Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01381640
Details
2016-07-06
Interventional
10 
Acetaminophen
Healthy Subject…
Study was cancelled prior to enrolling any subjects.
-
NCT00951444
Details
2016-07-06
Interventional
20 
Carboplatin Gemcitabine
Lung Neoplasms Lung Cancer
The study was not activated.
-
NCT00571740
Details
2016-07-06
Interventional
20 
Bevacizumab Calcium Cetuximab Fluorouracil Leucovorin Levoleucovorin Oxaliplatin
Colorectal Neop… Colorectal Canc…
The study was not activated
-
NCT00268437
Details
2016-07-06
Interventional
2
[2 Refs]
27 
Carboplatin Pemetrexed
Esophageal Neop… Esophageal Canc…
Trial closed early because, during an interim analysis, the primary endpoint fell short.
-
NCT01798485
2012-004349-34
Details
2016-07-01
Interventional
3696 
Docetaxel
Adenocarcinoma Adenocarcinoma … Carcinoma, Non-… Lung Neoplasms Non-Small-Cell … Non-small Cell … Non-small Cell … Non-small Cell …
The study was stopped after the first Interim Analysis due to futility.
-
NCT01003938
Details
2016-06-30
Interventional
26 
Erlotinib Hydro… Topotecan
Carcinoma, Ovar… Ovarian Neoplas… Ovarian Cancer
due to administrative issue and financial sponsor decision to suspend ovarian cancer studies
-
NCT01473303
Details
2016-06-28
Interventional
1/20 
Calcium Fluorouracil Irinotecan Leucovorin Levoleucovorin Oxaliplatin
Pancreatic Neop… Pancreatic Canc…
CALGB 81003 closed about a week after it was activated because of withdrawal of support. No patients were registered on this study.
-
NCT01092832
2009-012848-16
Details
2016-06-23
Interventional
323 
Voriconazole
Candidiasis
This protocol terminated prematurely on July 8, 2013 due to slow enrollment, not because of any safety issues or concerns.
The study was prematurely terminated due to slow enrollment. The study was not terminated due to any safety issues or concerns. Interpretation of the data are limited due to the small sample size and descriptive design.
NCT01808950
Details
2016-06-22
Interventional
1/24 
Resiquimod
Carcinoma Carcinoma, Basa… Nodular Basal C…
safety issues
-
NCT00532311
Details
2016-06-22
Interventional
3411 
Atorvastatin Dihydromevinoli… Hydroxymethylgl… L 647318 Lovastatin Pravastatin Rosuvastatin Ca… Simvastatin
Hypercholestero…
Overall profile of the compound does not offer significant clinical advantage to patients over currently available lipid lowering agents
-
NCT02786979
Details
2016-06-21
Interventional
4190 
Aspirin Beraprost
Arteriosclerosi… Diabetes Mellit… Diabetes Mellit… Type 2 Diabetes…
Upon interim analysis, sponsor's decision due to absence of demonstration of efficacy.
-
NCT01048086
Details
2016-06-21
Interventional
20 
Isotretinoin Tretinoin
Neuroblastoma Neuroendocrine … Neuroendocrine …
No patients were enrolled because the company that pledged the drug does not yet have it available.
-
NCT02177734
2014-000796-27
Details
2016-06-20
Interventional
10 
Vaccines
Influenza, Huma… Influenza
The study was cancelled for scientifically legitimate reasons not related to safety or efficacy of the vaccine.
-
NCT01428154
Details
2016-06-17
Interventional
10 
Darbepoetin alf…
Anemia Kidney Diseases Renal Insuffici… Chronic Kidney …
Difficulty in recruitment. PDCO in the Day 30 summary report agrred to remove the PK study in children <1 year of age.
-
NCT01373918
Details
2016-06-16
Interventional
441 
Soybean oil, ph…
Cholestasis Digestive Syste… Gastrointestina…
The study was terminated due to slow enrollment.
Early termination leading to small number of subjects analyzed.
NCT00831649
Details
2016-06-16
Interventional
2-
Natalizumab
Arthritis Arthritis, Rheu… Rheumatoid Arth…
The biological effect seen with natalizumab was not sufficient to warrant further development in RA.
-
NCT00801125
Details
2016-06-16
Interventional
40 
Natalizumab
Crohn Disease Crohn's Disease
Study sponsor decided to withdraw the current study prior to enrollment of first participant.
-
NCT00751296
Details
2016-06-16
Interventional
227 
Lenalidomide
Leukemia Leukemia, Lymph… Leukemia, Lymph… Chronic Lymphoc…
Seven years of follow-up & final analysis done in Dec 2012.
Original study protocol used a starting lenalidomide dose of 10mg OD for 21days of a 28-day cycle, escalating weekly by 5mg to a target of 25mg daily. Toxicities reported with the first two enrolled patients lead to the current protocol amendment.
NCT02378740
Details
2016-06-15
Interventional
40 
Ketamine
Anesthesia Pain Surgery
PI has left the University
-
NCT02087176
Details
2016-06-14
Interventional
248 
Adavosertib Antimitotic Age…
Carcinoma, Non-… Lung Neoplasms Previously Trea…
The study was terminated early by the sponsor.
The sponsor terminated the study early. The study was closed on May 12, 2015. Part B of the study was not done.