Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01408849
Details
2016-07-26
Interventional
24 
Omeprazole
Dyspepsia
Lack of adherence and huge loss of follow up.
-
NCT01078974
Details
2016-07-25
Interventional
17 
Dexamethasone Pomalidomide Rituximab
Waldenstrom Mac… Waldenstrom's M…
Safety concerns (IgM Flare)
Pomalidomide and rituximab could have a synergistic effect on serum IgM levels and produce an IgM flare. The highest dose of pomalidomide in this trial was 1mg. The study was permanently closed to accrual given the safety concerns with the IgM flare.
NCT00417248
Details
2016-07-25
Interventional
1/28 
Etoposide Sorafenib
Carcinoma, Non-… Lung Neoplasms Non-Small Cell …
Negative sorafenib results from ESCAPE trial and safety concerns of regimen
-
NCT00102947
Details
2016-07-25
Interventional
4-
Daptomycin
Communicable Di… Infections Skin Diseases, … Soft Tissue Inf…
-
-
NCT02731846
Details
2016-07-22
Interventional
30 
Albuterol Fluticasone Xhance
Lung Diseases Lung Diseases, … Pulmonary Disea…
It has been determined on June 10th that the 205165 study will not progress. This decision has been made prior to study start, no patients were screened.
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NCT00724841
Details
2016-07-22
Interventional
1/21 
Obatoclax Temozolomide
Melanoma Metastatic Mela…
Study terminated prematurely due to financial contraints.
-
NCT02675413
Details
2016-07-20
Interventional
40 
Dimethyl Fumara…
Multiple Sclero… Multiple Sclero… Sclerosis
Principal Investigator decided to withdraw.
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NCT01701063
Details
2016-07-20
Interventional
1/242 
Peginterferon a… Ribavirin
Hepatitis Hepatitis A Hepatitis C
-
Study was terminated early because it was determined that telaprevir/Peg-IFN/RBV regimen did not present a meaningful therapeutic treatment over existing interferon-free regimens and was unlikely to be used for participants aged 3 to 17 years.
NCT01390441
Details
2016-07-20
Interventional
1100 
Acetaminophen Loratadine Methotrexate Methylprednisol… Rituximab
Arthritis Arthritis, Rheu… Rheumatoid Arth…
The study was terminated early by the Sponsor for business reasons.
-
NCT00627835
Details
2016-07-20
Interventional
10 
Cisplatin Sorafenib
Carcinoma Carcinoma, Squa… Squamous Cell C… Locally Advance…
Site decided not to open this study
-
NCT02221232
Details
2016-07-18
Interventional
264 
Chlorhexidine Chlorhexidine g… Ethanol
Surgical Wound … Surgical Site I…
To assess product performance (test and reference products), move into further testing.
-
NCT01723501
Details
2016-07-18
Interventional
2/30 
Chlorhexidine
Neonatal Sepsis Sepsis Neonatal Mortal…
The study was not started and prematurely closed.
-
NCT00297232
Details
2016-07-15
Interventional
3
[3 Refs]
1094 
Natalizumab
Multiple Sclero… Multiple Sclero… Sclerosis Relapsing-Remit…
-
Sponsor decided to terminate the study prior to all subjects reaching Week 480 as the primary objective was deemed to have been met and only approximately 45% of the original STRATA population remained in the study at the time of study termination.
NCT01577524
Details
2016-07-14
Interventional
258 
Povidone Povidone-Iodine
Surgical Wound … Surgical Site I…
We had very low recruitment rates that would have resulted in several years being added to the study to achieve an appropriate sample size.
-
NCT02599701
Details
2016-07-13
Interventional
48 
Gabapentin
Sleep
Gabapentin increased hypopnea-apnea index in the first 8 recruited subjects.
-
NCT01226745
2010-018705-11
Details
2016-07-12
Interventional
2
[1 Refs]
340 
Ceralifimod
Multiple Sclero… Multiple Sclero… Sclerosis
Merck has decided to not pursue phase 3 development of ceralifimod (ONO-4641). The decision was not related to any safety and efficacy findings
Company has decided to not pursue phase 3 development of ceralifimod (ONO-4641). The decision was not related to any safety and efficacy findings.
NCT00053339
Details
2016-07-12
Interventional
30 
Tamoxifen Trastuzumab
Breast Neoplasm… Recurrent Breas… Stage IV Breast…
The study was not activated.
-
NCT02703233
Details
2016-07-11
Interventional
40 
Nitrous Oxide
Lacerations Abscess
Feasibility
-
NCT02347033
Details
2016-07-11
Interventional
45 
Sertraline
Anxiety Disorde… Generalised Anx…
Difficulties with recruitment during the internal pilot phase
-
NCT02152059
Details
2016-07-06
Interventional
20 
Nintedanib
Hypersensitivit… Lung Neoplasms Small Cell Lung… Platinum-sensit… Small Cell Lung…
contract issues
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