observed in the active treatment group
-
NCT00819910
Details
2014-04-24
Interventional
4
[2 Refs]
41 
Fenofibrate Rosiglitazone
Hyperlipidemias Hyperlipoprotei… Hypertriglyceri… Hypertriglyceri… Non Diabetic Su…
Slow recruitment and increase in deployment overseas limiting follow up
First, the study was terminated early per FDA recommendations restricting rosiglitazone use. Second, recruitment of patients was slow due to deployment restraints.
NCT00593957
Details
2014-04-23
Interventional
238 
Dextromethorpha… Levomethorphan
Rett Syndrome Syndrome
Study changed to a placebo controlled trial of dextromethorphan
The trial was terminated due to the FDA requiring a placebo controlled trial instead of the ongoing open label trial. As recruitment was delayed,the total number of participants was also less than anticipated.
NCT00997087
Details
2014-04-22
Interventional
211 
Flumazenil
Compulsive Pers… Obsessive-Compu… Obsessive Compu…
Study completed and data was inconclusive.
-
NCT01737879
Details
2014-04-21
Interventional
441 
Epoetin Alfa
Anemia
Terminated: Test article, Omontys, was recalled from the market; Enrollment has halted prematurely and will not resume; participants are no longer being treated
-
NCT01514981
Details
2014-04-21
Interventional
17 
Mogamulizumab
Asthma
Administrative decision
-