Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00460473
Details
2015-07-24
Interventional
352 
Dexmedetomidine
Delirium
The incidence of post-operative delirium observed from interim blinded data was significantly lower than the current literature in this population.
-
NCT02137564
Details
2015-07-23
Interventional
20 
Gamma Secretase… Nirogacestat
Sarcoma Sarcoma, Kaposi AIDS-related Ka… HIV Infection Recurrent Kapos…
Drug supply unavailable
-
NCT00788424
Details
2015-07-23
Interventional
20 
Ammonium trichl…
Psoriasis Mild to Moderat…
Sponsor's considerations
-
NCT01796522
Details
2015-07-22
Interventional
30 
Nifedipine Progesterone
Premature Birth Preterm Deliver…
have been published new studies that it showed the ineffectiveness of the treatments proposed in this study.
-
NCT01444118
Details
2015-07-22
Interventional
3-
Cyclophosphamid… Monatide (IMS 3… Vaccines
Carcinoma, Non-…
The early termination is not related to safety/toxicity but to initiate new Phase III with biomarker to enrich population & to further strengthen OS benefit
-
NCT01517776
2009-011898-33
Details
2015-07-21
Interventional
228 
Temozolomide
Diffuse Intrins… Glioma Gliomas
due to an altered benefit/risk assessment.
-
NCT00871273
Details
2015-07-21
Interventional
413 
Capecitabine
Adenocarcinoma Adenocarcinoma …
1. Slow recruitment; 2. Change to clinical environment reducing the pool of potentially eligible patients; 3. Availability of data from another similar study
-
NCT02397395
2014-004250-34
Details
2015-07-17
Interventional
20 
Simeprevir
Hepatitis C Hepatitis C, Ch… Kidney Diseases Kidney Failure,… Renal Insuffici… End-stage Renal… Renal Impairmen…
Trial has been cancelled due to availability of new therapeutic options for patient population
-
NCT01227434
Details
2015-07-17
Interventional
223 
Palbociclib
Astrocytoma Glioblastoma Gliosarcoma Anaplastic Astr…
-
-
NCT01642433
Details
2015-07-16
Interventional
21 
Prazosin
Tobacco Use Dis… Nicotine Depend…
-
-
NCT01848652
Details
2015-07-14
Interventional
25 
Doxorubicin
Lymphoma Lymphoma, B-Cel… Cerebral Lympho…
The laboratory's partner on this study decides to terminate the contract with the CHRU Brest, because of the difficulty of the recruitment.
-
NCT01282151
Details
2015-07-14
Interventional
3148 
Cisplatin Docetaxel Pemetrexed
Carcinoma, Non-… Carcinoma, Non …
Difficulty in recruitment due to approval of maintenance pemetrexed treatment
-
NCT00779285
2004-001177-25
Details
2015-07-14
Interventional
41 
Doxorubicin Liposomal doxor…
Breast Neoplasm… Breast Neoplasm
-
-
NCT01928160
Details
2015-07-13
Interventional
20 
Carboplatin Erlotinib Hydro… Pemetrexed
Carcinoma, Non-… Lung Neoplasms Recurrent Non-s… Stage IV Non-sm…
study not accruing
-
NCT01443923
Details
2015-07-13
Interventional
44 
Interferon alph… Interferon-alph… Interferons Peginterferon a… Ribavirin
Hepatitis Hepatitis A HIV/AIDS
Unable to complete enrollment due to newly approved treatment options.
-
NCT01039545
Details
2015-07-09
Interventional
4253 
Diclofenac Norfloxacin
Communicable Di… Infections Urinary Tract I…
New power calculation (reduction of necessary patient number)
-
NCT00905398
Details
2015-07-09
Interventional
1/28 
Nilotinib
Leukemia Leukemia, Lymph… Precursor B-Cel… Precursor Cell … Acute Lymphobla…
The study was terminated due to excessive toxicity and low compliance to the protocol scheme.
-
NCT01843309
Details
2015-07-07
Interventional
436 
Spironolactone
Congenital Abno… Patients With F…
Not possible to complete the sample within the estimated time by the use of new antifungals
-
NCT00486720
Details
2015-07-03
Interventional
222 
Vorinostat
Bone Marrow Dis… Hematologic Dis… Myelodysplastic… Preleukemia Syndrome Blood Disease Bone Marrow Dis…
-
This trial was terminated because the pre-specified futility criterion was met.
NCT00473889
Details
2015-07-03
Interventional
2/3253 
Carboplatin Paclitaxel Vorinostat
Carcinoma, Non-… Lung Neoplasms Stage IIIB or I…
The study was terminated based on the recommendation by the DSMB following a pre-planned protocol interim analysis because the endpoint was not achieved.
The study was stopped following a pre-planned interim analysis because the goal for this study to continue was not met, based on 100 events, a reduction in the hazard ratio for progression-free survival by > 23% with a one-sided p-value < 0.1