Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01209715
Details
2014-08-01
Interventional
20 
Fluticasone Fluticasone-Sal… Salmeterol Xina…
Respiratory Asp… COPD
Due to the ubiquitous use of ICS in the treatment of COPD in 2012, it was hard to find the study population.
-
NCT00746941
Details
2014-07-31
Interventional
1/2
[1 Refs]
37 
Mefloquine
Leukoencephalop… Leukoencephalop… Progressive Mul…
Primary endpoint not achieved
From ongoing analysis, it became clear, based on conditional power calculations, that the study would not reach its primary endpoint, a decrease of JC viral load in CSF with mefloquine treatment; therefore, the study was terminated early.
NCT00499369
Details
2014-07-31
Interventional
372 
Antibodies Antibodies, Mon… Antineoplastic … Bevacizumab Cetuximab Fluorouracil Immunoglobulins Irinotecan Leucovorin Levoleucovorin
Colonic Neoplas… Rectal Neoplasm… Recurrence Recurrent Colon… Recurrent Recta… Stage IVA Colon… Stage IVA Recta… Stage IVB Colon… Stage IVB Recta…
Due to inadequate accrual, study was terminated and limited outcome data was reported.
Due to inadequate accrual, study was terminated and limited outcome data was reported.
NCT02127684
Details
2014-07-30
Interventional
20 
Ranibizumab
Edema Macular Edema Persistent Diab…
sponsor determined study design would not produce useful results
-
NCT00787852
Details
2014-07-30
Interventional
111 
Albumin-Bound P… Dasatinib Paclitaxel
Carcinoma, Non-… Lung Neoplasms Non-Small Cell …
for efficacy and safety reasons
-
NCT01326117
Details
2014-07-29
Interventional
40 
Tadalafil
Gastroparesis Vomiting Diabetic Gastro… Nausea
lack of patients who meet inclusion criteria; there was one screen failure
-
NCT00005072
Details
2014-07-29
Interventional
1/225 
Interleukin-2
Prostatic Neopl… Prostate Cancer
Development in prostate cancer indication halted
-
NCT00004050
Details
2014-07-29
Interventional
213 
Interleukin-2
Prostatic Neopl… Prostate Cancer
Development in prostate cancer indication halted
-
NCT01151787
Details
2014-07-25
Interventional
335 
Amitriptyline Cyclobenzaprine
Migraine Disord… Chronic Migrain…
Study was never initiated under new location/provider group. Contract to continue was never signed between TEVA and Kennedy Headache Center
-
NCT01078376
2009-013165-25
Details
2014-07-25
Interventional
129 
Azilsartan medo…
Hypertension
Business Decision (see below)
The study was discontinued without complete enrollment of Cohort 3. Therefore, PK modeling will be used to determine the appropriate doses in children 1 to <6 years of age, in lieu of completing Cohort 3.
NCT00429702
Details
2014-07-25
Interventional
27 
Dexamethasone Diphenhydramine Lorazepam Ondansetron Promethazine
Nausea Vomiting Unspecified Chi…
Closed due to poor accrual and lack of feasibility to finish study per DSMB
The study was closed prior to completing enrollment based on the recommendation by the SunCoast CCOP Research Base Data Safety Monitoring Board for a lack of feasibility and poor enrollment.
NCT00184054
Details
2014-07-25
Interventional
211 
Arsenic Trioxid… Ascorbic Acid
Leukemia Leukemia, Myelo… Leukemia, Myelo… Acute Myelogeno…
Competing studies
-
NCT01021943
Details
2014-07-24
Interventional
2-
Spironolactone
Kidney Transpla…
-
-
NCT00925548
2008-005544-17
Details
2014-07-24
Interventional
316 
Cyclophosphamid…
Breast Neoplasm… Breast Cancer
See termination reason in the below Purpose statement
Efficacy data were not analyzed as the trial was prematurely terminated following the clinical hold on the investigational new drug application for tecemotide (L-BLP25)
NCT00373204
Details
2014-07-24
Interventional
250 
Motexafin gadol…
Carcinoma, Non-… Lung Neoplasms Lung Cancer
-
-
NCT01534949
Details
2014-07-23
Interventional
11 
Rituximab
Lymphoma Lymphoma, B-Cel… Lymphoma, Large… Diffuse Large B…
-
-
NCT00957242
Details
2014-07-23
Interventional
3145 
Warfarin
Fibrosis Idiopathic Pulm… Pulmonary Fibro…
Excess of mortality in the treatment group created safety concerns.
-
NCT00851552
Details
2014-07-21
Interventional
29 
Bortezomib Doxorubicin Liposomal doxor… Rituximab
Lymphoma Lymphoma, Large…
Lack of sponsor support
Due to the study's early termination and inadequate number of patients, no patients were analyzed.
NCT00545948
Details
2014-07-21
Interventional
231 
Cisplatin Pemetrexed Vinorelbine
Carcinoma, Non-…
Study terminated due to reproducibility issues with genomics prediction model.
-
NCT00224419
Details
2014-07-21
Interventional
4
[1 Refs]
181 
Nicotine
Pregnancy Smoking
was terminated due to meeting a priori stopping rule set by DSMB
-