Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

Filter:

Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
Free Text
Annotations

7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00720512
2007-002886-11
Details
2015-03-11
Interventional
3184 
Bevacizumab Calcium Fluorouracil Irinotecan Leucovorin Levoleucovorin Oxaliplatin
Colorectal Neop… Colorectal Canc…
-
-
NCT00290082
Details
2015-03-11
Interventional
3-
Loxapine Midazolam
Psychomotor Agi… Acute Agitated …
2 complications with midazolam
-
NCT00735345
2008-001016-21
Details
2015-03-09
Interventional
2-
Cetuximab Docetaxel
Esophageal Neop… Esophageal Canc…
because of safety concerns the study was terminated prematurely
-
NCT00939328
Details
2015-03-06
Interventional
20 
Bendamustine Hy… Rituximab
Leukemia Leukemia, Lymph… Leukemia, Lymph…
question was no longer committee priority
-
NCT00788580
Details
2015-03-06
Interventional
10 
MTOR Inhibitors Sirolimus Temsirolimus
Neoplasms Unspecified Adu…
Study was discontinued.
-
NCT00684164
Details
2015-03-06
Interventional
30 
Conivaptan
Hyponatremia
Unable to complete a contract with the Sponsor
-
NCT00251589
Details
2015-03-06
Interventional
1/223 
Erlotinib Hydro… Vorinostat
Carcinoma, Non-… Lung Neoplasms
This trial is being closed based on lack of substantive efficacy, slow accrual and overall tolerance in patients treated to date.
Due to the slow pace of patient accrual, failure to observe meaningful efficacy in treated patients, and overall intolerance of the combination regimen, the study was terminated prematurely on 12-Oct-2007.
NCT01518933
Details
2015-03-05
Interventional
220 
Silybin Silymarin
Hepatitis Hepatitis A Hepatitis C Recurrence Hepatitis C Vir…
when a blind review highlighted that at least 43% of patients had a virological response
-
NCT01324115
2009-013621-42
Details
2015-03-05
Interventional
16 
Nitroarginine
Neoplasms Unspecified Adu…
Sponsor Decision
-
NCT01184911
Details
2015-03-05
Interventional
40 
Fanasil, pyrime… Pyrimethamine Sulfadoxine
Malaria Intermittent Pr… Placental Malar…
Research plan changed; no longer conducting clinical trial.
-
NCT00740545
Details
2015-03-05
Interventional
3258 
Enoxaparin
Alive and Viabl…
Stopped for futility
-
NCT00051701
Details
2015-03-05
Interventional
1/2-
Alemtuzumab
Lymphoma Lymphoma, Non-H… Non-Hodgkins Ly…
-
-
NCT02378415
Details
2015-03-04
Interventional
120 
Ketamine
Depression Depressive Diso… Acute Depressio…
Discrepancies in medication orders
-
NCT01509053
Details
2015-03-04
Interventional
330 
Aripiprazole
Schizophrenia
-
-
NCT00575978
Details
2015-03-04
Interventional
1/20 
Hydralazine
Breast Neoplasm… Breast Cancer
IRB request
-
NCT00160563
Details
2015-03-03
Interventional
3207 
Levocetirizine
Asthma
The predecessor study A00309 (NCT00152464) did not show statistical significance in time to onset of asthma between the levocetirizine and placebo groups.
-
NCT00325455
Details
2015-03-02
Interventional
2
[1 Refs]
500 
Anacetrapib
Hypercholestero… Hyperlipidemias Hyperlipoprotei… Mixed Hyperlipe…
-
-
NCT00072189
Details
2015-03-02
Interventional
217 
7-hydroxystauro…
Melanoma Recurrent Melan… Stage IV Melano…
Early termination for discouraging results
Study was terminated early after the first stage of a two-stage design, allowing for early termination for discouraging results
NCT01299922
Details
2015-02-27
Interventional
30 
Cyclosporine Cyclosporins Mycophenolic Ac…
Lupus Nephritis Nephritis
IT was impossible to find patients
-
NCT00445263
Details
2015-02-27
Interventional
4170 
Tirofiban
Acute Coronary … Coronary Artery… Coronary Diseas… CORONARY DISEAS…
Because of inclusion delay
-