Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00871039
Details
2016-03-01
Interventional
40 
Midazolam Propofol
Alcoholism Respiration, Ar…
Due to logistical purposes
-
NCT02362321
Details
2016-02-29
Interventional
420 
Dexamethasone
Hematoma Hematoma, Subdu… Hematoma, Subdu…
Due to serious adverse events
-
NCT00522301
Details
2016-02-29
Interventional
26 
Sorafenib
Carcinoma, Ovar… Fallopian Tube … Fallopian Tube … Ovarian Cancer Primary Periton…
-
Early termination as it would not meet it's primary endpoint of improved survival. None of the patients completed the study.
NCT00823095
Details
2016-02-26
Interventional
27 
Nitric Oxide
Leg Ulcer Ulcer Chronic Ulcer o…
Subject recuitment halted and won't resume; subjects are no longer being treated.
No data available for this study due to dissolution of company contracted to perform study analysis.
NCT00781482
Details
2016-02-26
Interventional
40 
Eszopiclone Zolpidem
Healthy
Sponsor elected not to conduct study at this time.
-
NCT00140790
Details
2016-02-26
Interventional
41000 
Valsartan
Renal Insuffici… Hypertension
The number of actual events was extremely low. We extended the study period, but it was still not enough. Also, many patients were loss of follow up.
-
NCT00370149
Details
2016-02-24
Interventional
4
[1 Refs]
326 
Anti-Bacterial …
Infections Infection Preve…
Blinded interim analysis resulted in early termination of the study.
A blinded interim analysis by an independent Data Safety Monitoring Board resulted in early termination of the study: of 288 evaluable patients, the rates of CRBSI and line-related complications were similar between the 2 groups.
NCT01093846
2009-013901-33
Details
2016-02-22
Interventional
359 
Antibodies, Mon…
Uveitis
Core Study in Behcet's disease with mostly active uveitis did not meet its primary endpoint
Due to early termination of the study AIN457C2303E1, the analysis of extension period was changed. No efficacy analyses were completed, the safety analyses were reduced to summary of AEs occurred during the extension and safety follow-up periods.
NCT00115063
Details
2016-02-22
Interventional
4390 
Diethylpropion Orlistat Sibutramine
Obesity
ethical issues of continuing control group without treatment
The study was stopped prematurely for efforts to be focused on assisting the Office of Group Benefits (OGB) in translating a policy that would allow for physician certification in order to offer participants the intensive treatment.
NCT00582400
Details
2016-02-19
Interventional
29 
Arsenic Trioxid…
Carcinoma Carcinoma, Hepa…
recruiting or enrolling participants has halted prematurely and will not resume; participants are no longer being examined or treated
-
NCT00483119
Details
2016-02-18
Interventional
29 
Antibodies Cyclophosphamid… Immunoglobulins Immunoglobulins… Rho(D) Immune G… gamma-Globulins
Pemphigus Pemphigus Vulga…
Study was terminated due to the death of the PI.
Sadly, the trial PI, Dr. Jean-Claude Bystryn, died on August 19, 2010. As a result the study could not be completed and an analysis of the data collected was not performed.
NCT02411877
Details
2016-02-17
Interventional
20 
Clotrimazole Miconazole
Hypothermia Ischemia Ischemic Stroke
It was decided that it was not feasible to continue this study.
-
NCT01497626
Details
2016-02-17
Interventional
115 
Bortezomib Lapatinib
Neoplasms Advanced Solid …
Drug support withdrawn
-
NCT00850161
Details
2016-02-15
Interventional
20 
Insulin Insulin Aspart Insulin, Globin…
Diabetes Mellit… Type 1 Diabetes…
Business purposes.
-
NCT00793468
Details
2016-02-15
Interventional
20 
Nicotine
Substance-Relat… Substance Depen…
Study halted prior to enrollment of patients
-
NCT00130936
Details
2016-02-15
Interventional
1/2-
Capecitabine Carboplatin Epirubicin
Esophageal Canc… Gastric Cancer Tumors
-
-
NCT02537561
Details
2016-02-11
Interventional
10 
Cisplatin Gemcitabine Talazoparib
Carcinoma Carcinoma, Non-… Lung Neoplasms Carcinoma, Non-… Non-Small Cell … Non-Small-Cell … Nonsmall Cell L… Solid Tumors
The pharmaceutical company did not want to follow through with support for the study.
-
NCT01200342
Details
2016-02-11
Interventional
27 
Carboplatin Oblimersen Paclitaxel
Melanoma
Pharmaceutical company no longer manufacturing investigational product.
-
NCT01888042
Details
2016-02-10
Interventional
261 
Everolimus
Carcinoma, Rena… Kidney Neoplasm… Kidney Cancer
-
-
NCT01534455
2010-023237-37
Details
2016-02-10
Interventional
243 
Lapatinib
Breast Neoplasm… Metastatic Brea…
very slow patient recruitment and concerns about the actuality of the study design
-