Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00427934
Details
2014-11-05
Interventional
2128 
Maraviroc
Arthritis Arthritis, Rheu…
See Detailed Description.
-
NCT01172756
2010-018436-41
Details
2014-11-04
Interventional
239 
Riociguat
Hypertension Hypertension, P… Ventricular Dys… Ventricular Dys…
Recruitment was only stopped after the statistical power of the study was reached and the study objectives could be met despite the premature discontinuation.
-
NCT00753220
Details
2014-11-04
Interventional
1/27 
Cyclophosphamid…
Prostatic Neopl… Prostate Cancer
Withdrew the IND with the FDA.
-
NCT00300885
2005-005245-19
Details
2014-11-04
Interventional
3
[1 Refs]
926 
Albumin-Bound P… Carboplatin Paclitaxel Sorafenib
Carcinoma, Non-… Lung Neoplasms Carcinoma, Non-…
Based on the results of the interim analysis, it was determined that the study would not meet its primary efficacy endpoint and the study was terminated early.
Based on the results of the interim analysis, it was determined that the study would not meet its primary efficacy endpoint and the study was terminated early. The planned biomarker analysis was suspended due to early termination.
NCT01853176
Details
2014-11-02
Interventional
44 
Bupivacaine
Pain, Postopera…
required documentation too onerous
Trial terminated prior to any meaningful patient accrual so no analysis performed.
NCT01227512
Details
2014-10-30
Interventional
3124 
Tolvaptan
Hyponatremia Inappropriate A… Dilutional Hypo…
Recruitment challenges and results of interim futility analysis, which showed less than likely to achieve primary endpoint goal-length of hospital stay.
-
NCT01196104
Details
2014-10-30
Interventional
339 
Insulin Insulin Aspart Insulin Glargin… Insulin, Globin…
Diabetes Mellit… Type 2 Diabetes
For Business Reasons
- Early termination of trial leading to small numbers of subjects analyzed.
NCT00747006
Details
2014-10-30
Interventional
218 
Insulin Lispro
Diabetes Mellit… Diabetes Mellit… Diabetes Mellit… Respiratory Asp…
Business reasons
- Early termination of trial leading to small numbers of subjects analyzed.
NCT00918385
Details
2014-10-29
Interventional
257 
Dasatinib Nilutamide
Prostatic Neopl… Prostate Cancer
Permanent closure of trial to further accrual based on IDE disapproval
-
NCT00446589
Details
2014-10-29
Interventional
419 
Ibandronic Acid Teriparatide
Osteoporosis
due to financial problems
-
NCT00446329
Details
2014-10-29
Interventional
415 
Cinacalcet
Hyperparathyroi… Hyperparathyroi… Neoplasm Metast… Secondary Hyper…
due to financial problems
-
NCT00535262
Details
2014-10-28
Interventional
43 
Selegiline
Bipolar Disorde… Depression Depressive Diso… Bipolar Depress…
Current lack of medication support.
Early termination due to lack of financial support; only 3 participants were entered into the study; no data was analyzed.
NCT01313663
Details
2014-10-27
Interventional
220 
Pemetrexed
Carcinoma, Non-… Lung Neoplasms Small Cell Lung… Lung Cancer, Sm…
-
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NCT00619229
2005-005686-11
Details
2014-10-27
Interventional
337 
Alprostadil
Macular Degener…
Interim Analysis: Optimization of study design required.
-
NCT02273544
Details
2014-10-24
Interventional
116 
Aspirin, Dipyri…
Healthy
-
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NCT01848106
2013-001384-23
Details
2014-10-23
Interventional
33232 
Bivalirudin
Coronary Artery… Coronary Diseas… Myocardial Isch…
Clinical Hold
-
NCT00548717
Details
2014-10-21
Interventional
215 
Bortezomib Mycophenolic Ac… Sirolimus
Graft vs Host D… Graft-vs-Host D…
First two patients enrolled after trial reopened, developed grade III-IV acute GVHD and subsequently passed away.
Early termination leading to small numbers of subjects analyzed. Results are reported for transparency only, and should not be used to extrapolate significant conclusions.
NCT00881504
Details
2014-10-20
Interventional
29 
Bevacizumab
Biliary Tract N… Biliary Tract C…
It was not possible to get insurance companies to cover bevacizumab.
-
NCT01342016
Details
2014-10-17
Interventional
384 
Leflunomide Prednisone Tacrolimus
Lupus Nephritis Nephritis
Due to safety concern of active control drug
-
NCT00682656
Details
2014-10-17
Interventional
2/348 
Azithromycin Meglumine Antim…
Leishmaniasis Leishmaniasis, … Cutaneous Leish…
Efficacy issues on test arm
-