Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00787644
Details
2015-02-26
Interventional
228 
Pioglitazone
Asthma Obesity
new safety concerns which emerged about pioglitazone during the trial
Early termination leading to small numbers of subjects analyzed
NCT02113891
Details
2015-02-25
Interventional
1/20 
Eculizumab
Subclinical Acu…
disengagement of the sponsor Alexion Pharmaceuticals
-
NCT00934739
Details
2015-02-25
Interventional
2/3150 
Celecoxib Cyclophosphamid… Dexamethasone Thalidomide
Mouth Neoplasms Oral Cavity Can…
-
-
NCT00529503
Details
2015-02-25
Interventional
2
[1 Refs]
151 
Carboplatin Dacetuzumab Etoposide Ifosfamide Rituximab
Lymphoma Lymphoma, Large… Lymphoma, Non-H…
-
-
NCT00376428
Details
2015-02-25
Interventional
2-
Gentamicins
Cystic Fibrosis Fibrosis
-
-
NCT01995058
Details
2015-02-20
Interventional
254 
Abiraterone Ace… Prednisone
Prostatic Neopl… Castration Resi… Prostate Cancer
Study stopped after results of cabozantinib Phase 3 CRPC study XL184-307.
-
NCT00816166
Details
2015-02-20
Interventional
2/3125 
Aspirin Clopidogrel
Ischemia Ischemic Attack… Ischemic Stroke Transient Ische…
-
Early termination of enrollment led to small numbers of subjects analyzed (less than 50% of the prospectively planned sample size). Various endpoints, subgroup and sensitivity analyses were not conducted because the study was not fully enrolled.
NCT00375596
Details
2015-02-20
Interventional
20 
Ketotifen Vasoconstrictor…
Conjunctivitis Conjunctivitis,… Allergic Conjun…
Study withdrawn without starting or enrolling subjects due to a business decision to not proceed with the project.
-
NCT00767000
Details
2015-02-19
Interventional
2
[1 Refs]
813 
Insulin Glargin… Metformin
Diabetes Mellit… Diabetes Mellit…
-
-
NCT02246816
Details
2015-02-18
Interventional
30 
Opium
Short Bowel Syn… Syndrome SBS Short Gut Short Gut Syndr…
Transfer of IND to different marketing authorization representative.
-
NCT02242656
Details
2015-02-18
Interventional
30 
Opium
Short Bowel Syn… Syndrome SBS Short Bowel Short Gut Short Gut Syndr…
Transfer of IND to new marketing authorization holder
-
NCT01013831
Details
2015-02-18
Interventional
160 
Erlotinib Hydro…
Metaplasia Precancerous Co… Dysplasia Pulmonary Preca…
-
-
NCT00960934
2009-012926-35
Details
2015-02-18
Interventional
2
[1 Refs]
383 
Calcium Calcium Carbona… Cholecalciferol Vitamin D
Osteoporosis
-
-
NCT01592773
Details
2015-02-16
Interventional
2747 
Memantine
Asperger Syndro… Autism Spectrum… Autistic Disord… Child Developme… Developmental D… Asperger's Asperger's Diso… Autism Autism Spectrum… Pediatric Autis… Pervasive Devel…
Terminated because primary efficacy parameter failed to demonstrate statistically significant difference between memantine and placebo in controlled trials
-
NCT00513253
Details
2015-02-16
Interventional
10 
Lapatinib
Healthy Subject…
It was determined not to be needed based on the clinical development plan of Tykerb.
-
NCT01111448
Details
2015-02-13
Interventional
220 
MTOR Inhibitors Sirolimus Temsirolimus
Myelodysplastic… Preleukemia Syndrome Myelodysplastic…
Unfavourable Risk-Benefit-Ratio
-
NCT00430742
Details
2015-02-13
Interventional
3
[1 Refs]
600 
N-(3-(4-chlorop…
Diabetes Mellit… Diabetes Mellit… Obesity Type 2 … Type 2 Diabetes…
The overall profile does not support development for obesity
-
NCT00363883
Details
2015-02-13
Interventional
214 
Vorinostat
Carcinoma Carcinoma, Tran… Kidney Neoplasm… Recurrence Ureteral Neopla… Urinary Bladder… Localized Trans… Metastatic Tran… Recurrent Trans… Regional Transi… Transitional Ce…
Trial stopped early for futility
Study was terminated early after the first stage of a two-stage design, allowing for early termination for discouraging results.
NCT00958776
Details
2015-02-12
Interventional
3405 
Peramivir
Headache Influenza, Huma… Pharyngitis Cough Fever Nasal Congestio… Seasonal Influe… Sore Throat
This study was terminated for futility
Interim analysis of the primary efficacy endpoint (time to clinical resolution) performed after the end of the 2012 Southern Hemisphere influenza season lead to study termination for futility. Final enrollment was ~70% of the planned enrollment.
NCT02218762
Details
2015-02-11
Interventional
10 
Fluticasone Fluticasone-Sal… Salmeterol Xina… Xhance
Asthma
It was decided that data from this study are no longer required and therefore it is not necessary to expose patients to the study medication
-