Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00700622
Details
2014-10-16
Interventional
3130 
Insulin Insulin Glargin… Insulin Lispro Insulin, Globin…
Diabetes Mellit… Diabetes, Type …
Sponsor stopped development of the MedTone inhaler in favor of an improved device (Gen2 inhaler)
- Early termination of trial leading to small numbers of subjects analyzed.
NCT01653418
Details
2014-10-15
Interventional
210 
Bortezomib Carmustine Cytarabine Etoposide Melphalan
Multiple Myelom… Neoplasms, Plas…
Due to the high rate of morbidity and mortality
2 early deaths caused a concern for safety and resulted in suspension of enrollment in May 2013. After a review of the data, the investigators determined that this regimen had unexpected toxicity & the trial was closed to enrollment in June 2013.
NCT01455246
2010-019625-34
Details
2014-10-15
Interventional
2/332 
Ceftazidime Daptomycin Meropenem
Ascites Fibrosis Peritonitis Cirrhosis Nosocomial Spon…
Decision of independent monitoring committee after interim analysis: Risk of failure significantly higher in ceftazidime group.
-
NCT00766402
Details
2014-10-15
Interventional
48 
Acetaminophen Diclofenac Tramadol
Spondylarthriti… Spondylitis Spondylitis, An… Pain
-
-
NCT00742339
Details
2014-10-15
Interventional
2/349 
Midodrine Octreotide Terlipressin
Fibrosis Hepatorenal Syn… Liver Cirrhosis Syndrome Cirrhosis
Decision of independent monitoring committee: Risk of non-response to treatment significantly higher in midodrine group than in terlipressin group.
-
NCT01130909
Details
2014-10-13
Interventional
136 
Ketamine
Healthy
The benefit of halting the study to analyze the available data outweighs the benefit of delaying the analysis to include data from remaining treatment periods
-
NCT01015456
Details
2014-10-10
Interventional
359 
Cyclophosphamid… Mycophenolic Ac…
Lupus Nephritis Nephritis
Data Safety Monitoring Board concerning of the participants' safety
-
NCT00571558
Details
2014-10-09
Interventional
115 
Aminolevulinic …
Leukoplakia Leukoplakia, Or… Oral Leukoplaki…
-
-
NCT02115594
Details
2014-10-08
Interventional
20 
Entinostat Fulvestrant
Breast Neoplasm… Breast Cancer
Internal decision
-
NCT00499590
Details
2014-10-06
Interventional
3338 
Ranibizumab
Macular Degener…
-
Study was terminated early.
NCT02254525
Details
2014-10-02
Interventional
3231 
Ibuprofen
Pain, Postopera… Postoperative P…
Sample not reached in traumathology arm
-
NCT01747993
Details
2014-10-02
Interventional
334 
Tamsulosin
Urinary Retenti…
low inclusion
-
NCT02254044
Details
2014-10-01
Interventional
17 
Bivatuzumab mer… Maytansine
Carcinoma Carcinoma, Squa… Squamous Cell C…
-
-
NCT00982696
NCT00905099
Details
2014-09-30
Interventional
25 
Analgesics, Opi… Enkephalins Mitogens Opioid Peptides
Carcinoma, Squa… Head and Neck N… Squamous Cell C… Carcinoma, Squa…
Deemed ineffective
-
NCT01835184
Details
2014-09-25
Interventional
15 
Vemurafenib
Melanoma Recurrent Melan… Stage IIIA Mela… Stage IIIB Mela… Stage IIIC Mela… Stage IV Melano… Unspecified Adu…
-
-
NCT00425438
Details
2014-09-25
Interventional
352 
Azathioprine Cyclophosphamid… Mycophenolic Ac… Prednisolone
Lupus Nephritis Nephritis
Study was terminated early for administrative reasons.
The study was terminated early due to administrative reasons.
NCT00424294
Details
2014-09-25
Interventional
270 
Celecoxib Methotrexate
Arthritis Arthritis, Rheu…
See Detailed Description field
The study was terminated early because it was determined that the dual therapy with CP-195543 and celecoxib had poor tolerability and a high discontinuation rate.
NCT00892242
Details
2014-09-22
Interventional
124 
Zoledronic Acid
Pancreatic Neop… Adenocarcinoma
Principal Investigator decided to close the study early.
-
NCT02245438
Details
2014-09-19
Interventional
152 
Estradiol Ethinyl Estradi… Norethindrone Norethindrone A… Norinyl Ritonavir Tipranavir
Healthy
-
-
NCT00198159
Details
2014-09-19
Interventional
2-
Gefitinib
Neoplasms, Germ… Refractory Germ…
-
-