Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01091870
Details
2015-03-25
Interventional
20 
Citric Acid Sildenafil Citr… Sodium Citrate
Aneurysm Hemorrhage Intracranial An… Rupture Subarachnoid He… Vasospasm, Intr… Cerebral Vasosp… Rupture of Intr…
Absence of inclusion criteria
-
NCT00779220
Details
2015-03-25
Interventional
2152 
Methotrexate Ocrelizumab
Arthritis Arthritis, Rheu… Rheumatoid Arth…
-
-
NCT00031135
Details
2015-03-25
Interventional
2-
Choline
Liver Diseases
-
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NCT00030056
Details
2015-03-25
Interventional
2-
Molgramostim Sargramostim
Pulmonary Alveo…
-
-
NCT01175330
Details
2015-03-24
Interventional
3
[1 Refs]
39 
Soybean oil, ph…
Atrial Fibrilla… Coronary Artery… Heart Diseases Myocardial Isch… Ischemic Heart …
Interim analysis did not reveal of anticipated benefits of intervention
-
NCT01118871
Details
2015-03-24
Interventional
43 
Darunavir Emtricitabine, … Etravirine Ritonavir
HIV Infections HIV
-
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NCT00833768
2007-003885-16
Details
2015-03-24
Interventional
35 
Sevelamer
Hyperphosphatem… Kidney Diseases Renal Insuffici… Chronic Kidney …
After an extensive review,the ASPIRE in CKD study was terminated because it was not possible to complete the study in an appropriate time frame.
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NCT00796666
Details
2015-03-24
Interventional
3131 
Sildenafil Citr… Sitaxsentan
Familial Primar… Hypertension Hypertension, P… Pulmonary Arter… Pulmonary Hyper…
Safety Issue: The trial was prematurely terminated on Dec 9, 2010, due to safety concerns, specifically new emerging evidence of hepatic injury.
Study terminated early by sponsor, no Week 48 information collected.
NCT00795639
Details
2015-03-24
Interventional
3183 
Sitaxsentan
Familial Primar… Hypertension Hypertension, P… Pulmonary Arter… Pulmonary Hyper…
Safety Issue: The trial was prematurely terminated on Dec 9, 2010, due to safety concerns, specifically new emerging evidence of hepatic injury.
Study terminated early.
NCT00738985
Details
2015-03-24
Interventional
40 
Ezetimibe Ezetimibe, Simv… Simvastatin
Cardiovascular … Hyperlipidemia,… Hyperlipidemias Hyperlipoprotei… Hyperlipidemia
The study was cancelled due to budget limitations
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NCT00213577
Details
2015-03-24
Interventional
280 
Botulinum Toxin…
Urinary Bladder… Overactive Blad…
the study has concluded normally;
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NCT00430677
Details
2015-03-20
Interventional
2/3423 
Abatacept Mycophenolic Ac… Prednisolone Prednisone
Lupus Erythemat… Systemic Lupus …
Terminated due to failure to meet the primary efficacy endpoint in the Short-term Period
-
NCT00031577
Details
2015-03-19
Interventional
111 
Paclitaxel
Central Nervous… Glioma Nervous System … Brain and Centr…
Administrative closure 9/22/2006. Decline in enrollment at CHOP. due to competing protocols with new agents.
-
NCT02028312
Details
2015-03-18
Interventional
40 
Loteprednol Eta… Lubricant Eye D…
Dry Eye Syndrom… Eye Diseases Keratoconjuncti… Dry Eye Disease
Per Sponsor
-
NCT00068770
Details
2015-03-18
Interventional
235 
Celecoxib
Central Nervous… Nervous System … Brain and Centr…
EORTC trail showed TMZ & RT conferred significant survivial in this population
Study ended early when results from another study became available documenting Temozolomide (TMZ) and radiation improved survival, we felt it was unethical to continue this study, our study did not include TMZ.
NCT01467479
Details
2015-03-17
Interventional
3185 
Anti-Retroviral… Interferon alph… Interferon-alph… Interferons Peginterferon a… Ribavirin
Hepatitis Hepatitis A Hepatitis C
It was decided by Sponsor on 13 January 2014 to terminate study early at primary efficacy endpoint as part of a decision to modify drug development plan.
It was decided by Sponsor on 13 January 2014 to terminate the study early at the primary efficacy endpoint (SVR12) as part of a decision to modify the drug development plan. Eligible participants completed virologic follow-up after termination.
NCT01157546
Details
2015-03-17
Interventional
125 
Lidocaine
Vomiting Assessment of R… Incidence of Na… Opioid Consumpt… Postoperative P…
Low recruitment rate. In our center, open radical prostatectomies have been almost completely replaced by robotic prostatectomies.
-
NCT01130701
Details
2015-03-17
Interventional
2
[4 Refs]
0 
Capecitabine Panitumumab
Pancreatic Neop… Pancreatic Canc…
Study never went beyond FDA application for an IND #. FDAA required institutional DSMC which this institution then lacked.
-
NCT00729365
Details
2015-03-17
Interventional
365 
Angiotensin-Con… Ramipril
Diabetes Mellit… Diabetes Mellit… Type 1 Diabetes
Data from other studies showed that study could not be completef successfully
The study was terminated prematurely because of new information from the literature from other studies showing that this study could not be successful. Only 59 patients were screened and consented and 46 were found acceptable who were randomized.
NCT00384605
Details
2015-03-13
Interventional
31000 
N-(3-(4-chlorop…
Obesity Overweight
The overall profile does not support development for obesity
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