Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00216762
Details
2015-09-02
Interventional
1/2
[3 Refs]
-
Rituximab
Chronic Urticar… Urticaria
Full Clinical Hold
-
NCT00986778
Details
2015-09-01
Interventional
40 
Adefovir Entecavir Lamivudine
Hepatitis Hepatitis B Hepatitis B, Ch…
Business Objectives Changed
-
NCT01348503
Details
2015-08-31
Interventional
15 
Lenalidomide Sorafenib
Carcinoma Carcinoma, Hepa… Hepatocellular …
Treatment was ineffective
-
NCT00391313
2006-002624-42
Details
2015-08-28
Interventional
3-
Chloroquine
Chikungunya Fev… Chikungunya Vir…
Terminated Chikungunya diseases has regressed and no more patients was suffering
-
NCT01281163
Details
2015-08-27
Interventional
14 
Lapatinib
Breast Neoplasm… Estrogen Recept… Estrogen Recept… HER2/Neu Positi… Progesterone Re… Progesterone Re… Recurrent Breas… Stage IV Breast…
-
-
NCT00983047
Details
2015-08-27
Interventional
230 
Docetaxel Nimotuzumab
Carcinoma, Non-… Lung Neoplasms Advanced Non-Sm…
The sponsor decide to terminate
-
NCT00050336
Details
2015-08-27
Interventional
3702 
Lonafarnib
Carcinoma, Non-… Lung Neoplasms Neoplasm Metast… Carcinoma, Non-… Metastases, Neo…
-
-
NCT01575028
Details
2015-08-24
Interventional
23 
Bupivacaine Ropivacaine
Appendicitis
The study was allowed to expire due to changes in standard care for the patient population within the NCH institution.
-
NCT01172509
Details
2015-08-21
Interventional
16 
Baclofen
Autism
too much variability in the TMS measures
-
NCT00475917
Details
2015-08-21
Interventional
128 
Gemcitabine
Neoplasms Cancer Lymphoma
-
-
NCT02109224
Details
2015-08-20
Interventional
172 
Ibrutinib
Acquired Immuno… Burkitt Lymphom… Castleman Disea… HIV Infections Hyperplasia Infections Intraocular Lym… Leukemia Leukemia, Hairy… Leukemia, Lymph… Leukemia, Lymph… Lymphoma Lymphoma, B-Cel… Lymphoma, B-Cel… Lymphoma, Folli… Lymphoma, Large… Lymphoma, Large… Lymphoma, Mantl… Lymphoma, Non-H… Lymphomatoid Gr… Multiple Myelom… Plasmablastic L… Precursor Cell … Recurrence Waldenstrom Mac… Adult B Acute L… Chronic Lymphoc… Cutaneous B-Cel… Extranodal Marg… HIV Infection Multicentric An… Nodal Marginal … Recurrent Adult… Recurrent Adult… Recurrent Adult… Recurrent Adult… Recurrent Adult… Recurrent Adult… Recurrent Adult… Recurrent Adult… Recurrent Grade… Recurrent Grade… Recurrent Grade… Recurrent Mantl… Recurrent Margi… Recurrent Small… Refractory Chro… Refractory Hair… Refractory Plas… Small Intestina… Splenic Margina… Testicular Lymp…
Inadequate accrual rate
-
NCT00542711
Details
2015-08-20
Interventional
10 
Curcumin
Healthy
Technical difficulties
-
NCT00954005
Details
2015-08-19
Interventional
1/256 
Gemcitabine Oxaliplatin Rituximab
Lymphoma Indolent Lympho…
Predefined termination criterion of > 10 patients without CR or PR was matched.
-
NCT01754623
Details
2015-08-13
Interventional
29 
Capecitabine Docetaxel Fluorouracil Gemcitabine
Pancreatic Neop… Pancreatic Canc…
Lack of pre-treatment tissue to make the study plan feasible.
The study only accrued 9 (of planned 35) participants. It was not possible to collect adequate pre-treatment tissue for radiosensitivity index (RSI) analysis, pre-treatment. The study was terminated before planned completion.
NCT01666236
Details
2015-08-13
Interventional
4
[1 Refs]
0 
Ranibizumab Triamcinolone Verteporfin
Choroidal Neova… Dissociative Di… Neovascularizat… Polypoidal Chor… Retinal Detachm… Vascular Diseas… Retinal Pigment…
Lack of resources
-
NCT01117987
2009-018167-26
Details
2015-08-13
Interventional
3144 
Imatinib Mesyla…
Familial Primar… Hypertension Pulmonary Arter…
Novartis discontinued the development of imatinib in PAH due to requirement of regulatory authorities for additional data to secure marketing approval in PAH.
Within primary outcome measure (OM) #1, an additional death (>30 days post study completion) was included in the imatinib arm. The participant flow and secondary OM #2 reflect deaths that occurred up to and including 30 days post study completion.
NCT01392495
2010-021960-14
Details
2015-08-10
Interventional
317 
Imatinib Mesyla…
Familial Primar… Hypertension Pulmonary Arter…
Novartis discontinued the development of imatinib in PAH due to requirement of regulatory authorities for additional data to secure marketing approval in PAH.
-
NCT01009203
Details
2015-08-10
Interventional
2
[1 Refs]
13 
Erlotinib Hydro… MTOR Inhibitors Sirolimus Temsirolimus
Carcinoma Carcinoma, Squa… Squamous Cell C…
High patient withdrawal rate
-
NCT00440440
Details
2015-08-10
Interventional
40 
Testosterone
Hypogonadism Diabetes
study merged with another study
-
NCT02062996
Details
2015-08-07
Interventional
20 
Oxymetazoline Phenylephrine
Dental Anesthes… Intranasal Drug… Nasal Surgical …
Could not receive FDA approval for IND
-