Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02435836
Details
2015-09-21
Interventional
3631 
Aripiprazole
Schizophrenia
Study terminated when aripiprazole available commercially per protocol
The study was terminated prematurely by the sponsor. The protocol specified that the study would run until Abilify (aripiprazole) was commercially available in all site countries.
NCT02480010
Details
2015-09-18
Interventional
268 
Pertuzumab
Prostatic Neopl… Prostate Cancer
The study was terminated at the time of interim analysis since none of the participants showed a PSA response.
The study was terminated at the time of interim analysis since none of the participants showed a PSA response.
NCT02053597
2013-000173-77
Details
2015-09-17
Interventional
20 
Doxorubicin Paclitaxel
Breast Neoplasm… Breast Cancer
due to evolving scientific knowledge in the field that would make the questions being addressed in the trial less relevant
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NCT02338050
Details
2015-09-16
Interventional
21 
Immunotoxin HA2…
Leukemia Leukemia, Lymph… Neoplasm, Resid… Precursor Cell … Acute Lymphobla…
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NCT02408419
Details
2015-09-14
Interventional
40 
Bupivacaine
Fractures, Bone Hip Fractures
The study was completely redesigned
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NCT02248870
Details
2015-09-14
Interventional
47 
Dexamethasone
Fractures, Bone Hip Fractures Hip Fracture
Less inclusions than expected with the given criteria
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NCT01112878
Details
2015-09-14
Interventional
40 
Clonidine Gabapentin
Knee Arthroscop… Shoulder Arthro…
Several studies going on at the same time.
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NCT00782951
2006-002571-40
Details
2015-09-14
Interventional
211 
Morphine
Tooth, Impacted Analgesia
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NCT00953706
2009-010261-23
Details
2015-09-11
Interventional
2140 
Ivacaftor
Cystic Fibrosis Fibrosis
Following review of results obtained from a pre-specified 6-month analysis of Part B data the study was terminated on the basis of futility.
In Part B, the treatment duration was 96 weeks; however, due to early study termination all analysis were performed up to Week 64, as planned.
NCT00479466
Details
2015-09-09
Interventional
2342 
Metformin
Diabetes Mellit… Diabetes Mellit…
Sufficient data regarding the dose-response to MK-0893 had been obtained from the first cohort of the study to assess the safety and efficacy
Sufficient data regarding the dose-response to MK-0893 had been obtained from the first cohort of the study to assess the safety and efficacy, thus the study was discontinued.
NCT02090348
2013-001025-53
Details
2015-09-07
Interventional
40 
Dimethyl Fumara…
Multiple Sclero… Multiple Sclero… Sclerosis Relapsing-Remit…
The study was withdrawn for business reasons. The decision to stop the TECNERGY study was not a result of any safety or efficacy concerns.
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NCT01179100
Details
2015-09-07
Interventional
40 
Lidocaine
Elderly General Anesthe… Surgeries Requi…
Patient population require high amount of opioids.
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NCT01057212
Details
2015-09-07
Interventional
26 
Bevacizumab
Carcinoma, Non-… Lung Neoplasms Non-squamous No…
Lack of support from pharmaceutical collaborator.
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NCT00460317
Details
2015-09-07
Interventional
31450 
Carboplatin Motesanib dipho… Paclitaxel
Carcinoma, Non-… Lung Neoplasms Non-Small Cell …
Amgen discontinued the development of AMG706 because 20050201 did not meet its primary objective.
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NCT00395057
Details
2015-09-07
Interventional
2138 
Ranibizumab
Choroidal Neova… Macular Degener… Neovascularizat… Age-Related Mac… Choroid Neovasc…
The study was terminated early due to company decision (non-safety related).
The study was terminated early due to a company decision (non-safety related). Because the study was terminated early, data for certain outcome measures (ie, "Visual Functioning Questionnaire [VFQ] at Month 3") were not analyzed.
NCT02331563
Details
2015-09-04
Interventional
30 
Bupivacaine Dexmedetomidine
Postoperative N… Vomiting
patients should have assurance to attend this study, money is the main problem
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NCT01238133
Details
2015-09-04
Interventional
114 
2,2-dimethyl-N-… Albumin-Bound P… Carboplatin Gamma Secretase… Paclitaxel
Breast Neoplasm… Triple Negative… Estrogen Recept… HER2/Neu Negati… Progesterone Re… Stage IIA Breas… Stage IIB Breas… Stage IIIA Brea… Stage IIIB Brea… Stage IIIC Brea… Triple-Negative…
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NCT01184287
Details
2015-09-02
Interventional
20 
Ranpirnase
Carcinoma, Non-… Lung Neoplasms Non-Small Cell …
Program discontinued
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NCT00423163
Details
2015-09-02
Interventional
40 
Micafungin Voriconazole
Aspergillosis Aspergillosis/B… Aspergillosis/I…
An alternative joint industry effort will provide information on combination versus single agent therapy for treatment of aspergillosis
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NCT00331045
Details
2015-09-02
Interventional
221 
Alvimopan
Constipation Cancer
Subject registration did not proceed as expected; difficult to complete within scheduled time frame; prematurely terminated w/ 21 subjects randomized.
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