Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

Filter:

Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
Free Text
Annotations

7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02171546
Details
2014-06-24
Interventional
142 
Dabigatran Fexofenadine Quinidine Quinidine gluco…
Healthy
-
-
NCT01534806
Details
2014-06-24
Interventional
40 
Ketorolac
Emergencies Migraine Disord… Migraine
Drug is backordered;
-
NCT01435902
Details
2014-06-23
Interventional
30 
Fluticasone Xhance
Asthma
Study was cancelled prior to enrolling any subjects
-
NCT01360827
Details
2014-06-17
Interventional
113 
Cetuximab Cisplatin Fluorouracil
Carcinoma Carcinoma, Squa… Squamous Cell C… Squamous Cell C…
Study terminated due to potential safety concerns in combination with platinum-based therapies
-
NCT00227292
NCT00294333
2005-001673-10
Details
2014-06-17
Interventional
4
[2 Refs]
0 
Escitalopram
Back Pain Depression Low Back Pain
Mutual agreement between Sponsor and Investigator.
-
NCT00000372
Details
2014-06-12
Interventional
30 
Clozapine Cycloserine Glycine
Schizophrenia
Pairing D-Cycloserine with Clozapine was found to worsen negative side effects in patients with Schizophrenia, so the study was suspended.
-
NCT01254656
Details
2014-06-09
Interventional
2108 
Efavirenz Etravirine
Infections HIV-1
See termination reason in detailed description.
The study was terminated on 29 Jan 13 due to termination of lersivirine development program. All participants were enrolled from study A5271015 except one from A5271022. Above summarized outcome measures included participants enrolled from A5271015.
NCT01252355
2010-023172-12
Details
2014-06-09
Interventional
3534 
Interferon-beta Interferons Teriflunomide
Multiple Sclero… Sclerosis Multiple Sclero…
Sponsor decision to prematurely stop the study, not linked to any safety concern.
The early termination of study with reduced sample size and participant follow-up impacts the power and interpretability, and limits the ability to assess the overall benefit/risk of adjunctive therapy. Termination was not due to any safety concerns.
NCT01149993
Details
2014-06-09
Interventional
40 
Antilymphocyte … Mycophenolic Ac… Thymoglobulin
Ischemia Reperfusion Inj… Wounds and Inju… Kidney Transpla… Renal Transplan…
FDA clinical hold, IND withdrawn.
-
NCT00729833
Details
2014-06-09
Interventional
145 
Sunitinib
Neoplasms Advanced Cancer Advanced Solid …
See termination reason in detailed description.
This study was terminated prematurely. Subsequently, ADA samples were not assayed and the pharmacokinetics of sunitinib plus its metabolite were not analyzed.
NCT00689052
Details
2014-06-09
Interventional
261 
Dexpramipexole Pramipexole
Fibromyalgia Myofascial Pain…
-
Early termination leading to no number of subjects analysed for any outcome measure
NCT00603525
Details
2014-06-09
Interventional
3169 
Ofatumumab
Arthritis Arthritis, Rheu…
Ofatumumab IV trials in RA were prematurely terminated because GSK refocused clinical development of autoimmune indications on the subcutaneous delivery.
-
NCT00114374
Details
2014-06-09
Interventional
3-
Escitalopram
Anxiety Disorde… Stress Disorder… Stress Disorder… Wounds and Inju… Anxiety Disorde…
-
-
NCT00087373
Details
2014-06-09
Interventional
228 
Metronidazole
Melanoma Recurrent Melan… Stage IV Melano…
-
-
NCT00956293
2008-005109-20
Details
2014-06-06
Interventional
4207 
Basiliximab Cyclosporine Cyclosporins Everolimus Mycophenolic Ac…
Renal Transplan…
The study was terminated because the required sample size of 240-260 de novo senior renal transplant patients was not achieved within a reasonable time.
-
NCT00628355
Details
2014-06-06
Interventional
430 
Lidocaine
Myofascial Pain… Pelvic Pain
Lidocaine injection group showed significant improvement in pain
Early termination leading to small numbers of subjects analyzed.
NCT01533818
Details
2014-06-03
Interventional
4963 
Amoxicillin
Respiratory Asp… Tachypnea Fast Breathing …
The study was stopped by DSMB based on high treatment failure rate in placebo compared to active drug.
-
NCT01231854
2009-017520-88
Details
2014-06-03
Interventional
415 
Alitretinoin Cyclosporine Cyclosporins
Dermatitis Atopic Dermatit…
delayed start of the trial, both treatment options already have market authorizations, study medication expired
-
NCT00198172
Details
2014-06-03
Interventional
2-
Epirubicin
Neoplasms, Germ… Germ Cell Tumor
Accrual Goal Met
-
NCT02055196
Details
2014-06-02
Interventional
10 
Irinotecan
Astrocytoma Glioblastoma Gliosarcoma Oligodendroglio… Recurrence Adult Anaplasti… Adult Anaplasti… Adult Giant Cel… Adult Glioblast… Adult Gliosarco… Recurrent Adult…
New study written
-