Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT05646459
Details
2023-12-04
Interventional
10 
Cannabidiol
Chronic Periodo… Gingivitis Inflammation Periodontitis Inflammation Gu… Periodontitis, …
Study was unable to obtain IRB approval because CBD was not legal in Nebraska at that time.
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NCT05321940
Details
2023-12-04
Interventional
10 
Interferons Vaccines
Leukemia Leukemia, Myelo… Leukemia, Myelo… Leukemia, T-Cel… Leukemia-Lympho… Precursor Cell … Acute Lymphobla… Acute Myelogeno… Adult T-Cell Le… Refractory Leuk… Relapsed Leukem…
Investigator decision
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NCT05111002
Details
2023-12-04
Interventional
1/212 
Doxycycline Lefamulin
Mycoplasma Infe… Pleuropneumonia Mycoplasma Geni…
At Sponsor Request
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NCT04690855
Details
2023-12-04
Interventional
21 
Atezolizumab Talazoparib
Breast Neoplasm… Triple Negative… Breast Cancer Triple Negative…
This study has been terminated due to Lack of Accrual.
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NCT03733067
Details
2023-12-04
Interventional
1/20 
Abatacept
Anemia Cytopenia Leukopenia Thrombocytopeni… CTLA4 Haploinsu… Chronic Cytopen…
No enrollment
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NCT02420717
Details
2023-12-04
Interventional
211 
Antibodies Antibodies, Mon… Antineoplastic … BB 1101 Cortisone Cyclophosphamid… Cytarabine Dasatinib Daunorubicin Dexamethasone Dexamethasone a… Doxorubicin Immunoglobulins Leucovorin Liposomal doxor… Mercaptopurine Methotrexate Prednisone Rituximab Vincristine
Leukemia Leukemia, Lymph… Philadelphia Ch… Precursor Cell … Recurrence Recurrent B Acu… Recurrent Ph-Li… Refractory B Ac… Refractory Ph-L…
Study was closed early due to low accrual and lack of response.
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NCT00752479
2009-012350-20
Details
2023-12-04
Interventional
1/24 
Basiliximab Cyclosporine Cyclosporins Methylprednisol… Methylprednisol… Methylprednisol… Mycophenolic Ac… Prednisolone Prednisolone ac… Prednisolone he… Prednisolone ph… Thymoglobulin
Kidney Transpla…
Necessity of major revision of the protocol
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NCT00592280
Details
2023-12-04
Interventional
17 
Pancreatin Pancrelipase
Pancreatitis Pancreatitis, G… Graft Pancreati…
Logistic problems with adequately timely organ collection and transport
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NCT06153186
Details
2023-12-01
Interventional
29 
Flunarizine
Epilepsies, Myo… Epilepsy Epilepsy, Absen… Myoclonic Epile… Childhood Absen… Juvenile Absenc… Juvenile Myoclo…
The enrollment wasn't as predicted. We didn't have enough numbers to show statistical significance.
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NCT05676463
Details
2023-12-01
Interventional
2-
Androgen Antago… Androgens Ascorbic Acid Estrogens, Conj… Hormones Methyltestoster…
Prostatic Neopl… Prostate Adenoc… Stage IIIB Pros… Stage IIIC Pros…
on hold due to pause of outside company
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NCT05157464
Details
2023-12-01
Interventional
40 
Losartan
Arthrofibrosis
Study was not initiated, no participants enrolled.
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NCT03478956
2017-003649-10
Details
2023-12-01
Interventional
124 
Etrolizumab
Colitis Colitis, Ulcera… Crohn Disease Ulcer Crohn's Disease Ulcerative Coli…
The study was terminated due to program discontinuation, based on mixed efficacy results in the adult ulcerative colitis and Crohn's disease studies. There were no safety concerns.
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NCT02626455
2015-001088-38
Details
2023-12-01
Interventional
3547 
Bendamustine Hy… Cyclophosphamid… Doxorubicin Prednisone Rituximab Vincristine
Lymphoma Lymphoma, Non-H…
The study did not meet the primary endpoint. The addition of copanlisib to standard immunochemo therapy did not improve progression-free survival compared to the control arm. Base on the study results, company decided to terminate the study.
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NCT01559129
2010-023047-15
Details
2023-12-01
Interventional
223 
Pomalidomide
Lung Diseases Lung Diseases, … Scleroderma, Di… Scleroderma, Lo… Scleroderma, Sy… Sclerosis Interstitial Lu… Sclerosis, Syst… Systemic Sclero… Systemic Sclero…
Enrollment was stopped early (see limitations and caveats section).
Based upon interim analysis data, the study did not meet its primary endpoints for subjects who had completed blinded treatment. The IDMC recommended the study be stopped due to lack of efficacy and the sponsor agreed with this recommendation.
NCT03970837
Details
2023-11-30
Interventional
31764 
Tofacitinib
Arthritis Arthritis, Rheu…
Only Asia cohort is early terminated.Limited efficacy demonstrated in the contRAst program does not support a suitable benefit/risk profile for otilimab as a potential treatment for RA. GSK has decided not to progress with regulatory submissions.
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NCT03819660
Details
2023-11-30
Interventional
213 
Amifampridine
Atrophy Muscular Atroph… Muscular Atroph… Spinal Muscular…
Development of indication not being pursued
The results of efficacy are limited to the assessment of quality of life using the INQoL. The premature interruption of the study determined that few patients had available data of INQoL from Month 6 onwards.
NCT03818672
Details
2023-11-30
Interventional
45 
Rifaximin
Liver Diseases Severe Hepatic …
Study determined to be infeasible.
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NCT03605758
Details
2023-11-30
Interventional
351 
Ivermectin
Communicable Di… Infections Strongyloidiasi… Strongyloides S…
The original study PI passed away. Primary and Study Completion dates revised to reflect last participant examination date.
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NCT01994824
Details
2023-11-30
Interventional
270 
Antilymphocyte … Thymoglobulin
Graft vs Host D… Graft-vs-host D…
The trend was observed toward higher mortality among the patients receiving the intervention Thymoglobulin on day 8 after hematopoietic cell transplantation.
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NCT01135199
Details
2023-11-30
Interventional
20 
Pomalidomide
Fibrosis Idiopathic Pulm… Pulmonary Fibro…
FDA did not accept sponsor's animal toxicology data to support proposed dosing.
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