Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01542242
Details
2015-12-09
Interventional
41 
Liraglutide
Diabetes Mellit… Diabetes Mellit… Prader-Willi Sy… Syndrome Diabetes Mellit… Prader Willi Sy…
Subject withdrew
-
NCT00076206
Details
2015-12-09
Interventional
2-
Temsirolimus
Arthritis Arthritis, Rheu… Rheumatoid Arth…
-
-
NCT00864513
Details
2015-12-08
Interventional
217 
Pemetrexed
Pancreatic Neop… Pancreas Cancer
At interim analysis the study did not meet the response criteria to continue
study was closed at interim analysis so only 12 subjects were evaluable for response, 15 subjects received treatment and were evaluable for adverse events
NCT02054936
Details
2015-12-07
Interventional
40 
Rivaroxaban Warfarin
Complications; …
Change in standard of care, no possibility of recruitment
-
NCT00754884
Details
2015-12-04
Interventional
40 
Calcitonin Calcitonin Gene… Glycerol Katacalcin Salmon calciton…
Fibromyalgia Myofascial Pain…
Study drug was not longer available in our country.
-
NCT00538187
Details
2015-12-04
Interventional
118 
Bortezomib Obatoclax
Leukemia, Lymph… Lymphoma Lymphoma, Folli… Lymphoma, Large… Lymphoma, Mantl… Lymphoma, Non-H… Recurrence Adult Non-Hodgk… Recurrent Adult… Recurrent Grade… Recurrent Grade… Recurrent Grade… Recurrent Mantl… Recurrent Margi… Recurrent Small…
-
-
NCT00381836
2005-005658-37
Details
2015-12-04
Interventional
2/3-
Darbepoetin alf…
Anemia Prostatic Neopl…
Terminated by sponsor due to general risk that aranesp caused tumor progression
-
NCT02177760
Details
2015-12-03
Interventional
20 
Sirolimus
Immunologic Def… Severe Combined… Stem Cell Trans… Transplacental …
Preliminary data suggested a better approach available
-
NCT00970086
Details
2015-12-03
Interventional
422 
Bupivacaine Levobupivacaine
Pain, Postopera… Postoperative P… Reaction; Anest…
Groin surgery was changed to a laparoscopic technique; recruitable patients ceased.
-
NCT00599131
Details
2015-12-03
Interventional
24 
Cetuximab Docetaxel Fluorouracil
Laryngeal Neopl… Cancer of Laryn…
The study was discontinued prematurely due to early stopping rules.
The study was discontinued prematurely due to an early stopping rule.
NCT01953744
Details
2015-12-02
Interventional
353 
Fluconazole Meglumine Antim…
Leishmaniasis Leishmaniasis, … Cutaneous Leish…
Low cure rate in the study (fluconazole) group
-
NCT01730495
2011-006069-16
Details
2015-12-02
Interventional
24 
Etanercept
Encephalomyelit… Fatigue Fatigue Syndrom… Myalgia Necrosis Syndrome Chronic Fatigue… Myalgic Encepha…
After inclusion of four patients, two experienced moderate worsening of symptoms
-
NCT01600963
2011-000653-23
Details
2015-12-02
Interventional
30 
Bedaquiline Diarylquinoline…
Tuberculosis Tuberculosis, M… Multi-drug Resi…
PhIII program revised; TMC207-C210 cancelled
-
NCT00313612
Details
2015-11-27
Interventional
2
[1 Refs]
39 
Oxaliplatin Topotecan
Carcinoma, Ovar… Recurrent Ovari…
-
-
NCT02336308
Details
2015-11-26
Interventional
40 
Ketamine
Hyperalgesia Anxiety Pain Thermal Hyperal…
Standard of care for dressing changes at the institution now includes treatment intervention
-
NCT01381731
Details
2015-11-25
Interventional
214 
Ophthalmic Solu…
Photorefractive…
-
-
NCT02106520
Details
2015-11-20
Interventional
2/380 
Bevacizumab
Epistaxis Telangiectasia,… Telangiectasis Hereditary Hemo…
DSMB's decision following the first step analysis
-
NCT00988169
Details
2015-11-20
Interventional
26 
Erlotinib Hydro…
Lung Neoplasms Lung Cancer
-
-
NCT00982657
2010-022657-42
Details
2015-11-20
Interventional
234 
Sunitinib
Carcinoma, Rena… Solid Tumor
Refer to statement in Summary Section/Detailed Description
On 25 Oct 2012, due to data safety signals in separate clinical trial with CVX-060, all CVX-060 studies were discontinued. Ongoing participants in B1131001 were permitted to remain on study at a reduced dose if determined to derive clinical benefit.
NCT00975416
Details
2015-11-20
Interventional
463 
Oxytocin
Substance-Relat… Drug Dependence
-
1 participant committed suicide outside of that occurred outside of adverse event time frame. There were 12 occurrences of computer malfunction during the study. This did not effect data collection for primary outcome measures.