Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT05372887
Details
2023-12-11
Interventional
20 
Cyclobenzaprine
PTSD
The study was stopped due to business reasons.
-
NCT05201183
Details
2023-12-11
Interventional
1/20 
Fludarabine
Hematologic Neo… Leukemia Leukemia, Myelo… Leukemia, Myelo… Myelodysplastic… Precursor Cell … Acute Lymphocyt… Acute Myeloid L… Chronic Myeloid…
insufficient staff and updates in standard practice have made it difficult to recruit participants
-
NCT04497870
Details
2023-12-11
Interventional
10 
Menthol Peppermint oil
Abdominal Pain
This study was superseded by NCT03295747
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NCT04455815
2020-002110-41
Details
2023-12-11
Interventional
234 
Camostat Gabexate
COVID-19 Infections COVID-19 Infect…
Sponsor decision
-
NCT03964051
2017-003627-30
Details
2023-12-11
Interventional
47 
Omalizumab
Anaphylaxis Food Hypersensi… Food Allergy
Finished
-
NCT01050218
Details
2023-12-11
Interventional
3237 
Desvenlafaxine …
Diabetic Neurop… Peripheral Nerv… Diabetic Neurop…
Business reasons
-
NCT05193604
Details
2023-12-08
Interventional
129 
Gemcitabine Paclitaxel
Carcinoma Pancreatic Neop… Pancreatic Carc…
Terminated due to the adjustment of sponsor's development strategies and pipeline.
-
NCT04513067
Details
2023-12-08
Interventional
13 
Pembrolizumab
Neoplasms Advanced Solid …
Due to business decision
-
NCT04478266
2020-001824-33
Details
2023-12-08
Interventional
31068 
Goserelin Letrozole Palbociclib
Breast Neoplasm… Breast Cancer
The study was terminated based on the review by an independent data monitoring committee of the prespecified interim analysis of the Phase 3 AMEERA-5 efficacy data. No new safety signals were observed.
The study was terminated based on the review by an independent data monitoring committee of the prespecified interim analysis of the Phase 3 AMEERA-5 efficacy data.
NCT03954314
Details
2023-12-08
Interventional
3
[5 Refs]
3242 
Tranexamic Acid
Blood Loss, Sur… Hemorrhage Postoperative H… Seizures Bleeding Surgical Blood …
Upon the Data Safety Monitoring Board review of the interim analysis (75% of participants have finished their follow-up) on November 17, 2023, they made a recommendation to stop recruitment into the trial.
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NCT05653427
Details
2023-12-07
Interventional
218 
Amivantamab-vmj…
Carcinoma Carcinoma, Hepa…
N~15 subjects data analysis did not meet statistical consideration of ORR and study primary/secondary objectives were not met. Enrollment was terminated for futility
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NCT05487040
Details
2023-12-07
Interventional
115 
Nirmatrelvir Ritonavir
COVID-19
Decision to terminate study was due to slow enrolment and FDA input that available data may be enough for dosing recommendations for severe renal disease (subject to review by FDA).
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NCT03701763
2018-002918-12
Details
2023-12-07
Interventional
3245 
Apremilast
Psoriasis
PPSO-003 (20200056) is closing: - Last Subject Enrolled was 30-Dec-2021 - The Recruitment Status has to be updated to Terminated. LSLV was achieved 27-Mar-2023
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NCT05364099
Details
2023-12-06
Interventional
40 
Lidocaine Triamcinolone
Shoulder Pain Spinal Cord Inj… Chronic Shoulde…
Unable to feasibly complete study.
-
NCT03582033
Details
2023-12-06
Interventional
183 
Dexamethasone Pomalidomide
Multiple Myelom… Neoplasms, Plas…
Study closed due to portfolio prioritization
-
NCT02608268
2015-002354-12
Details
2023-12-06
Interventional
1/2252 
Decitabine Spartalizumab
Neoplasms Advanced Malign…
Business reasons
-
NCT04894994
Details
2023-12-05
Interventional
26 
Ipilimumab
Melanoma Advanced Melano…
Change in clinical landscape
The study was terminated early due to changes in the treatment landscape of melanoma that have occurred since the initiation of the study, leading to small numbers of subjects analyzed.
NCT02649673
Details
2023-12-05
Interventional
134 
Topotecan
Lung Neoplasms Small Cell Lung… Ovarian Cancer Small Cell Lung…
Clinical program was discontinued by Novartis
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NCT02642094
Details
2023-12-05
Interventional
258 
Sirolimus
Breast Neoplasm… Cancer of Breas…
The study was terminated early according to the protocol due to efficacy.
Our hypothesis was that a low dose and short term treatment with rapamycin in patients with early stage breast cancer would show significantly attenuation of mammary stem and progenitor cell activity and tumor progression biomarkers in a non-randomized study.
NCT01751425
Details
2023-12-05
Interventional
18 
Dasatinib Imatinib Mesyla… Janus Kinase In… Nilotinib
Leukemia Leukemia, Myelo… Leukemia, Myelo… Neoplasm, Resid… Philadelphia Ch… Chronic Myeloge… Chronic Myeloge… Minimal Residua… Philadelphia Ch…
Per PI Request. 2) No additional benefit was noted with the addition of Ruxolitinib.
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