Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01283100
Details
2014-12-24
Interventional
10 
Dolutegravir
Acquired Immuno… HIV Infections Infection, Huma…
In a Phase II study in HIV-infected patients there were a number of seizures, although exact causality could not be assessed phase 1 activity was terminated.
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NCT01072136
Details
2014-12-24
Interventional
387 
Azithromycin Cefixime
Uterine Cervici… Vaginitis Vaginosis, Bact… Cervicitis Vaginitis Bacte…
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The study closed early due to slow accrual with 11% of the targeted sample size enrolled. Therefore, precision and power were low.
NCT00845832
2008-005525-11
Details
2014-12-24
Interventional
224 
Rituximab
Arthritis Arthritis, Rheu… Rheumatoid Arth…
The study was terminated early because of a related decision to stop the development of ocrelizumab in rheumatoid arthritis.
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NCT01573286
Details
2014-12-23
Interventional
1/2
[1 Refs]
13 
Glucagon Glucagon-Like P…
Intestinal Fail… Short Bowel Syn…
GLP-2 Drug product stability concerns
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NCT01378481
Details
2014-12-23
Interventional
130 
Vorinostat
Astrocytoma Brain Neoplasms Glioblastoma Glioma Gliosarcoma Oligodendroglio… Recurrence Adult Anaplasti… Adult Anaplasti… Adult Giant Cel… Adult Glioblast… Adult Gliosarco… Adult Mixed Gli… Recurrent Adult…
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NCT01035216
Details
2014-12-23
Interventional
118 
CPG-oligonucleo…
Leukemia Leukemia, Lymph… Leukemia, Lymph…
This study has been terminated.
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NCT00072137
Details
2014-12-23
Interventional
121 
Adjuvants, Vacc… Metronidazole Molgramostim Sargramostim Vaccines
Carcinoma Urinary Bladder… Bladder Adenoca… Bladder Squamou… Bladder Urothel… Recurrent Bladd… Stage I Bladder… Stage II Bladde… Stage III Bladd… Stage IV Bladde…
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NCT00009906
Details
2014-12-23
Interventional
3748 
Imatinib Mesyla…
Gastrointestina… Gastrointestina…
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NCT01812239
Details
2014-12-19
Interventional
2/30 
Progesterone Progestins
Premature Birth
inability to retain study drug with comparable placebo.
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NCT01494350
Details
2014-12-19
Interventional
250 
Gentamicins Paromomycin
Leishmaniasis Leishmaniasis, … Cutaneous Leish…
This study was closed prematurely due study team travel restrictions.
This study was closed prematurely due study team and travel restrictions but not due to any safety issues with the study subjects. Only a total of 50 of the 110 planned subjects were enrolled in the study.
NCT01266005
Details
2014-12-18
Interventional
4-
Clevudine Entecavir
Hepatitis Hepatitis B Hepatitis B, Ch… Hepatitis, Chro… Chronic Hepatit…
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NCT01264133
Details
2014-12-18
Interventional
4-
Adefovir Clevudine
Hepatitis Hepatitis A Hepatitis B Hepatitis B, Ch… Hepatitis, Chro… Chronic Hepatit…
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NCT01014364
Details
2014-12-18
Interventional
3
[1 Refs]
40 
Hydrocortisone Hydrocortisone … Hydrocortisone … Hydrocortisone …
Influenza, Huma… Pneumonia Pneumonia, Vira… Influenza in Hu…
the H1N1 pandemic is now over, and fewer cases than expected were observed
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NCT00649584
Details
2014-12-18
Interventional
1
[1 Refs]
44 
Brentuximab Ved… Gemcitabine
Hodgkin Disease Lymphoma Lymphoma, Large… Lymphoma, Non-H… Disease, Hodgki…
Sponsor decision not to enroll cohorts of combined SGN-35 and gemcitabine therapy.
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NCT00622479
Details
2014-12-18
Interventional
112 
Sorafenib
Carcinoma Carcinoma, Rena… Hypophosphatemi…
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NCT00621673
Details
2014-12-18
Interventional
41 
Factor VIII
Hemophilia A
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NCT01969006
Details
2014-12-17
Interventional
20 
Bupivacaine
Pain, Postopera… Post Operative …
Another study has been planned, so we did not initiate this one.
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NCT00887276
2005-000771-18
Details
2014-12-17
Interventional
4290 
Amoxicillin Ampicillin Moxifloxacin
Pneumonia Community Acqui…
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NCT00354523
Details
2014-12-17
Interventional
1/221 
Capecitabine Dacarbazine Imatinib Mesyla…
Carcinoma Thyroid Disease… Thyroid Neoplas… Solid Tumor Thyroid Cancer
Study closed following Phase I portion, insufficient activity to continue to Phase II.
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NCT00306150
2005-004055-35
Details
2014-12-17
Interventional
357 
Aprotinin
Blood Loss, Sur… Hemorrhage Postoperative H…
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