Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01120275
Details
2016-06-14
Interventional
236 
2,2-dimethyl-N-…
Hutchinson's Me… Lentigo Melanoma Acral Lentigino… Lentigo Maligna… Nodular Maligna… Recurrent Melan… Solar Radiation… Stage IV Melano… Superficial Spr…
Administratively complete.
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NCT01658527
2012-002122-67
Details
2016-06-10
Interventional
20 
Bicalutamide
Prostatic Neopl… Prostate Cancer
Pharmaceutical company has terminated orteronel (TAK-700) development for Prostate Cancer
-
NCT02791256
2005-000198-22
Details
2016-06-08
Interventional
323 
Peginterferon a… Ribavirin
Hepatitis Hepatitis A Hepatitis C Hepatitis C, Ch…
-
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NCT00478972
Details
2016-06-08
Interventional
3321 
Rimonabant
Diabetes Mellit… Diabetes Mellit… Obesity
Company decision taken in light of demands by certain national health authorities
-
NCT00574275
2007-003476-19
Details
2016-06-07
Interventional
3
[1 Refs]
546 
Aflibercept Gemcitabine
Pancreatic Neop… Pancreatic Neop…
Data Monitoring Committee concluded after a planned interim analysis that aflibercept added to gemcitabine would be unable to demonstrate improved survival
As the study was terminated due to futility, some changes were made to the planned analyses, and the analyses for the following outcome measures were not performed: Objective Response Rate (ORR) Clinical Benefit
NCT02060955
Details
2016-06-06
Interventional
225 
Bevacizumab Irinotecan
Glioblastoma Glioblastoma Mu…
Substantial design modifications required.
-
NCT00478595
Details
2016-06-06
Interventional
3458 
Hypoglycemic Ag… Rimonabant
Diabetes Mellit… Diabetes Mellit… Obesity
Company decision taken in light of demands by certain national health authorities
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NCT01003678
Details
2016-06-03
Interventional
14 
Clofarabine
Myelodysplastic… Preleukemia Syndrome Myelodysplastic…
Drug provider withdrew support
-
NCT00313053
Details
2016-06-03
Interventional
14 
Vincristine
Leukemia Leukemia, Lymph… Precursor Cell … Acute Lymphoid … Leukemia, Lymph…
-
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NCT01549964
2011-001752-10
Details
2016-06-02
Interventional
3916 
Sitagliptin Pho…
Glycemic Contro…
Due to concerns about potential liver safety (See Detailed Description)
-
NCT02786732
Details
2016-06-01
Interventional
315 
Antibodies, Mon… Brodalumab Ustekinumab
Psoriasis
Sponsor
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NCT02349516
Details
2016-06-01
Interventional
20 
Ophthalmic Solu… Squalamine
Diabetic Retino… Macular Edema
Study cancelled as of 9/12/15. 0 subjects enrolled.
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NCT01829477
2013-000007-17
Details
2016-06-01
Interventional
333 
Glimepiride
Diabetes Mellit… Diabetes Mellit…
Due to potential concerns about liver safety (See Detailed Description)
-
NCT01743885
Details
2016-06-01
Interventional
355 
Acebutolol Propranolol
Hemangioma Hemangioma, Cap… Port-Wine Stain
-
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NCT01481116
2011-001731-24
Details
2016-06-01
Interventional
32454 
Glimepiride
Diabetes Mellit… Diabetes Mellit…
Due to potential concerns about liver safety (See Detailed Description)
-
NCT01407679
Details
2016-06-01
Interventional
27 
Alitretinoin
Lupus Erythemat… Lupus Erythemat…
-
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NCT02031965
Details
2016-05-30
Interventional
12 
Dexamethasone
Astrocytoma Glioblastoma Gliosarcoma Neoplasms, Neur… Oligodendroglio… Recurrence Recurrent Child… Recurrent Child… Recurrent Child… Recurrent Child… Recurrent Child… Recurrent Child… Recurrent Child…
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NCT02052635
Details
2016-05-27
Interventional
434 
Clopidogrel Ticagrelor
Acute Coronary … Syndrome Non-ST Elevatio…
Patient recruitment challenges, low enrolment, and a forecasted inability to complete the study in an acceptable timeframe
The target sample size for this study was 100 patients. But due to recruitment challenges and low enrolment,the study was terminated early with only 13 pateints randomized. No formal statistical analyses were performed.
NCT01721330
Details
2016-05-27
Interventional
43 
Naltrexone
Attention Defic… Hyperkinesis ADHD Attention Defic…
Competing studies
The study was terminated prior to completion due to competing studies. Therefore, only one subject in each group was analyzed.
NCT00585442
Details
2016-05-27
Interventional
112 
Calcitriol Vitamin D
Vitamin D Defic… Hypertension
Lack of quality data
-