Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00609180
Details
2016-04-13
Interventional
3272 
Antioxidants
Acute Lung Inju… Lung Injury Respiratory Dis… Respiratory Dis… Syndrome Respiratory Dis…
The Omega arm of this study was stopped for futility. The EDEN arm continues to recruit patients as a separate independent study.
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NCT01941615
2013-000298-62
Details
2016-04-11
Interventional
118 
Ethinyl Estradi… Ethinyl estradi…
Healthy
-
This trial was prematurely discontinued during the run-in period. During the run-in period, subjects were to receive Microgynon® once daily for 21 to 49 days. The investigational products Deleobuvir + faldaprevir were not administered.
NCT01426555
Details
2016-04-11
Interventional
2/370 
Zoledronic Acid
Osteoporosis
Incomplete data set & analysis
No Data Safety Monitor Board established for this project. Incomplete data set and analysis.
NCT01023880
Details
2016-04-11
Interventional
1/262 
Delanzomib
Multiple Myelom… Neoplasms, Plas…
-
-
NCT02529241
Details
2016-04-08
Interventional
112 
Delpazolid Oxazolidinones
Healthy
-
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NCT02150499
Details
2016-04-08
Interventional
318 
Albuterol
Asthma Respiratory Asp…
-
-
NCT00227344
Details
2016-04-08
Interventional
4129 
Anti-Arrhythmia…
Atrial Fibrilla…
Study prematurely terminated due to randomization imbalance.
The study was terminated early due to randomization imbalance. The relatively small number of subjects enrolled limited the amount of data available for analysis. Because the study did not reach its targeted enrollment, the study is underpowered.
NCT02446028
Details
2016-04-07
Interventional
213 
Insulin Lispro
Diabetes Mellit…
IND Withdrawn
-
NCT01628913
2012-000769-19
Details
2016-04-07
Interventional
262 
Dactolisib Everolimus
Adenoma, Islet … Neuroendocrine … Pancreatic Neur…
This trial was terminated based on an interim analysis as BEZ235 did not demonstrate a progression free survival advantage to everolimus treatment.
Trial terminated based on the results of a pre-planned interim analysis of the primary OM ( which demonstrated BEX235 not having improved PFS (progression free survival) vs everolimus)..The secondary OM analyses were not conducted
NCT01222819
Details
2016-04-06
Interventional
4120 
Lenograstim
Neutropenia Leukemia
Physycians' refusal to continue the study
-
NCT00663234
Details
2016-04-06
Interventional
1/228 
Atorvastatin
Hyperlipidemias Hyperlipoprotei… HIV Infections Hyperlipidemia
The study was prematurely discontinued due to administrative reasons.
Target enrollment was 40 participants (20 in each age cohort). However, the study was prematurely discontinued due to administrative reasons, having enrolled only 28 participants (21 participants aged 10 to 14 and 7 participants aged 15 to 23).
NCT00383799
2005-001505-25
Details
2016-04-06
Interventional
4302 
Amiodarone Procainamide
Tachycardia Tachycardia, Ve… Ventricular Tac… Wide QRS Tachyc…
Steering Committee decision after inclusion of 74 patients after 6 years and very slow inclusion rate
-
NCT00219778
Details
2016-04-06
Interventional
2-
Mifepristone
Leiomyoma Myofibroma
-
-
NCT02137343
Details
2016-04-04
Interventional
334 
Capecitabine Rilotumumab
Stomach Neoplas… Gastric Cancer
All Amgen sponsored AMG102 clinical studies were terminated following a pre-planned Data Monitoring Committee safety review of study 20070622.
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NCT01230827
NCT01777399
2009-015019-42
Details
2016-04-04
Interventional
3173 
Golimumab Methotrexate
Arthritis Arthritis, Juve… Juvenile Idiopa…
Trial has failed to meet primary - and major secondary endpoints
-
NCT00960531
Details
2016-04-01
Interventional
2160 
Saponin QA-21V1
Alzheimer Disea…
-
In 2013 the sponsor decided that ACC-001 would not be further developed in mild to moderate Alzheimer's disease, study drug administration was discontinued, and remaining participants were followed for safety for up to 6 months after last injection.
NCT00462384
Details
2016-04-01
Interventional
339 
Epoetin Alfa
Anemia Kidney Diseases Renal Insuffici…
Strategic decision unrelated to safety or efficacy
This study was terminated early due to strategic decision unrelated to safety or efficacy.
NCT00608881
Details
2016-03-30
Interventional
3609 
Coenzyme Q10 Ubiquinone
Huntington Dise… Huntington's Di…
Futility analysis failed to showed likelihoo of benefit of CoQ 2400 mg/day.
An interim analysis for futility revealed a conditional power of < 5% for the primary analysis, and the trial was halted in July, 2014. Only data collected prior to this time were included in the final analyses.
NCT02720120
2004-002132-26
Details
2016-03-28
Interventional
1/2175 
Ocrelizumab
Arthritis Arthritis, Rheu… Rheumatoid Arth…
The overall benefit risk profile of ocrelizumab was not favorable in RA
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NCT02106364
Details
2016-03-28
Interventional
30 
Insulin Insulin Glargin… Insulin, Globin…
Diabetes Mellit… Diabetes Mellit…
Lilly's decision to cancel this trial is due to regulatory uncertainty in China.
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