Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00430040
Details
2024-04-16
Interventional
414 
Carvedilol Lisinopril
Diabetes Mellit… Diabetes Mellit… Hypertension
-
-
NCT05338580
Details
2024-04-15
Interventional
20 
Pembrolizumab
Carcinoma Carcinoma, Tran… First-line Non-… First-line Urot… Second-line Mel… Second-line Uro…
Company Development strategy adjustment
-
NCT04751370
Details
2024-04-15
Interventional
2-
Ipilimumab Nivolumab
Adenocarcinoma Rectal Neoplasm… Locally Advance… Stage II Rectal… Stage III Recta…
Scheduled Interim Monitoring
-
NCT06061523
Details
2024-04-12
Interventional
10 
Sotorasib
Healthy Partici…
FDA and EMA agreed existing data are appropriate for approval and no further BE studies are required.
-
NCT06046482
Details
2024-04-12
Interventional
2-
Cetuximab Docetaxel Magrolimab Pembrolizumab
Carcinoma Carcinoma, Squa… Squamous Cell C… Head Neck
PI Request
-
NCT05712278
Details
2024-04-12
Interventional
17 
Cytarabine Fludarabine
Leukemia Leukemia, Myelo… Leukemia, Myelo… Acute Myeloid L…
Sponsor's decision
-
NCT05441930
Details
2024-04-12
Interventional
10 
Levofloxacin
Cataract
Sponsor has suspended study to conserve capital for clinical development of lead asset
-
NCT05429762
2022-001213-39
Details
2024-04-12
Interventional
156 
Maytansine
Neoplasm
Tusamitamab ravtansine clinical development program is discontinued as CARMEN-LC03 trial did not meet dual primary endpoint of improving progression-free survival. The decision is not related to any safety concern.
-
NCT04806178
Details
2024-04-12
Interventional
330 
BCG Vaccine
Urinary Bladder… Bacillus Calmet… Bladder Cancer
Recruitment delay
-
NCT05501665
Details
2024-04-11
Interventional
1/2-
Albumin-Bound P… Atezolizumab Carboplatin Cemiplimab Deoxyglucose Fluorodeoxygluc… Ipilimumab Nivolumab Paclitaxel Pembrolizumab Pemetrexed
Carcinoma, Non-… Lung Neoplasms Lung Non-Small … Stage III Lung … Stage IV Lung C…
Pending a protocol amendment
-
NCT05367401
2021-003263-10
Details
2024-04-11
Interventional
1/20 
Azacitidine Magrolimab
Leukemia Leukemia, Myelo… Leukemia, Myelo… Myelodysplastic… Preleukemia Syndrome Acute Myeloid L…
waiting for update from Study Lead
-
NCT04996004
Details
2024-04-11
Interventional
275 
Doxorubicin
Leiomyosarcoma
Pfizer decided to terminate the study for administrative reasons. The termination was neither due to safety concerns nor a request from the regulatory authorities.
-
NCT04677855
Details
2024-04-10
Interventional
17 
Dutasteride Prednisone
Prostatic Neopl… Prostate Cancer
Business Decision due to insufficient enrollment
-
NCT04232306
Details
2024-04-10
Interventional
40 
Bupivacaine
Pain, Postopera… Cesarean Sectio… Postoperative P…
Lack of resources to continue.
-
NCT04057365
Details
2024-04-10
Interventional
215 
Nivolumab
Biliary Tract N… Biliary Tract C…
Based on a Simon 2-stage design, this study did not meet response criteria to proceed to stage 2.
-
NCT06068153
Details
2024-04-09
Interventional
20 
Lenvatinib Sotorasib
Carcinoma, Non-… KRAS G12C Metastatic Non …
In view of the recent developments in the field (the increasing number of trials with new KRAS inhibitors), the window of opportunity to answer the question raised in the AMBER trial was missed.
-
NCT05900674
Details
2024-04-09
Interventional
20 
Reteplase
Ischemic Stroke Stroke
Sponsor
-
NCT05554341
Details
2024-04-09
Interventional
2-
Albumin-Bound P… Nilotinib Paclitaxel
Neoplasms Metastatic Mali… Refractory Mali…
Scheduled Interim Monitoring
-
NCT04970719
Details
2024-04-09
Interventional
3
[16 Refs]
0 
Dexamethasone Janus Kinase In… Remdesivir
COVID-19 Diabetes Mellit… COVID-19 Pneumo…
adequate cases were not available
-
NCT04594811
2020-004175-41
Details
2024-04-09
Interventional
110 
Nivolumab
Adenocarcinoma Esophageal Neop… Gastric or Gast…
Company strategic decision
-