Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01997255
Details
2016-05-05
Interventional
20 
Everolimus
Brain Stem Infa… Epilepsy Klippel-Trenaun… Sturge-Weber Sy… Syndrome Sturge Weber Sy…
Site did not want to pursue study
-
NCT01499251
Details
2016-05-05
Interventional
1-
Macitentan Temozolomide
Glioblastoma
Results did not clearly support continuing development in recurrent GBM
-
NCT01110603
Details
2016-05-05
Interventional
112 
Carboplatin Doxorubicin Liposomal doxor… Niraparib Paclitaxel
Neoplasms Cancer: Solid T…
-
-
NCT00603577
Details
2016-05-05
Interventional
3102 
Xaliproden
Colorectal Neop…
development of product discontinued
-
NCT02507323
Details
2016-05-04
Interventional
20 
Prasugrel Hydro… Ticagrelor
Cardiovascular … Cardiovascular …
collaborator withdrew the study
-
NCT01562951
Details
2016-05-04
Interventional
315 
Adalimumab
Crohn Disease Inflammation Mucositis Crohn's Disease Mucosal Inflamm…
Not enough patient population according to selection criteria to complete the study
-
NCT01558011
Details
2016-05-04
Interventional
251 
Capecitabine Docetaxel Oxaliplatin
Adenocarcinoma Gastric Adenoca…
The budget issues.
-
NCT00971126
Details
2016-05-04
Interventional
1/23 
Sorafenib Thalidomide
Carcinoma Carcinoma, Hepa… Hepatocellular …
Two patients in the first dose level be counted as reaching DLT. DSMB recommend terminated early this trial.
-
NCT02463110
Details
2016-05-03
Interventional
42 
Sertraline
Coronary Artery… Coronary Diseas… Depression Depressive Diso… Myocardial Infa… Myocardial Isch… Necrosis
Investigator's decision
-
NCT01587508
Details
2016-05-03
Interventional
30 
Amitriptyline Cyclobenzaprine Meloxicam
Low Back Pain Acute Lumbago
The comparator product was withdrawn from the brazilian market not being possible to conduct the design regarding initially planned.
-
NCT01567904
2011-005155-14
Details
2016-05-03
Interventional
22 
Semuloparin
Thrombosis Thrombosis Prop…
Decision from Sanofi to withdraw on a worldwide basis the Marketing Authorisation Applications for Semuloparin sodium in the adult indication
-
NCT00591357
Details
2016-05-03
Interventional
4-
Antidiarrheals Loperamide
Clostridium Inf… Colitis Diarrhea Antibiotic-Asso… Clostridium Dif…
Lack of personnel to complete trial
-
NCT02414555
Details
2016-05-02
Interventional
460 
Norepinephrine Phenylephrine Vasoconstrictor…
Critical Illnes…
Patient Safety
-
NCT02392676
Details
2016-05-02
Interventional
30 
Olaparib
Carcinoma, Ovar… Hypersensitivit… Ovarian Neoplas… Platinum Sensit…
Study is unlikely to be feasible given the evolving ovarian cancer landscape and alternative studies have the potential to meet future clinical demand.
-
NCT02144753
Details
2016-05-02
Interventional
2120 
Calcium polycar… Psyllium
Constipation Irritable Bowel… Constipation-pr…
Per DSMB, study fiber had given subjects more adverse events and made their IBS symptoms worse than the psyllium group.
-
NCT02338531
2014-004358-32
Details
2016-04-29
Interventional
20 
Nirogacestat
Breast Neoplasm… Triple Negative… Breast Cancer
Due to the discontinuation of the development of the Notch inhibitor PF-03084014-04
-
NCT01981707
2013-003058-25
Details
2016-04-28
Interventional
2/312 
Choline
Prostatic Neopl… Prostatic Neopl… Castration-resi…
enrollment default
-
NCT01697735
Details
2016-04-28
Interventional
424 
Atorvastatin Rosuvastatin Ca…
Dyslipidemias Hyperlipidemias
Because of lack of participants and funds
-
NCT02014649
Details
2016-04-22
Interventional
1/215 
Laninamivir Zanamivir
Influenza, Huma… Influenza
Study was terminated as per BARDA decision to terminate contract.
-
NCT01807156
Details
2016-04-22
Interventional
27 
Tivozanib
Carcinoma, Hepa… Liver Neoplasms Hepatocellular …
Primary endpoint not met
-