Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00276991
NCT00385424
NCT00505193
NCT00554060
Details
2015-11-04
Interventional
1/240 
Immunomodulatin…
HIV Infections
Lack of funding prevented the recruitment of 1000 HIV Patients all over India
-
NCT02461186
Details
2015-11-03
Interventional
2/30 
Artenimol Piperaquine
Malaria Malaria, Falcip… Artemisinin-res… Uncomplicated F…
Change of the study site due to the current political climate in Myanmar.
-
NCT01842594
Details
2015-11-03
Interventional
213 
Hydroxychloroqu… Sirolimus
Sarcoma
Most patients completed only the primary objective (PET) and not went throught the secondary outcome (efficacy phase) of 8wks period.
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NCT01583647
2012-001443-49
Details
2015-11-03
Interventional
110 
Niacin Niacinamide Nicotinic Acids
Hypercholestero… Hyperlipoprotei… Heterozygous Fa… Hypercholestero…
In HPS2-THRIVE, MK-0524A did not meet the primary efficacy objective and there was a significant increase in incidence of some types of non-fatal SAEs.
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NCT01095250
2009-014834-22
Details
2015-11-03
Interventional
330 
Antibodies, Mon…
Uveitis
Terminated: Study in Behcet's disease with mostly active uveitis did not meet its primary endpoint.
Study CAIN457C2302 was terminated to avoid continuing patients on a study with a low probability of success. Since patients did not reach the endpoint of analysis there can be no meaningful interpretation of data and data will be not provided.
NCT00362245
Details
2015-11-03
Interventional
40 
Amikacin
Meningitis Meningitis, Bac… Gram Negative M… Post Traumatic …
lack of participants
-
NCT01245543
Details
2015-11-01
Interventional
10 
Docetaxel
Neoplasms Solid Tumors
Clinical investigations have been discontinued and transfer to BMS 3/24/2015
-
NCT00968617
Details
2015-11-01
Interventional
27 
Darbepoetin alf…
Anemia Kidney Diseases Renal Insuffici… Chronic Kidney …
-
Cohort 1 (MK2578 1.0 mcg/kg) was the only cohort initiated because the study was prematurely terminated by the sponsor. 7 participants received at least 1 dose of MK2578 & 2 participants received all 3 doses. Data presented are for Cohort 1.
NCT00924781
Details
2015-11-01
Interventional
239 
Epoetin Alfa
Anemia Kidney Diseases Renal Insuffici… Chronic Kidney …
-
Cohort 3 (MK2578 1mcg/200U) was not initiated because the study was prematurely terminated by the sponsor. All randomized participants received at least one dose of study medication. Data presented are for Cohort 1 and Cohort 2, where applicable.
NCT00692614
Details
2015-11-01
Interventional
22 
Triamcinolone Triamcinolone A… Triamcinolone d… Triamcinolone h…
Edema Macular Edema
-
-
NCT00479089
Details
2015-11-01
Interventional
250 
Dexamethasone Docetaxel Gefitinib
Urinary Bladder… Bladder Cancer
Study halted due to drug sponsor decision to not continue.
Early termination leading to small numbers of subjects analyzed.
NCT01381666
Details
2015-10-29
Interventional
222 
Pharmaceutical …
Lung Diseases Lung Diseases, … Interstitial Lu…
-
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NCT00418470
Details
2015-10-29
Interventional
4-
Anti-Bacterial … Antibiotics, An…
Cystic Fibrosis Fibrosis Phlebitis
impossibility to find volunteers
-
NCT01910441
Details
2015-10-28
Interventional
495 
Glimepiride Metformin Vildagliptin
Diabetes Mellit… Diabetes Mellit… Type 2 Diabetes…
The study was terminated due to the unavailability of Continuous Glucose Monitoring sensors (CGMS) which were required to assess the primary end-point.
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NCT01273181
Details
2015-10-28
Interventional
1/29 
Aldesleukin Cyclophosphamid… Fludarabine
Kidney Neoplasm… Melanoma Neoplasm Metast… Neoplasms Neoplasms, Seco… Metastatic Canc… Metastatic Mela… Metastatic Rena…
-
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NCT00924287
NCT00805987
Details
2015-10-28
Interventional
1/21 
Aldesleukin Cyclophosphamid… Fludarabine Interleukin-2 Mesna
Neoplasm Metast… Neoplasms Neoplasms, Seco… Metastatic Canc…
This study was terminated after the first patient treated on study died as a result of the treatment.
This study was terminated after the first patient on study died as a result of the treatment.
NCT00671112
Details
2015-10-28
Interventional
130 
Bortezomib Everolimus
Leukemia Lymphoma 714leukemia
Treatment ineffective
-
NCT00372996
2006-005573-21
Details
2015-10-28
Interventional
2219 
Exemestane Fulvestrant
Breast Neoplasm…
This study was closed to enrollment as of 13 May 2011 due to business reasons. Premature closure was not prompted by any safety or efficacy concerns.
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NCT00282399
Details
2015-10-28
Interventional
141 
Decitabine
Myelodysplastic… Preleukemia Syndrome Myelodysplastic…
-
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NCT00670150
Details
2015-10-27
Interventional
20 
Arsenic Trioxid…
Leukemia Leukemia, Promy… Acute Promyeloc…
sponsor withdrew support
-