Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

Filter:

Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
Free Text
Annotations

7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00540995
Details
2023-11-30
Interventional
1/225 
Busulfan Etoposide Etoposide phosp… Podophyllotoxin
Anemia, Refract… Anemia, Refract… Blast Crisis Leukemia Leukemia, Myelo… Leukemia, Myelo… Leukemia, Myelo… Myelodysplastic… Preleukemia Recurrence Syndrome Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Adult Acute Mye… Blastic Phase C… Childhood Acute… Childhood Chron… Childhood Myelo… Previously Trea… Recurrent Adult… Recurrent Child… Refractory Anem…
Unable to safely escalate to TMLI doses that were hypothesized to be effective and less toxic than FTBI. Likely due to the giving of Busulfan prior to radiation delivery. Therefore, the study was abandoned and no further patients were accrued.
-
NCT05644626
Details
2023-11-29
Interventional
10 
Tislelizumab
Neoplasms Solid Tumors
Sponsor determined the data was no longer needed.
-
NCT04007367
2019-002640-25
Details
2023-11-29
Interventional
353 
Zuranolone
Depression Depressive Diso… Depressive Diso… Major Depressiv…
Internal company decision
The study was stopped prematurely and therefore data was not collected and analyzed for any efficacy outcome measure planned for the DB Phase of the study.
NCT03867370
Details
2023-11-29
Interventional
1/240 
Lenvatinib
Carcinoma Carcinoma, Hepa… Hepatocellular …
Enrollment is over, the study was completed
-
NCT03771664
Details
2023-11-29
Interventional
387 
Zuranolone
Depression Depressive Diso… Depressive Diso… Sleep Initiatio… Insomnia Major Depressiv…
internal company decision
The study was terminated early due to sponsor's decision and there were no safety concerns.
NCT02780128
Details
2023-11-29
Interventional
166 
Ceritinib
Neuroblastoma Cancer
The goals of Part 1 (molecular screening) were met, but lack of therapies to match molecular aberrations made Part 2 (treatment) no longer feasible.
-
NCT05284812
Details
2023-11-28
Interventional
2-
Vaccines
Tuberculosis
It is planned to restart the clinical study after the completion of the clinical trial protocol modification.
-
NCT05065567
Details
2023-11-28
Interventional
238 
Droperidol Haloperidol Haloperidol dec… Ondansetron
Hyperemesis Gra… Syndrome Vomiting Cyclic Vomiting…
Lost too many patients to follow up, unable to enroll enough patients
-
NCT04158141
Details
2023-11-28
Interventional
316 
Carboplatin Cisplatin Pemetrexed
Lung Neoplasms Mesothelioma Mesothelioma, M… Pleural Biphasi… Pleural Epithel… Stage I Pleural… Stage IA Pleura… Stage IB Pleura… Stage II Pleura… Stage IIIA Pleu…
Permanent Administrative Closure
-
NCT04301011
Details
2023-11-27
Interventional
1/227 
Pembrolizumab
Carcinoma Carcinoma, Squa… Melanoma Mesothelioma Mesothelioma, M… Oropharyngeal N… Squamous Cell C… Uterine Cervica… Cervical Cancer Cutaneous Squam… HPV Positive Or… Melanoma (Skin) Microsatellite … Oropharynx Canc… Renal Cell Carc… Solid Tumor
Sponsor decision
-
NCT03119012
Details
2023-11-27
Interventional
4-
Aspirin Clopidogrel Ticagrelor
Atherosclerosis Coronary Artery… Coronary Diseas… Myocardial Isch… Stents
cannot use bioabsorbable scaffold
-
NCT02842424
Details
2023-11-27
Interventional
4-
Ramipril
Intermittent Cl… Peripheral Arte… Peripheral Vasc…
IRB administratively closed protocol
-
NCT02176863
2013-004503-39
Details
2023-11-27
Interventional
2/3191 
Immunoglobulins Immunoglobulins… Rho(D) Immune G… gamma-Globulins
Poliomyelitis Postpoliomyelit… Syndrome Post-polio Synd…
-
-
NCT01720563
Details
2023-11-27
Interventional
217 
Leucovorin Tegafur
Carcinoma Carcinoma, Squa… Fatigue Squamous Cell C… Cancer-related …
Change study drug dosage form
-
NCT05115838
2021-003414-39
Details
2023-11-24
Interventional
20 
Islatravir
Acquired Immuno… HIV Infections Immunologic Def… HIV Human Immunodef…
Business Reasons
-
NCT04629209
Details
2023-11-24
Interventional
20 
TIC10 compound
Glioblastoma
Change in approach to study.
-
NCT03824327
Details
2023-11-24
Interventional
1-
Papaverine
Carcinoma, Non-… Lung Non-Small …
Per an amendment
-
NCT03496623
Details
2023-11-24
Interventional
3188 
Pharmaceutical … Treprostinil
Hypertension Hypertension, P… Lung Diseases Lung Diseases, … Pulmonary Disea… Chronic Obstruc… Pulmonary Hyper…
Sponsor's decision
Per sponsor decision, the study was terminated early. Data were not collected for the secondary outcome measures due to study termination and lack of appropriate sample size.
NCT02168270
Details
2023-11-24
Interventional
14 
Ascorbic Acid Temozolomide
Astrocytoma Glioblastoma Gliosarcoma Oligodendroglio… Anaplastic Astr… Anaplastic Olig… Anaplastic Olig…
-
-
NCT05998941
Details
2023-11-22
Interventional
20 
Bevacizumab Carboplatin Paclitaxel
Uterine Cervica… Cervical Cancer
Slow progress in development, the sponsor decided to withdraw and no longer proceed.
-