Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01859637
Details
2016-03-28
Interventional
46 
Lenograstim
Neutropenia Severe Chronic …
Additional pharmacovigilance activity was considered as fulfilled by the EMA.
This was an Additional Pharmacovigilance Activity (MEA005). Based on interim study data, complemented with clinical data from continued global development & extensive post-marketing experience MEA005 was considered fulfilled and the study terminated.
NCT01212094
Details
2016-03-28
Interventional
1/2
[1 Refs]
44 
Rituximab
Multiple Sclero… Multiple Sclero… Sclerosis
The efficacy on CSF biomarkers failed to reach criteria for continuation of the trial
The trial was closed prematurely for futility, because pre-determined interim analysis demonstrated that selected dosing led to <50% depletion of B cells from the brain/spinal cord. Therefore, only 5 patients per group finished trial.
NCT00286403
Details
2016-03-28
Interventional
2/30 
Fenoldopam
Acute Kidney In… Acute Renal Fai…
The study was terminated due to logistics at a local hospital.
-
NCT00652093
Details
2016-03-25
Interventional
424 
Acetaminophen Acetaminophen, … Dextropropoxyph… Levopropoxyphen… Oxymorphone
Constriction, P… Spinal Stenosis Lumbar Spinal S…
Removal of Darvocet from US market
This study terminated early (leading to small number of subjects analyzed) due to US Food and Drug Administration (FDA) removing active control (Darvocet) from the U.S. market.
NCT01930292
2012-003676-40
Details
2016-03-24
Interventional
131 
Carboplatin Paclitaxel
Solid Tumors
Part B was cancelled based on business decision
-
NCT01545635
Details
2016-03-23
Interventional
3100 
Thrombin
Blood Coagulati… Hemostatic Diso… Wounds and Inju… Major Trauma
The Interim analysis (100 patients) revealed a possible harm to patients randomised to the fresh frozen plasma (FFP) treatment arm.
-
NCT01329744
Details
2016-03-23
Interventional
116 
Mecasermin
Lipodystrophy Metabolic Disea… HIV Lipodystrop…
-
-
NCT00573157
Details
2016-03-23
Interventional
2/36 
Mycophenolic Ac…
Lupus Nephritis Nephritis
The study was terminated due to unanticipated safety issues
The study was terminated due to unanticipated safety issues.
NCT02426164
Details
2016-03-22
Interventional
40 
Bupivacaine Epinephrine Methylprednisol… Morphine
Pain, Postopera… Arthroplasty, R… Osteoarthritis
Could not receive facility approval
-
NCT00947895
Details
2016-03-22
Interventional
2/330 
Adrenocorticotr… Methylprednisol… Methylprednisol… Methylprednisol… Prednisolone Prednisolone ac… Prednisolone he… Prednisolone ph…
Multiple Sclero… Recurrence Sclerosis
Study reached halfway point in approximately one year time period and was halted to analyze data.
-
NCT00580216
2007-004817-33
Details
2016-03-21
Interventional
3
[1 Refs]
3773 
Biotin Idrabiotaparinu… Idraparinux Warfarin
Atrial Fibrilla… Thromboembolism
early discontinuation based on strategic sponsor decision not driven by any safety concern
-
NCT02713139
Details
2016-03-18
Interventional
30 
Clotrimazole Metronidazole Miconazole
Vaginal Dischar… Sexual Active W…
Due to budget limitations, the company decided to withdraw this study.
-
NCT02711241
Details
2016-03-17
Interventional
315 
Dipyrone Papaverine
Gastroenteritis
Not enough patients
-
NCT01737892
Details
2016-03-17
Interventional
1/221 
Epinephrine Epinephryl bora… Racepinephrine
Asthma
unable to validate analytical method
-
NCT01518153
Details
2016-03-17
Interventional
216 
Alemtuzumab Fludarabine Fludarabine pho… Melphalan Methotrexate Tacrolimus
Myeloproliferat… Leukemia Lymphoma Myeloma Myeloproliferat…
Objectives not met.
-
NCT01069796
Details
2016-03-17
Interventional
264 
Bevacizumab Capecitabine Paclitaxel
Breast Neoplasm… Triple Negative…
The number of inclusion was reached normally
-
NCT00522249
Details
2016-03-17
Interventional
1/210 
Erlotinib Hydro… Interferon-alfa… Interferon-alph… Interferons Peginterferon a… Sunitinib
Carcinoma Carcinoma, Rena…
PI decision
-
NCT00521274
Details
2016-03-17
Interventional
211 
Docetaxel
Prostatic Neopl…
Oxford BioMedica halted TroVax injections
-
NCT00450008
Details
2016-03-17
Interventional
29 
Docetaxel Thalidomide
Prostatic Neopl…
PI decision
-
NCT00447473
Details
2016-03-17
Interventional
231 
Ketoconazole Mitoxantrone
Prostatic Neopl…
PI decision
-