Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00518245
Details
2016-01-27
Interventional
411 
Enoxaparin
Angina, Unstabl… Unstable Angina
Low rate of patient recruitment. Cannot achieve sample size.
-
NCT00889590
Details
2016-01-26
Interventional
215 
Zoledronic Acid
Bone Neoplasms Giant Cell Tumo… Giant Cell Tumo… Osteoclastoma
low recruitment with registration denosumab
-
NCT00429754
Details
2016-01-26
Interventional
40 
Aprepitant
Nausea Vomiting
change of study population and chemotherapeutic regimen
-
NCT02452281
Details
2016-01-25
Interventional
1/20 
Ipilimumab
Melanoma
PI departure, operational issues
-
NCT01628445
Details
2016-01-21
Interventional
352 
Liraglutide
Diabetes Mellit… Diabetes Mellit… Type 2 Diabetes
Error made by local pharmacy caused mixed randomization of 20 participants
-
NCT00832208
Details
2016-01-21
Interventional
2124 
Amphotericin B Liposomal ampho…
Leishmaniasis Leishmaniasis, … Visceral Leishm…
-
-
NCT00387036
Details
2016-01-21
Interventional
2
[1 Refs]
12 
Fluticasone
Lung Diseases Lung Diseases, … Pulmonary Disea… Chronic Obstruc…
Termininated for business reasons
-
NCT02217670
Details
2016-01-20
Interventional
10 
Metformin
Comparative Bio…
Commercial reasons
-
NCT02152514
Details
2016-01-20
Interventional
434 
Morphine Sufentanil
Pain, Postopera… Morphine Postoperative P… Rachianesthesia Sufentanil Thoracic Surger…
Due to technical details recruitment was unreasonably slow
-
NCT01871740
Details
2016-01-20
Interventional
40 
Enalapril Enalaprilat Folic Acid Maleic acid
Hyperhomocystei… Hypertension Kidney Diseases Renal Insuffici…
The sponsor and the PIs both agreed that the CSPPT-CKD should be a sub-study of the CSPPT insted of an independent randomized trial.
-
NCT00822900
Details
2016-01-20
Interventional
3882 
Progesterone
Brain Injuries Brain Injuries,… Wounds and Inju… Traumatic Brain…
futility: low conditional power to demonstrate benefit of progesterone
The trial was stopped early for futility with respect to the primary outcome.
NCT00437671
Details
2016-01-20
Interventional
46 
Antibodies Immunoglobulins Immunoglobulins… Rho(D) Immune G… gamma-Globulins
Tetanus Tetany
Study terminated for cGCP non-compliance. Analyses could not be performed.
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NCT00800787
Details
2016-01-18
Interventional
30 
Immunoglobulins
Hepatitis Hepatitis A Hepatitis B Hepatitis B, Ch…
New sponsor's existing product under evaluation for this indication
-
NCT00711906
Details
2016-01-18
Interventional
3352 
Fanasil, pyrime… Pyrimethamine Sulfadoxine Trimethoprim, S…
Malaria Malaria in Preg…
Malaria prev. fell in the study area, so we cannot evaluate the primary endpoint
-
NCT00582114
Details
2016-01-18
Interventional
3200 
Atenolol Lisinopril
Hypertension Hypertrophy Hypertrophy, Le… Hemodialysis Left Ventricula…
Stopped by data safety monitoring board
-
NCT01801228
2011-001264-22
2011-001264-22
Details
2016-01-15
Interventional
20 
Eplerenone
Ascites Fibrosis Liver Cirrhosis Cirrhosis
difficulties to include patients
-
NCT00660036
Details
2016-01-15
Interventional
15 
Etoposide Gemtuzumab Mitoxantrone
Leukemia Leukemia, Myelo… Leukemia, Myelo… Acute Myeloid L…
due to new safety information
-
NCT02365727
Details
2016-01-14
Interventional
40 
Bupivacaine Clonidine Epinephrine Ropivacaine
Osteoarthritis Osteoarthritis,… Knee Osteoarthr…
Protocol not feasible as written
-
NCT01925781
Details
2016-01-14
Interventional
410 
Nicotine
Behavior, Addic… Tobacco Use Dis… Nicotine Addict… Smoking Cessati…
IND required
-
NCT02433353
Details
2016-01-13
Interventional
40 
Venlafaxine Hyd…
Stress Disorder… Stress Disorder… Posttraumatic S…
PI was transferred to another base. No one else available to serve as PI.
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