Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02215044
Details
2014-08-13
Interventional
112 
Gemcitabine
Pancreatic Neop…
-
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NCT02145689
2013-002327-42
Details
2014-08-13
Interventional
30 
Botulinum Toxin… Botulinum Toxin… abobotulinumtox…
Muscle Spastici… Stroke
The study was withdrawn prior to enrollment due to corporate decision.
-
NCT02095574
Details
2014-08-13
Interventional
10 
Venetoclax
Lymphoma Lymphoma, Non-H… Relapsed/Refrac…
This study will now be conducted in healthy volunteers.
-
NCT00381017
2005-003876-39
Details
2014-08-13
Interventional
30 
Interferon alph… Interferon-alph… Interferons Peginterferon a…
Hepatitis Hepatitis A Hepatitis C Liver Cirrhosis HIV Infections
Non-protocol feasibility
-
NCT02214095
Details
2014-08-12
Interventional
140 
Anti-Inflammato…
Chronic Periodo… Periodontitis
had been finished
-
NCT01810575
Details
2014-08-12
Interventional
216 
Alprostadil
Erectile Dysfun…
Re-assessment of study
-
NCT01430585
Details
2014-08-12
Interventional
214 
Letrozole
Breast Neoplasm… Advanced Breast… Early Breast Ca…
See termination reason in detailed description.
Study was prematurely terminated due to PF-04691502 tolerability findings that prompted Sponsor to re-evaluate strategic goals of program. Unexpected frequency of severe skin toxicity was observed and no participant was enrolled in phase 2 of study.
NCT00265915
Details
2014-08-12
Interventional
2-
Rituximab Sargramostim
Leukemia Leukemia, Lymph… Leukemia, Lymph…
-
-
NCT01156051
NCT01153178
Details
2014-08-11
Interventional
429 
Guanfacine
Attention Defic… Hyperkinesis Sleep Initiatio… Sleep Wake Diso… Attention Defic… Attention-Defic… Insomnia Sleep Disorders
extended beyond completion date; chose to close out rather than renew IRB review
-
NCT00812435
Details
2014-08-11
Interventional
322 
Eptifibatide
Infarction Myocardial Infa…
-
-
NCT01499667
2011-001442-15
Details
2014-08-08
Interventional
3142 
Fingolimod Hydr…
Multiple Sclero… Multiple Sclero… Sclerosis Relapsing Remit…
Based on recent publications, determination of natalizumub washout period was no longer relevant.
Study was terminated due to new data on nataluzimab washout prior to treatment with other disease modifying treatments. The power to detect statistically significant differences between the washout groups based on the (-)binomial is estimated 30-40%.
NCT01318642
2010-023978-39
Details
2014-08-08
Interventional
210 
Gemcitabine
Adenocarcinoma Adenocarcinoma … Locally Advance… Unresectable
NCT01318642: Planned independent DMC Interim review: ended for futility w/no safety concerns
-
NCT01189253
2009-014889-26
Details
2014-08-08
Interventional
2/3133 
Doxorubicin Liposomal doxor… Trabectedin
Sarcoma
Results of step1: none of the experimental arms fulfills expectations and the study will not continue as a phase III.
-
NCT00911326
Details
2014-08-08
Interventional
3101 
Dextrans Technetium Tc 9…
Carcinoma Carcinoma, Squa… Squamous Cell C… Head and Neck S…
The trial was terminated early based on an interim review by the Data and Safety Monitoring Committee for positive efficacy outcome and no safety concerns.
The study was prospectively structured to include an interim analysis at 33.3% enrollment. The trial was terminated early based on an interim review by the Data and Safety Monitoring Committee for positive efficacy outcome and lack of safety concern.
NCT02149095
Details
2014-08-07
Interventional
10 
Treprostinil
PAH
Study will not be conducted
-
NCT02209701
Details
2014-08-06
Interventional
13 
Porfiromycin
Head and Neck N…
-
-
NCT01452347
2010-022685-27
Details
2014-08-06
Interventional
2328 
Dabigatran Warfarin
Heart Valve Dis…
-
This study was terminated prematurely due to safety concerns arising during conduct of the trial.
NCT00944333
Details
2014-08-05
Interventional
31378 
Clopidogrel
Angina Pectoris Ischemia Silent Ischemia
STOP due to recent data in literature questioning the need to continue DAP beyond six months in patients with stable coronary artery stenting with DES.
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NCT01118663
Details
2014-08-04
Interventional
317 
Acetylcysteine Edetic Acid N-monoacetylcys… Pentetic Acid
Drug Overdose Acetaminophen O…
-
-
NCT01282047
2010-022898-33
Details
2014-08-01
Interventional
212 
Lenalidomide
Acquired Immuno… Communicable Di… HIV Infections Infections Xeroderma Pigme… HIV Infection A…
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