Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

Filter:

Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
Free Text
Annotations

7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01375816
2010-020468-39
Details
2015-06-04
Interventional
255 
Bevacizumab Calcium Fluorouracil Irinotecan Leucovorin Levoleucovorin
Colorectal Neop… Colorectal Canc…
efficacy interim analysis as per protocol
-
NCT00830401
Details
2015-06-04
Interventional
2700 
Doxycycline
Congenital Abno… Minor Intra-ute…
Abnormality prevalence revealed to be much lower than expected.
-
NCT00781755
Details
2015-06-04
Interventional
40 
Varenicline
Tobacco Use Dis…
Study design was altered such that a treatment component was removed through the VA IRB. We did not and will not begin this clinical trial.
-
NCT00663455
Details
2015-06-04
Interventional
450 
Cyclosporine Cyclosporins
Kidney Transpla…
Recruitment goals were not achieved. Extension of the trial concept had to be abjected due to methodological reasons.
-
NCT00044837
Details
2015-06-04
Interventional
1-
Estradiol Medroxyprogeste… Medroxyprogeste…
HIV Infections
-
-
NCT00500240
Details
2015-06-03
Interventional
352 
Insulin Insulin Aspart Insulin Glargin… Insulin, Globin…
Leukemia Leukemia, Lymph… Lymphoma Precursor Cell …
Terminated early due to futility.
Study terminated early due to futility at the pre-determined interim analysis point.
NCT00303433
NCT00303095
Details
2015-06-03
Interventional
4-
Memantine
Delirium Emergence Delir… Post-Operative …
-
-
NCT00245791
Details
2015-06-03
Interventional
4-
Levofloxacin
Communicable Di… Infections Urinary Tract I… Complicated Uri…
-
-
NCT00202891
Details
2015-06-03
Interventional
40 
Sisomicin
Pyoderma
No further local interest in pursuing the study.
-
NCT01846026
2009-015649-21
Details
2015-06-02
Interventional
1/20 
Cholecalciferol Vitamin D
Colitis Colitis, Ulcera… Ulcer Ulcerative Coli…
At the planned study start new treatment guidelines for this disease with new drugs were implemented in clinical practice.
-
NCT01030120
Details
2015-06-02
Interventional
2/30 
Etanercept
Chronic Urticar… Urticaria Chronic Idiopat…
Unable to complete agreement with sponsor
-
NCT01841684
2012-002434-37
Details
2015-06-01
Interventional
32 
Anacetrapib
Homozygous Fami… Hypercholestero… Hyperlipidemias Hyperlipoprotei… Hyperlipoprotei…
-
-
NCT00221494
Details
2015-06-01
Interventional
40 
Citalopram Pindolol
Depression Depressive Diso…
PI move
-
NCT01446211
2011-001219-30
Details
2015-05-29
Interventional
34 
Azathioprine Cyclophosphamid… Glucocorticoids Gusperimus Methotrexate
Granulomatosis … Wegeners Granul…
Change of design consideration
-
NCT00780455
2006-006673-24
Details
2015-05-29
Interventional
44 
Interferon beta… Interferon-beta Interferons
Multiple Sclero… Multiple Sclero…
-
Due to the very low number of patients enrolled in the study, no statistical report was done. Study was early terminated.
NCT00695318
Details
2015-05-29
Interventional
217 
Fluocinolone Ac…
Atrophy Geographic Atro… Macular Degener… Age-Related Mac…
-
-
NCT00694200
Details
2015-05-29
Interventional
213 
Bevacizumab Vinorelbine
Breast Neoplasm… Breast Cancer
Not reached the statistical hypothesis at the interim analysis
-
NCT00690118
2006-005410-13
Details
2015-05-29
Interventional
2219 
Pioglitazone
Amyotrophic Lat… Motor Neuron Di… Sclerosis
The interim analysis showed no tendency in favour of the verum group. Therefore it was decided to stop the study prematurely.
-
NCT00555217
Details
2015-05-29
Interventional
3
[4 Refs]
1448 
Lisinopril Losartan
Diabetes Mellit… Kidney Diseases Kidney Disease Nephropathy Type 2 Diabetes
It was stopped primarily because of safety concerns along with low conditional power to detect a treatment effect on the primary outcome.
In October, 2012 the DMC recommended that study treatment be stopped primarily because of safety concerns along with low conditional power to detect a treatment effect on the primary outcome.
NCT02218775
Details
2015-05-28
Interventional
10 
Aticaprant
Anxiety Disorde…
Funding for the study ended with one subject consented, but not randomized
-