Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01333137
Details
2014-09-04
Interventional
111 
Carboplatin Gemcitabine
Breast Neoplasm… Triple Negative… Breast Cancer
-
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NCT01866709
Details
2014-09-03
Interventional
432 
Polystyrene sul…
Hyperkalemia
Risk/benefit determination showed study revealed negative safety issues.
Due to the high frequency of adverse events in the SPS group, the independent Data Monitoring Committee (iDMC) recommended termination of the study.
NCT01346930
Details
2014-09-03
Interventional
20 
Macitentan
Fibrosis Idiopathic Pulm… Pulmonary Fibro…
Due to Protocol AC-055B201 (MUSIC) not meeting it's primary end point
-
NCT00252967
Details
2014-09-03
Interventional
3
[1 Refs]
64 
Atorvastatin
Atrial Fibrilla… Inflammation
Insufficient power to show therapy difference at interim analysis.
Limited enrollment; recurrence rate of AF was slightly higher than other trials indicated that the study sample may be a high-risk population.
NCT02229760
Details
2014-09-01
Interventional
1/23 
Ritonavir Tipranavir
HIV Infections
-
-
NCT00884390
Details
2014-09-01
Interventional
4208 
Factor VIII
Hemophilia A
See termination reason in detailed description.
The study was terminated early by agreement with the EMA before full recruitment was attained, but this is not considered to affect the overall results and the ability of the study to address its objectives.
NCT01810302
Details
2014-08-29
Interventional
22 
Nicardipine
Vasospasm, Intr… Cerebral Vasosp…
Unable to secure drug.
This single center study was terminated early due to inability to maintain an adequate drug supply; therefore, statistical analysis of the 2 participants was not done.
NCT01284205
Details
2014-08-29
Interventional
30 
BCG Vaccine
Urinary Bladder… Bladder Cancer
This indication is not being pursued at this point in time.
-
NCT00962936
Details
2014-08-29
Interventional
1/213 
Pidilizumab
Hepatitis Hepatitis A Hepatitis C Hepatitis C, Ch… Hepatitis, Chro… Infections Chronic Hepatit…
-
-
NCT00682344
2007-000796-42
Details
2014-08-28
Interventional
37 
Levobupivacaine
Surgical Pathol…
-
-
NCT00544778
Details
2014-08-28
Interventional
27 
Dexrazoxane Doxorubicin Ifosfamide Irinotecan Liposomal doxor… Razoxane
Osteosarcoma Sarcoma
The study was terminated prematurely due to withdrawal of support by the sponsor.
The study was terminated…protocol objectives not met. It was closed prematurely due to withdrawal of support by the sponsor. Subjects have been followed, but there is not enough data generated to continue following the subjects."
NCT00509366
Details
2014-08-28
Interventional
2101 
Cisplatin Docetaxel Gemcitabine Pemetrexed
Carcinoma, Non-… Lung Neoplasms Non Small Cell …
Study terminated due to reproducibility issues with genomics prediction model.
The microarray-based prediction model of chemotherapy sensitivity, used to allocate patients into the cisplatin treatment arms, was irreproducible and inaccurate. Quality of life measurements were incomplete and could not be analyzed.
NCT00225173
Details
2014-08-27
Interventional
2-
Bleomycin Cyclophosphamid… Doxorubicin Etoposide Etoposide phosp… Gemcitabine Prednisone Vinblastine Vincristine Vinorelbine
Hodgkin Disease
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-
NCT02170519
Details
2014-08-26
Interventional
427 
Iloprost
Hypertension Hypertension, P… Pulmonary Hyper…
Project was completed
-
NCT01365910
Details
2014-08-26
Interventional
230 
Tyrosine Kinase…
Colonic Neoplas… Rectal Neoplasm… Recurrence Recurrent Colon… Recurrent Recta… Stage IVA Colon… Stage IVA Recta… Stage IVB Colon… Stage IVB Recta…
Interim analysis determined the study did not meet criteria to proceed
-
NCT00667277
Details
2014-08-22
Interventional
2
[1 Refs]
13 
Bevacizumab
Primary Myelofi… Myelofibrosis
lack of response activity in the setting of an unacceptable toxicity profile
The study was terminated due to lack of response activity in the setting of an unacceptable toxicity profile at the completion of the first stage.
NCT00683917
Details
2014-08-21
Interventional
210 
Leuprolide
Leiomyoma Myofibroma Uterine Fibroid…
Repros stopped the study for safety and FDA put the study on hold for safety.
The study was prematurely terminated for safety reasons (Proellex studies were put on clinical hold due to liver toxicity). Sponsor was unable to pay vendor, and was therefore not provided with any study data.
NCT00385827
2006-001671-38
Details
2014-08-20
Interventional
2106 
Mitoxantrone Prednisone Siltuximab
Prostatic Neopl… Cancer, Prostat…
Prematurely stopped after Independent Data Monitoring Committee (IDMC) evaluation for lack of efficacy.
Results of few secondary endpoints were not reported as the study was terminated early due to the premature suspension and subsequent halting of study enrollment.
NCT01442168
Details
2014-08-19
Interventional
1/253 
Atovaquone
Malaria Malaria, Falcip…
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NCT00713765
2008-002847-17
Details
2014-08-15
Interventional
133 
Donepezil
Alzheimer Disea… Alzheimer's Dis…
Ended prematurely - The trial never commenced.
-