Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01525225
Details
2015-06-22
Interventional
14 
Metformin Saxagliptin
Diabetes Mellit… Diabetes Mellit… Type 2 Diabetes…
Release of Post Marketing Requirement for this study. Terminated November 2013.
Due to the small number of participants (2), the primary endpoints, pharmacokinetic parameters, were not calculated.
NCT01222143
Details
2015-06-22
Interventional
1/212 
Nilotinib
Leukemia Leukemia, Myelo… Leukemia, Myelo… Acute Myeloid L…
-
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NCT02429882
2014-003701-15
Details
2015-06-19
Interventional
20 
Brodalumab
Axial Spondyloa… Spondylarthriti… Spondylitis
Per Amgen's decision to discontinue co-development and co-commercialization of brodalumab, study is being cancelled/closed.
-
NCT02083276
2013-002379-17
Details
2015-06-19
Interventional
220 
Amdinocillin Pi…
Chlamydia Infec… Communicable Di… Infections Urethritis Chlamydia Trach… Chlamydial Uret…
Treatment failure on study medication observed
-
NCT01655212
2011-005378-44
Details
2015-06-18
Interventional
32 
Valganciclovir
Cytomegalovirus… Deafness Hearing Loss Hearing Loss, S… Congenital Cyto… Sensorineural H…
1 Indication for further investigations (brain ultrasound). 2 Change of study design to efficacy study with historical control group.
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NCT01467505
Details
2015-06-18
Interventional
261 
Immunosuppressi… Interferon alph… Interferon-alph… Interferons Peginterferon a… Ribavirin
Hepatitis Hepatitis C
The study was terminated early by the sponsor on 13 January 2014 due to a decision to modify the drug development plan.
It was decided by Sponsor on 13 January 2014 to terminate the study early at the primary efficacy endpoint (SVR12) as part of a decision to modify the drug development plan. Eligible participants completed virologic follow-up after termination.
NCT01356992
Details
2015-06-18
Interventional
362 
Enoxaparin
Acute Coronary … Angina, Unstabl… Infarction Myocardial Infa… Non ST Segment … Unstable Angina
Change in strategy regarding the product by the company
-
NCT02240602
Details
2015-06-16
Interventional
30 
Oxycodone
Pain, Postopera… Pain
Lack of internal resources
-
NCT00703690
Details
2015-06-12
Interventional
2436 
Fenofibrate
Dyslipidemias Metabolic Syndr… Syndrome Metabolic X Syn…
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-
NCT00543361
Details
2015-06-12
Interventional
3382 
Metformin
Diabetes Mellit…
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NCT00396487
2006-002957-56
Details
2015-06-11
Interventional
31 
Capecitabine Fluorouracil Irinotecan
Colorectal Neop… Metastatic Colo…
Only one patient included as per Feb. 4, 2008.
-
NCT01720056
Details
2015-06-10
Interventional
414 
Triamcinolone A… Verapamil
Keloid Recurrence Keloid Scars
Objective of study achieved after interim analysis.
-
NCT01459913
Details
2015-06-10
Interventional
3239 
Interferon alph… Interferon-alph… Interferons Peginterferon a… Ribavirin
Hepatitis Hepatitis C Hepatitis C, Ch…
The study was terminated early by the sponsor on 13 January 2014 due to a decision to modify the drug development plan.
The study was terminated early at the primary efficacy endpoint (SVR12), by the sponsor on 13 January 2014 due to a decision to modify the drug development plan.
NCT00875875
Details
2015-06-10
Interventional
40 
Rifaximin
Diarrhea Dysentery Travelers' Diar…
No study population in Mexico (H1N1). Study withdrawn from IRB consideration.
-
NCT00718809
Details
2015-06-10
Interventional
221 
Saracatinib
Carcinoma Thymoma Thymus Neoplasm… Invasive Thymom… Recurrent Thymo… Stage III Thymo… Stage IVA Thymo… Stage IVB Thymo…
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NCT02120118
Details
2015-06-09
Interventional
20 
Docetaxel
Hyperthermia Solid Tumors
Taiwan FDA asked for seperating this protocol into one disease site per protocol.
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NCT01080248
Details
2015-06-09
Interventional
22 
Gemcitabine
Pancreatic Neop… Pancreatic Canc…
Closed due to delay by GSK
-
NCT00800150
Details
2015-06-08
Interventional
16 
Fludarabine Fludarabine pho… Melphalan
Leukemia Lymphoma Multiple Myelom… Myelodysplastic… Myelodysplastic… Myeloproliferat… Neoplasms Neoplasms, Plas… Plasmacytoma Preleukemia Syndrome Chronic Myelopr… Multiple Myelom… Myelodysplastic…
Protocol objective could not be met. A new study with amended eligibility criteria will be developed.
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NCT00019864
NCT00001821
Details
2015-06-08
Interventional
2-
Calcium Dexrazoxane Doxorubicin Leucovorin Levoleucovorin Liposomal doxor… Methotrexate Razoxane
Cardiotoxicity Osteosarcoma Cardiac Toxicit… Sarcoma
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NCT00005777
Details
2015-06-08
Interventional
3
[2 Refs]
220 
Dexamethasone
Birth Weight Bronchopulmonar… Lung Diseases Premature Birth Respiratory Dis… Respiratory Dis… Infant, Low Bir… Infant, Newborn Infant, Prematu… Infant, Small f…
The trial was halted because of unanticipated nonrespiratory adverse events related to dexamethasone therapy.
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