Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02182401
Details
2014-07-18
Interventional
137 
Midazolam Tolbutamide
Healthy
-
-
NCT02181920
Details
2014-07-18
Interventional
46 
Diclofenac Dipyrone
Chronic Pain Pain
-
-
NCT02177370
Details
2014-07-18
Interventional
319 
Fenoterol
Asthma
-
-
NCT01129960
2010-019100-23
Details
2014-07-18
Interventional
3332 
Eslicarbazepine…
Diabetic Neurop… Neuralgia Painful Diabeti…
-
-
NCT00744653
Details
2014-07-18
Interventional
2
[1 Refs]
17 
Bleomycin
Breast Neoplasm… Recurrence Breast Cancer
Primary endpoint measure not suitable for evaluation
Early termination due to too few objective respondes using the primary endpoint.
NCT00720629
Details
2014-07-18
Interventional
28 
Antilymphocyte … Methotrexate Tacrolimus Thymoglobulin Visilizumab
Graft vs Host D… Graft Versus Ho…
-
Study closed early during the first stage, did not proceed to the second stage comparison as planned. Investigators exercised right to close the study prematurely for lack of efficacy, although no protocol-defined end points had been met.
NCT02081183
Details
2014-07-17
Interventional
316 
Cyclophosphamid… Mycophenolic Ac… Prednisone
Lupus Nephritis Nephritis
-
Data were not analyzed because the study was terminated early.
NCT00927212
Details
2014-07-17
Interventional
25 
Ammonium trichl…
Dermatitis Dermatitis, Ato… Eczema Atopic Dermatit…
The trial started and halted due sponsor's considerations.
-
NCT00547911
Details
2014-07-17
Interventional
1/214 
Carbidopa Droxidopa Entacapone
Autonomic Nervo… Multiple System… Nervous System … Parkinson Disea… Primary Dysauto… Shy-Drager Synd…
Study terminated due to contamination droxidopa
Study was prematurely terminated due to a small amount of DOPAL contamination in the droxidopa. Because of the early termination only a small number of subjects were enrolled in each condition. Recently, the FDA has approved droxidopa.
NCT01125930
Details
2014-07-16
Interventional
368 
Tretinoin
Rosacea
Due to slow recruitment and sponsor request study ended early
Early termination of study due to slow recruitment and sponsor request resulted in smaller number of subjects analyzed.
NCT01491633
Details
2014-07-15
Interventional
2
[1 Refs]
5 
Dasatinib
Lung Neoplasms Squamous Cell L…
Safety issues/concerns per DF/HCC PI
Due to the toxicity of the study agent no subjects were evaluable for response
NCT01200264
Details
2014-07-15
Interventional
20 
Apremilast
Psoriasis Chronic Plaque …
Contract never executed; withdrawn by sponsor
-
NCT02184286
Details
2014-07-14
Interventional
15 
Nevirapine Saquinavir
HIV Infections
-
-
NCT02182765
Details
2014-07-14
Interventional
18 
Abacavir Amprenavir Nevirapine
HIV Infections
-
-
NCT02176200
Details
2014-07-14
Interventional
33 
Fenoterol Fenoterol, ipra… Ipratropium
Lung Diseases Lung Diseases, … Pulmonary Disea…
-
-
NCT02176187
Details
2014-07-14
Interventional
33 
Fenoterol Fenoterol, ipra… Ipratropium
Lung Diseases Lung Diseases, … Pulmonary Disea…
-
-
NCT01904253
2012-004793-26
Details
2014-07-14
Interventional
218 
Amrubicin Topotecan
Lung Neoplasms Small Cell Lung… Small Cell Lung…
The preliminary data does not suggest any safety signal, but an ad hoc interim analysis showed an imbalance of PFS between the two arms
-
NCT01418742
Details
2014-07-14
Interventional
211 
Doxycycline Panitumumab
Carcinoma Colorectal Neop… Colorectal Carc…
Recruitement did not meet expectations. Prev. differentiation of RAS-wild-type and mutated RAS are not in accordance with the scientific rank anymore.
-
NCT01301612
Details
2014-07-14
Interventional
20 
Cisplatin Nimotuzumab
Adenocarcinoma Carcinoma Carcinoma, Aden… Uterine Cervix …
Regulatory requirement. A phase III study is being designed.
-
NCT00709618
Details
2014-07-14
Interventional
244 
Lapatinib Vinorelbine
Breast Neoplasm… Neoplasms, Brea…
Evolving standard of care practices in this disease setting was limiting enrolment and leading to a delay in delivering this study information to the public.
The study was terminated due to low screening and a low enrollment rate after 3 years.